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- W2059711760 abstract "A series of sympathominetic agents and related substances were tested for their effect upon the EEG and blood pressure of the unanesthetized cat with mid-reticular coagulation. Adrenaline, noradrenaline, and phenylephrine all produced prompt, short-lasting and reproducible EEG activation and rise in blood pressure, but showed certain quantitative differences. Methamphetamine produced a feeble direct effect upon the EEG and blood pressure, and both responses showed tachyphylaxis. Both methamphetamine and cocaine were able to lower the threshold to adrenaline EEG activation ten-fold or more, and in large enough cumulative doses produced a sustained EEG activation which was abolished by further destruction of the mesencephalic tegmentum. Serotonin produced alternate phases of EEG activation and deactivation dissimilar in pattern to that produced by the sympathomimetic agents. It is postulated that the central nervous system stimulating properties of methamphetamine and cocaine observed clinically are due to their sensitizing effect upon adrenergic component of the reticular activating system." @default.
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- W2059711760 title "The effect of phenylephrine, methamphetamine, cocaine, and serotonin upon the adrenaline sensitive component of the reticular activating system" @default.
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- W2059711760 doi "https://doi.org/10.1016/0013-4694(57)90030-5" @default.
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