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• W2059706603 abstract "A central question in the study of cell proliferation is, what controls cell-cycle transitions? Although the accumulation of mitotic cyclins drives the transition from the G 2 phase to the M phase in embryonic cells, the trigger for mitotic entry in somatic cells remains unknown. We report that the synergistic action of Bora and the kinase Aurora A (Aur-A) controls the G 2 -M transition. Bora accumulates in the G 2 phase and promotes Aur-A–mediated activation of Polo-like kinase 1 (Plk1), leading to the activation of cyclin-dependent kinase 1 and mitotic entry. Mechanistically, Bora interacts with Plk1 and controls the accessibility of its activation loop for phosphorylation and activation by Aur-A. Thus, Bora and Aur-A control mitotic entry, which provides a mechanism for one of the most important yet ill-defined events in the cell cycle." @default.
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• W2059706603 date "2008-06-20" @default.
• W2059706603 modified "2023-10-18" @default.
• W2059706603 title "Bora and the Kinase Aurora A Cooperatively Activate the Kinase Plk1 and Control Mitotic Entry" @default.
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• W2059706603 doi "https://doi.org/10.1126/science.1157425" @default.
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