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• W2059732321 endingPage "1349" @default.
• W2059732321 startingPage "1340" @default.
• W2059732321 abstract "Previous studies have suggested that target-derived nerve growth factor (NGF) is essential for the survival of cholinergic basal forebrain neurons. Thus, axotomy of septohippocampal neurons in adult rats resulting in the withdrawal of target-derived NGF caused a dramatic loss of choline acetyltransferase (ChAT)-immunoreactive neurons in the medial septum-diagonal band complex. We have recently shown that this loss of immunolabelled neurons does not indicate cell death, since many septohippocampal cholinergic neurons recover their immunoreactivity for ChAT after a long survival time despite disconnection from target-derived neurotrophins. One possibility would be that these surviving ChAT-immunoreactive neurons have gained access to other, probably local, NGF sources. Here we provide evidence that the recovery of ChAT immunoreactivity after axotomy is not accompanied by a similar recovery of NGF receptor expression in these neurons. In situ hybridization for p75NTR mRNA and trkA mRNA 6 months after bilateral fimbria-fornix transection revealed a substantial loss of labelled cells. In addition, there was a persisting loss of p75NTR-immunoreactive and NGF-immunoreactive medial septal neurons. Cholinergic neurons in controls did not express NGF mRNA, but were heavily immunostained for NGF protein due to receptor-mediated uptake. These data suggest that at least some cholinergic septohippocampal neurons re-express ChAT either independently of NGF or with a reduced need for NGF." @default.
• W2059732321 created "2016-06-24" @default.
• W2059732321 creator A5002693055 @default.
• W2059732321 creator A5026520425 @default.
• W2059732321 creator A5088924017 @default.
• W2059732321 date "1997-07-01" @default.
• W2059732321 modified "2023-09-27" @default.
• W2059732321 title "Recovery of ChAT lmmunoreactivity in Axotomized Rat Cholinergic Septal Neurons Despite Reduced NGF Receptor Expression" @default.
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• W2059732321 doi "https://doi.org/10.1111/j.1460-9568.1997.tb01488.x" @default.
• W2059732321 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9240391" @default.
• W2059732321 hasPublicationYear "1997" @default.
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