Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059712176> ?p ?o ?g. }
- W2059712176 endingPage "100" @default.
- W2059712176 startingPage "85" @default.
- W2059712176 abstract "In long-lived C. elegans insulin/IGF-1 pathway mutants, the life-extending FOXO transcription factor DAF-16 is present throughout the animal, but we find that its activity in a single tissue can delay the aging of other tissues and extend the animal's life span. To better understand the topography of DAF-16 action among the tissues, we analyzed a collection of DAF-16-regulated genes. DAF-16 regulated most of these genes in a cell-autonomous fashion, often using tissue-specific GATA factors to direct their expression to specific tissues. DAF-16 could also act cell nonautonomously to influence gene expression. DAF-16 affected gene expression in other cells, at least in part, via the lipid-gene regulator MDT-15. DAF-16, and probably MDT-15, could act cell nonautonomously in the endoderm to ameliorate the paralysis caused by expressing Alzheimer's Aβ protein in muscles. These findings suggest that MDT-15-dependent intercellular signals, possibly lipid signals, can help to coordinate tissue physiology, enhance proteostasis, and extend life in response to DAF-16/FOXO activity." @default.
- W2059712176 created "2016-06-24" @default.
- W2059712176 creator A5041845656 @default.
- W2059712176 creator A5053475144 @default.
- W2059712176 creator A5071949326 @default.
- W2059712176 creator A5084711074 @default.
- W2059712176 date "2013-01-01" @default.
- W2059712176 modified "2023-10-10" @default.
- W2059712176 title "Direct and Indirect Gene Regulation by a Life-Extending FOXO Protein in C. elegans: Roles for GATA Factors and Lipid Gene Regulators" @default.
- W2059712176 cites W1486595217 @default.
- W2059712176 cites W1515211957 @default.
- W2059712176 cites W1524354116 @default.
- W2059712176 cites W1561509846 @default.
- W2059712176 cites W1631908837 @default.
- W2059712176 cites W1963574778 @default.
- W2059712176 cites W1964701096 @default.
- W2059712176 cites W1967066869 @default.
- W2059712176 cites W1975183137 @default.
- W2059712176 cites W1975595547 @default.
- W2059712176 cites W1976050844 @default.
- W2059712176 cites W1976078209 @default.
- W2059712176 cites W1982376676 @default.
- W2059712176 cites W1990185604 @default.
- W2059712176 cites W1991080848 @default.
- W2059712176 cites W1993978835 @default.
- W2059712176 cites W2005036104 @default.
- W2059712176 cites W2013388821 @default.
- W2059712176 cites W2018359498 @default.
- W2059712176 cites W2029530650 @default.
- W2059712176 cites W2030588276 @default.
- W2059712176 cites W2032306298 @default.
- W2059712176 cites W2034734284 @default.
- W2059712176 cites W2036931975 @default.
- W2059712176 cites W2043426556 @default.
- W2059712176 cites W2043829280 @default.
- W2059712176 cites W2046623154 @default.
- W2059712176 cites W2046989794 @default.
- W2059712176 cites W2055708395 @default.
- W2059712176 cites W2055893161 @default.
- W2059712176 cites W2056388945 @default.
- W2059712176 cites W2058484936 @default.
- W2059712176 cites W2062629127 @default.
- W2059712176 cites W2066660409 @default.
- W2059712176 cites W2066670143 @default.
- W2059712176 cites W2069988949 @default.
- W2059712176 cites W2070586322 @default.
- W2059712176 cites W2078654865 @default.
- W2059712176 cites W2079106483 @default.
- W2059712176 cites W2084904550 @default.
- W2059712176 cites W2084986953 @default.
- W2059712176 cites W2085793595 @default.
- W2059712176 cites W2087527859 @default.
- W2059712176 cites W2088231256 @default.
- W2059712176 cites W2091073857 @default.
- W2059712176 cites W2091613063 @default.
- W2059712176 cites W2098350013 @default.
- W2059712176 cites W2099008186 @default.
- W2059712176 cites W2109502717 @default.
- W2059712176 cites W2121263384 @default.
- W2059712176 cites W2121867223 @default.
- W2059712176 cites W2136493937 @default.
- W2059712176 cites W2141244689 @default.
- W2059712176 cites W2148581106 @default.
- W2059712176 cites W2150277522 @default.
- W2059712176 cites W2151034892 @default.
- W2059712176 cites W2153054542 @default.
- W2059712176 cites W2155265427 @default.
- W2059712176 cites W2157617952 @default.
- W2059712176 cites W2161758212 @default.
- W2059712176 cites W2166146113 @default.
- W2059712176 cites W2166889104 @default.
- W2059712176 cites W2168922008 @default.
- W2059712176 doi "https://doi.org/10.1016/j.cmet.2012.12.013" @default.
- W2059712176 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3969420" @default.
- W2059712176 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23312285" @default.
- W2059712176 hasPublicationYear "2013" @default.
- W2059712176 type Work @default.
- W2059712176 sameAs 2059712176 @default.
- W2059712176 citedByCount "160" @default.
- W2059712176 countsByYear W20597121762013 @default.
- W2059712176 countsByYear W20597121762014 @default.
- W2059712176 countsByYear W20597121762015 @default.
- W2059712176 countsByYear W20597121762016 @default.
- W2059712176 countsByYear W20597121762017 @default.
- W2059712176 countsByYear W20597121762018 @default.
- W2059712176 countsByYear W20597121762019 @default.
- W2059712176 countsByYear W20597121762020 @default.
- W2059712176 countsByYear W20597121762021 @default.
- W2059712176 countsByYear W20597121762022 @default.
- W2059712176 countsByYear W20597121762023 @default.
- W2059712176 crossrefType "journal-article" @default.
- W2059712176 hasAuthorship W2059712176A5041845656 @default.
- W2059712176 hasAuthorship W2059712176A5053475144 @default.
- W2059712176 hasAuthorship W2059712176A5071949326 @default.
- W2059712176 hasAuthorship W2059712176A5084711074 @default.
- W2059712176 hasBestOaLocation W20597121761 @default.
- W2059712176 hasConcept C104317684 @default.
- W2059712176 hasConcept C150194340 @default.