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- W2059755977 endingPage "3490" @default.
- W2059755977 startingPage "3483" @default.
- W2059755977 abstract "The loss of a coding nucleobase from the structure of DNA is a common event that generates an abasic (Ap) site (1). Ap sites exist as an equilibrating mixture of a cyclic hemiacetal and a ring-opened aldehyde. Aldehydes are electrophilic functional groups that can form covalent adducts with nucleophilic sites in DNA. Thus, Ap sites present a potentially reactive aldehyde as part of the internal structure of DNA. Here we report evidence that the aldehyde group of Ap sites in duplex DNA can form a covalent adduct with the N(6)-amino group of adenine residues on the opposing strand. The resulting interstrand DNA-DNA cross-link occurs at 5'-ApT/5'-AA sequences in remarkably high yields (15-70%) under physiologically relevant conditions. This naturally occurring DNA-templated reaction has the potential to generate cross-links in the genetic material of living cells." @default.
- W2059755977 created "2016-06-24" @default.
- W2059755977 creator A5003013260 @default.
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- W2059755977 creator A5019900379 @default.
- W2059755977 creator A5025279909 @default.
- W2059755977 creator A5079033224 @default.
- W2059755977 date "2014-02-20" @default.
- W2059755977 modified "2023-10-18" @default.
- W2059755977 title "Interstrand DNA–DNA Cross-Link Formation Between Adenine Residues and Abasic Sites in Duplex DNA" @default.
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- W2059755977 doi "https://doi.org/10.1021/ja410969x" @default.
- W2059755977 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3954461" @default.
- W2059755977 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24506784" @default.
- W2059755977 hasPublicationYear "2014" @default.
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