FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059775504> ?p ?o ?g. }

• W2059775504 endingPage "712" @default.
• W2059775504 startingPage "703" @default.
• W2059775504 abstract "Methylene blue (MB) has been used clinically for about a century to treat numerous ailments. We show that MB and other diaminophenothiazines extend the life span of human IMR90 fibroblasts in tissue culture by >20 population doubling (PDLs). MB delays senescence at nM levels in IMR90 by enhancing mitochondrial function. MB increases mitochondrial complex IV by 30%, enhances cellular oxygen consumption by 37-70%, increases heme synthesis, and reverses premature senescence caused by H2O2 or cadmium. MB also induces phase-2 antioxidant enzymes in hepG2 cells. Flavin-dependent enzymes are known to use NAD(P)H to reduce MB to leucomethylene blue (MBH2), whereas cytochrome c reoxidizes MBH2 to MB. Experiments on lysates from rat liver mitochondria suggest the ratio MB/cytochrome c is important for the protective actions of MB. We propose that the cellular senescence delay caused by MB is due to cycling between MB and MBH2 in mitochondria, which may partly explain the increase in specific mitochondrial activities. Cycling of MB between oxidized and reduced forms may block oxidant production by mitochondria. Mitochondrial dysfunction and oxidative stress are thought to be key aberrations that lead to cellular senescence and aging. MB may be useful to delay mitochondrial dysfunction with aging and the decrease in complex IV in Alzheimer disease." @default.
• W2059775504 created "2016-06-24" @default.
• W2059775504 creator A5004879671 @default.
• W2059775504 creator A5008007920 @default.
• W2059775504 creator A5023194178 @default.
• W2059775504 creator A5035665075 @default.
• W2059775504 creator A5039480322 @default.
• W2059775504 creator A5047067531 @default.
• W2059775504 creator A5062030862 @default.
• W2059775504 date "2007-10-10" @default.
• W2059775504 modified "2023-09-30" @default.
• W2059775504 title "Methylene blue delays cellular senescence and enhances key mitochondrial biochemical pathways" @default.
• W2059775504 cites W1516582678 @default.
• W2059775504 cites W1548136782 @default.
• W2059775504 cites W1549319248 @default.
• W2059775504 cites W1600608574 @default.
• W2059775504 cites W1737297041 @default.
• W2059775504 cites W1964659057 @default.
• W2059775504 cites W1972179067 @default.
• W2059775504 cites W1977528358 @default.
• W2059775504 cites W1980351992 @default.
• W2059775504 cites W1984798609 @default.
• W2059775504 cites W1986148649 @default.
• W2059775504 cites W1986241485 @default.
• W2059775504 cites W1989307054 @default.
• W2059775504 cites W1991631628 @default.
• W2059775504 cites W1994097764 @default.
• W2059775504 cites W1994681448 @default.
• W2059775504 cites W1996592443 @default.
• W2059775504 cites W2004759032 @default.
• W2059775504 cites W2009421118 @default.
• W2059775504 cites W2015558578 @default.
• W2059775504 cites W2024385804 @default.
• W2059775504 cites W2031383268 @default.
• W2059775504 cites W2031400881 @default.
• W2059775504 cites W2033804816 @default.
• W2059775504 cites W2047906602 @default.
• W2059775504 cites W2048691381 @default.
• W2059775504 cites W2050118590 @default.
• W2059775504 cites W2051041701 @default.
• W2059775504 cites W2054223377 @default.
• W2059775504 cites W2056014680 @default.
• W2059775504 cites W2056789677 @default.
• W2059775504 cites W2058056447 @default.
• W2059775504 cites W2064456239 @default.
• W2059775504 cites W2068603132 @default.
• W2059775504 cites W2086557226 @default.
• W2059775504 cites W2089237000 @default.
• W2059775504 cites W2090068194 @default.
• W2059775504 cites W2090920404 @default.
• W2059775504 cites W2093476222 @default.
• W2059775504 cites W2094026727 @default.
• W2059775504 cites W2094295607 @default.
• W2059775504 cites W2102163574 @default.
• W2059775504 cites W2105532922 @default.
• W2059775504 cites W2109192679 @default.
• W2059775504 cites W2125741214 @default.
• W2059775504 cites W2134241543 @default.
• W2059775504 cites W2167029847 @default.
• W2059775504 cites W2264489409 @default.
• W2059775504 cites W4234139408 @default.
• W2059775504 cites W4244624554 @default.
• W2059775504 cites W4250743572 @default.
• W2059775504 cites W2419569297 @default.
• W2059775504 doi "https://doi.org/10.1096/fj.07-9610com" @default.
• W2059775504 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17928358" @default.
• W2059775504 hasPublicationYear "2007" @default.
• W2059775504 type Work @default.
• W2059775504 sameAs 2059775504 @default.
• W2059775504 citedByCount "238" @default.
• W2059775504 countsByYear W20597755042012 @default.
• W2059775504 countsByYear W20597755042013 @default.
• W2059775504 countsByYear W20597755042014 @default.
• W2059775504 countsByYear W20597755042015 @default.
• W2059775504 countsByYear W20597755042016 @default.
• W2059775504 countsByYear W20597755042017 @default.
• W2059775504 countsByYear W20597755042018 @default.
• W2059775504 countsByYear W20597755042019 @default.
• W2059775504 countsByYear W20597755042020 @default.
• W2059775504 countsByYear W20597755042021 @default.
• W2059775504 countsByYear W20597755042022 @default.
• W2059775504 countsByYear W20597755042023 @default.
• W2059775504 crossrefType "journal-article" @default.
• W2059775504 hasAuthorship W2059775504A5004879671 @default.
• W2059775504 hasAuthorship W2059775504A5008007920 @default.
• W2059775504 hasAuthorship W2059775504A5023194178 @default.
• W2059775504 hasAuthorship W2059775504A5035665075 @default.
• W2059775504 hasAuthorship W2059775504A5039480322 @default.
• W2059775504 hasAuthorship W2059775504A5047067531 @default.
• W2059775504 hasAuthorship W2059775504A5062030862 @default.
• W2059775504 hasConcept C123249941 @default.
• W2059775504 hasConcept C185592680 @default.
• W2059775504 hasConcept C2776151105 @default.
• W2059775504 hasConcept C28859421 @default.
• W2059775504 hasConcept C2908647359 @default.
• W2059775504 hasConcept C48349386 @default.
• W2059775504 hasConcept C522857546 @default.
• W2059775504 hasConcept C55493867 @default.

• next