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- W2059716804 endingPage "1147" @default.
- W2059716804 startingPage "1135" @default.
- W2059716804 abstract "Malignant glioma is among of the most devastating, and least curable, types of cancer. Since the re-emergence of the cancer stem cell hypothesis, much progress has been made towards elucidating the cellular origin of these tumors. The hypothesis that tumors are hierarchically organized, with a cancer stem cell at the top that shares defining features with somatic stem cells and provides therapeutic refractoriness properties, has put adult stem cells into the limelight as prime suspect for malignant glioma. Much confusion still exists, though, as to the particular cell type and processes that lead to oncogenic transformation. In this review, we will discuss recent developments and novel hypotheses regarding the origin of malignant gliomas, especially glioblastoma. In particular, we argue that glioblastoma is the result of different pathways originating in multiple sources that all ultimately converge in the same disease. Further attention is devoted to potential scenarios leading to transformation of different stem/progenitor cell types of the brain, and the probability and relevance of these scenarios for malignant tumorigenesis." @default.
- W2059716804 created "2016-06-24" @default.
- W2059716804 creator A5003141905 @default.
- W2059716804 creator A5025557106 @default.
- W2059716804 creator A5029771729 @default.
- W2059716804 creator A5069602380 @default.
- W2059716804 creator A5082335176 @default.
- W2059716804 date "2011-02-23" @default.
- W2059716804 modified "2023-10-07" @default.
- W2059716804 title "The origins of glioma: E Pluribus Unum?" @default.
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