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• W2059702937 endingPage "3238" @default.
• W2059702937 startingPage "3223" @default.
• W2059702937 abstract "Thermal ablation by high intensity focused ultrasound (HIFU) has a great potential for the non-invasive treatment of solid tumours. Due to the high pressure amplitudes involved, nonlinear acoustic effects must be understood and the relevant medium property is the parameter of nonlinearity B/A. Here, B/A was measured in ex vivo bovine liver, over a heating/cooling cycle replicating temperatures reached during HIFU ablation, adapting a finite amplitude insertion technique, which also allowed for measurement of sound-speed and attenuation. The method measures the nonlinear progression of a plane wave through liver and B/A was chosen so that numerical simulations matched the measured waveforms. To create plane-wave conditions, sinusoidal bursts were transmitted by a 100 mm diameter 1.125 MHz unfocused transducer and measured using a 15 mm diameter 2.25 MHz broadband transducer in the near field. Attenuation and sound-speed were calculated using a reflected pulse from the smaller transducer using the larger transducer as the reflecting interface. Results showed that attenuation initially decreased with heating then increased after denaturation, the sound-speed initially increased with temperature and then decreased, and B/A showed an increase with temperature but no significant post-heating change. The B/A data disagree with other reports that show a significant change and we suggest that any nonlinear enhancement in the received ultrasound signal post-treatment is likely due to acoustic cavitation rather than changes in tissue nonlinearity." @default.
• W2059702937 created "2016-06-24" @default.
• W2059702937 creator A5042082739 @default.
• W2059702937 creator A5057146811 @default.
• W2059702937 creator A5067420995 @default.
• W2059702937 date "2014-05-27" @default.
• W2059702937 modified "2023-09-26" @default.
• W2059702937 title "Nonlinear acoustic properties of <i>ex vivo</i> bovine liver and the effects of temperature and denaturation" @default.
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• W2059702937 doi "https://doi.org/10.1088/0031-9155/59/12/3223" @default.
• W2059702937 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24862475" @default.
• W2059702937 hasPublicationYear "2014" @default.
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