FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059750112> ?p ?o ?g. }

• W2059750112 endingPage "231" @default.
• W2059750112 startingPage "221" @default.
• W2059750112 abstract "With the completion of the genome of Mycobacterium tuberculosis comes the promise of a new generation of potent drugs to combat the emerging epidemic of multiply drug-resistant isolates. Translating this genomic information into realistic assays, valid targets, and preclinical drug candidates represents the next great hope in tuberculosis control. We propose a paradigm for exploiting the genome to inform the development of novel antituberculars, utilizing the techniques of differential gene expression as monitored by DNA microarrays coupled with the emerging discipline of combinatorial chemistry. A comparison of currently used antituberculars with the properties of other pharmaceuticals suggests that such compounds will have a defined range of physiochemical properties. In general, we can expect the next generation of antituberculars to be small, relatively hydrophilic molecules that bind tightly to specific cellular targets. Many current antimycobacterials require some form of cellular activation (e.g. the activation of isoniazid by a catalase-peroxidase). Activation corresponds to the oxidative, reductive, or hydrolytic unmasking of reactive groups, which occurs with many current antimycobacterial prodrugs. Understanding the mechanisms involved in activation of current antimycobacterial therapeutics also may facilitate the development of alternative activation strategies or of analogs that require no such processes." @default.
• W2059750112 created "2016-06-24" @default.
• W2059750112 creator A5008410969 @default.
• W2059750112 creator A5018322506 @default.
• W2059750112 creator A5025665480 @default.
• W2059750112 creator A5073566531 @default.
• W2059750112 date "2000-02-01" @default.
• W2059750112 modified "2023-09-29" @default.
• W2059750112 title "Use of genomics and combinatorial chemistry in the development of new antimycobacterial drugs" @default.
• W2059750112 cites W1670951778 @default.
• W2059750112 cites W1963975384 @default.
• W2059750112 cites W1979917155 @default.
• W2059750112 cites W1981788436 @default.
• W2059750112 cites W1985064413 @default.
• W2059750112 cites W1986538901 @default.
• W2059750112 cites W1987475267 @default.
• W2059750112 cites W1994149926 @default.
• W2059750112 cites W1995016187 @default.
• W2059750112 cites W1998563168 @default.
• W2059750112 cites W2010595835 @default.
• W2059750112 cites W2011605425 @default.
• W2059750112 cites W2015922674 @default.
• W2059750112 cites W2027600997 @default.
• W2059750112 cites W2032080946 @default.
• W2059750112 cites W2036221447 @default.
• W2059750112 cites W2046564413 @default.
• W2059750112 cites W2048414795 @default.
• W2059750112 cites W2051650016 @default.
• W2059750112 cites W2052907531 @default.
• W2059750112 cites W2054080822 @default.
• W2059750112 cites W2061266515 @default.
• W2059750112 cites W2065130119 @default.
• W2059750112 cites W2067345781 @default.
• W2059750112 cites W2068605439 @default.
• W2059750112 cites W2069488321 @default.
• W2059750112 cites W2070087864 @default.
• W2059750112 cites W2071192895 @default.
• W2059750112 cites W2075000963 @default.
• W2059750112 cites W2075165521 @default.
• W2059750112 cites W2089109815 @default.
• W2059750112 cites W2094883982 @default.
• W2059750112 cites W2098335911 @default.
• W2059750112 cites W2099369211 @default.
• W2059750112 cites W2102014060 @default.
• W2059750112 cites W2109729152 @default.
• W2059750112 cites W2110078566 @default.
• W2059750112 cites W2149808870 @default.
• W2059750112 cites W2158023121 @default.
• W2059750112 cites W2164429494 @default.
• W2059750112 cites W2166215411 @default.
• W2059750112 cites W2167158113 @default.
• W2059750112 cites W2315232969 @default.
• W2059750112 cites W2317468541 @default.
• W2059750112 cites W2321042246 @default.
• W2059750112 cites W2343660944 @default.
• W2059750112 cites W2950609391 @default.
• W2059750112 cites W3187545835 @default.
• W2059750112 cites W4242754049 @default.
• W2059750112 cites W4244089516 @default.
• W2059750112 cites W4248107770 @default.
• W2059750112 doi "https://doi.org/10.1016/s0006-2952(99)00253-1" @default.
• W2059750112 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10609550" @default.
• W2059750112 hasPublicationYear "2000" @default.
• W2059750112 type Work @default.
• W2059750112 sameAs 2059750112 @default.
• W2059750112 citedByCount "126" @default.
• W2059750112 countsByYear W20597501122012 @default.
• W2059750112 countsByYear W20597501122013 @default.
• W2059750112 countsByYear W20597501122014 @default.
• W2059750112 countsByYear W20597501122015 @default.
• W2059750112 countsByYear W20597501122016 @default.
• W2059750112 countsByYear W20597501122017 @default.
• W2059750112 countsByYear W20597501122018 @default.
• W2059750112 countsByYear W20597501122019 @default.
• W2059750112 countsByYear W20597501122020 @default.
• W2059750112 countsByYear W20597501122022 @default.
• W2059750112 countsByYear W20597501122023 @default.
• W2059750112 crossrefType "journal-article" @default.
• W2059750112 hasAuthorship W2059750112A5008410969 @default.
• W2059750112 hasAuthorship W2059750112A5018322506 @default.
• W2059750112 hasAuthorship W2059750112A5025665480 @default.
• W2059750112 hasAuthorship W2059750112A5073566531 @default.
• W2059750112 hasConcept C104317684 @default.
• W2059750112 hasConcept C108215921 @default.
• W2059750112 hasConcept C141231307 @default.
• W2059750112 hasConcept C142724271 @default.
• W2059750112 hasConcept C150194340 @default.
• W2059750112 hasConcept C161078062 @default.
• W2059750112 hasConcept C161624437 @default.
• W2059750112 hasConcept C185592680 @default.
• W2059750112 hasConcept C189206191 @default.
• W2059750112 hasConcept C21951064 @default.
• W2059750112 hasConcept C2777975735 @default.
• W2059750112 hasConcept C2779685592 @default.
• W2059750112 hasConcept C2780035454 @default.
• W2059750112 hasConcept C2781069245 @default.
• W2059750112 hasConcept C55493867 @default.
• W2059750112 hasConcept C64903051 @default.

• next