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• W2059722331 abstract "GTF2I and GTF2IRD1 encode members of the TFII-I transcription factor family and are prime candidates in the Williams syndrome, a complex neurodevelopmental disorder. Our previous expression microarray studies implicated TFII-I proteins in the regulation of a number of genes critical in various aspects of cell physiology. Here, we combined bioinformatics and microarray results to identify TFII-I downstream targets in the vertebrate genome. These results were validated by chromatin immunoprecipitation and siRNA analysis. The collected evidence revealed the complexity of TFII-I-mediated processes that involve distinct regulatory networks. Altogether, these results lead to a better understanding of specific molecular events, some of which may be responsible for the Williams syndrome phenotype." @default.
• W2059722331 created "2016-06-24" @default.
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• W2059722331 date "2008-07-01" @default.
• W2059722331 modified "2023-09-25" @default.
• W2059722331 title "Identification of the TFII-I family target genes in the vertebrate genome" @default.
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• W2059722331 doi "https://doi.org/10.1073/pnas.0803051105" @default.
• W2059722331 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2449355" @default.
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