Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059760930> ?p ?o ?g. }
- W2059760930 endingPage "65" @default.
- W2059760930 startingPage "43" @default.
- W2059760930 abstract "Pulmonary arterial hypertension (PAH) is a rare disease in infants and children that is associated with significant morbidity and mortality. The disease is characterized by progressive pulmonary vascular functional and structural changes resulting in increased pulmonary vascular resistance and eventual right heart failure and death. In the majority of pediatric patients, PAH is idiopathic or associated with congenital heart disease and rarely is associated with other conditions such as connective tissue or thromboembolic disease. Although treatment of the underlying disease and reversal of advanced structural changes has not yet been achieved with current therapy, quality of life and survival have been improved significantly. Targeted pulmonary vasodilator therapies, including endothelin receptor antagonists, prostacyclin analogs, and phosphodiesterase type 5 inhibitors, have demonstrated hemodynamic and functional improvement in children. The management of pediatric PAH remains challenging, as treatment decisions continue to depend largely on results from evidence-based adult studies and the clinical experience of pediatric experts. This article reviews the current drug therapies and their use in the management of PAH in children." @default.
- W2059760930 created "2016-06-24" @default.
- W2059760930 creator A5014629531 @default.
- W2059760930 creator A5018055895 @default.
- W2059760930 date "2013-10-10" @default.
- W2059760930 modified "2023-10-14" @default.
- W2059760930 title "Drug Treatment of Pulmonary Hypertension in Children" @default.
- W2059760930 cites W13250750 @default.
- W2059760930 cites W1482672078 @default.
- W2059760930 cites W1536134154 @default.
- W2059760930 cites W1567116170 @default.
- W2059760930 cites W1575469977 @default.
- W2059760930 cites W1912876976 @default.
- W2059760930 cites W1950866905 @default.
- W2059760930 cites W1962876390 @default.
- W2059760930 cites W1964271363 @default.
- W2059760930 cites W1966222154 @default.
- W2059760930 cites W1967215100 @default.
- W2059760930 cites W1969722648 @default.
- W2059760930 cites W1971981339 @default.
- W2059760930 cites W1972156325 @default.
- W2059760930 cites W1973538347 @default.
- W2059760930 cites W1973984263 @default.
- W2059760930 cites W1974058266 @default.
- W2059760930 cites W1976294230 @default.
- W2059760930 cites W1977235125 @default.
- W2059760930 cites W1978777381 @default.
- W2059760930 cites W1979770196 @default.
- W2059760930 cites W1981051334 @default.
- W2059760930 cites W1981419253 @default.
- W2059760930 cites W1985982275 @default.
- W2059760930 cites W1986606267 @default.
- W2059760930 cites W1987618183 @default.
- W2059760930 cites W1990345361 @default.
- W2059760930 cites W1990794925 @default.
- W2059760930 cites W1991255552 @default.
- W2059760930 cites W1991439387 @default.
- W2059760930 cites W1993580604 @default.
- W2059760930 cites W1994219663 @default.
- W2059760930 cites W1996763820 @default.
- W2059760930 cites W1997713908 @default.
- W2059760930 cites W1999010833 @default.
- W2059760930 cites W2002756827 @default.
- W2059760930 cites W2003275918 @default.
- W2059760930 cites W2004478188 @default.
- W2059760930 cites W2005817462 @default.
- W2059760930 cites W2006623286 @default.
- W2059760930 cites W2007458222 @default.
- W2059760930 cites W2010511169 @default.
- W2059760930 cites W2011135087 @default.
- W2059760930 cites W2015292250 @default.
- W2059760930 cites W2018716226 @default.
- W2059760930 cites W2018975119 @default.
- W2059760930 cites W2019614667 @default.
- W2059760930 cites W2020973304 @default.
- W2059760930 cites W2023103539 @default.
- W2059760930 cites W2023607416 @default.
- W2059760930 cites W2025593289 @default.
- W2059760930 cites W2025885023 @default.
- W2059760930 cites W2026315635 @default.
- W2059760930 cites W2026939372 @default.
- W2059760930 cites W2029838701 @default.
- W2059760930 cites W2031197996 @default.
- W2059760930 cites W2033446584 @default.
- W2059760930 cites W2034685050 @default.
- W2059760930 cites W2035373759 @default.
- W2059760930 cites W2035384054 @default.
- W2059760930 cites W2039172749 @default.
- W2059760930 cites W2039518943 @default.
- W2059760930 cites W2040384567 @default.
- W2059760930 cites W2040768445 @default.
- W2059760930 cites W2041151644 @default.
- W2059760930 cites W2041782329 @default.
- W2059760930 cites W2041889301 @default.
- W2059760930 cites W2042073855 @default.
- W2059760930 cites W2042260765 @default.
- W2059760930 cites W2046102329 @default.
- W2059760930 cites W2047164601 @default.
- W2059760930 cites W2048635427 @default.
- W2059760930 cites W2049998346 @default.
- W2059760930 cites W2050656123 @default.
- W2059760930 cites W2051069436 @default.
- W2059760930 cites W2051549369 @default.
- W2059760930 cites W2054935021 @default.
- W2059760930 cites W2055488550 @default.
- W2059760930 cites W2055749314 @default.
- W2059760930 cites W2057857083 @default.
- W2059760930 cites W2060532020 @default.
- W2059760930 cites W2061742992 @default.
- W2059760930 cites W2062002285 @default.
- W2059760930 cites W2063646125 @default.
- W2059760930 cites W2063680880 @default.
- W2059760930 cites W2063788522 @default.
- W2059760930 cites W2064297934 @default.
- W2059760930 cites W2065034858 @default.
- W2059760930 cites W2067115616 @default.
- W2059760930 cites W2068600461 @default.
- W2059760930 cites W2068832783 @default.