FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059777325> ?p ?o ?g. }

• W2059777325 endingPage "1158" @default.
• W2059777325 startingPage "1153" @default.
• W2059777325 abstract "Downregulation of Notch1 has been shown to exert antineoplastic effects in vivo and in vitro. However, the role of the Notch1 gene in the proliferative and invasive ability of gastric cancer cells is not clear. In this study, we investigated the effect of Notch1 gene silencing on the proliferation and invasion of gastric cancer SGC‑7901 cells. Small interfering RNA (siRNA) targeting Notch1 was transfected into SGC‑7901 cells using Lipofectamine 2000. Proliferation of SGC‑7901 cells was then determined by the MTT assay. Notch1 mRNA expression was determined by reverse transcription‑polymerase chain reaction (RT‑PCR). Invasion of the SGC‑7901 cells was detected by the Transwell assay. The protein levels of cyclin D1, cyclin A1 and cyclin-dependent kinase 2 (CDK2) were determined by western blotting. The mRNA levels of matrix metalloproteinase‑2 (MMP‑2) and cyclooxygenase‑2 (COX‑2) were determined by RT‑PCR. Compared to the control group, the Notch1 mRNA level was significantly decreased following transfection. The growth and invasion rates of SGC‑7901 cells were significantly reduced after Notch1 silencing. Additionally, the expression of cyclin D1 and cyclin A1 proteins and of the MMP‑2 and COX‑2 mRNAs was markedly attenuated. From these results, it was concluded that Notch1 gene silencing inhibits the proliferation of gastric SGC‑7901 cells by decreasing the expression of cyclins D1 and A1, and reduces the invasive ability of SGC‑7901 cells through the downregulation of MMP‑2 and COX‑2 genes. Thus, silencing of the Notch1 pathway may be a novel approach in the treatment of gastrointestinal cancer." @default.
• W2059777325 created "2016-06-24" @default.
• W2059777325 creator A5021549809 @default.
• W2059777325 creator A5029127693 @default.
• W2059777325 creator A5040840218 @default.
• W2059777325 creator A5042437367 @default.
• W2059777325 creator A5057944711 @default.
• W2059777325 creator A5066028215 @default.
• W2059777325 creator A5070439007 @default.
• W2059777325 date "2014-01-28" @default.
• W2059777325 modified "2023-10-16" @default.
• W2059777325 title "Notch1 silencing inhibits proliferation and invasion in SGC-7901 gastric cancer cells" @default.
• W2059777325 cites W1576469977 @default.
• W2059777325 cites W178977003 @default.
• W2059777325 cites W1942403634 @default.
• W2059777325 cites W1995004385 @default.
• W2059777325 cites W1997801717 @default.
• W2059777325 cites W1999684691 @default.
• W2059777325 cites W200461197 @default.
• W2059777325 cites W2006271108 @default.
• W2059777325 cites W2008818697 @default.
• W2059777325 cites W2020295576 @default.
• W2059777325 cites W2036100227 @default.
• W2059777325 cites W2038977174 @default.
• W2059777325 cites W2048304719 @default.
• W2059777325 cites W2069706769 @default.
• W2059777325 cites W2071177287 @default.
• W2059777325 cites W2073653528 @default.
• W2059777325 cites W2085564476 @default.
• W2059777325 cites W2104014368 @default.
• W2059777325 cites W2112315511 @default.
• W2059777325 cites W2136395235 @default.
• W2059777325 cites W2144030304 @default.
• W2059777325 cites W2144169031 @default.
• W2059777325 cites W2146677771 @default.
• W2059777325 cites W2159892503 @default.
• W2059777325 cites W2161817637 @default.
• W2059777325 cites W2170785598 @default.
• W2059777325 cites W4255997358 @default.
• W2059777325 doi "https://doi.org/10.3892/mmr.2014.1920" @default.
• W2059777325 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24469571" @default.
• W2059777325 hasPublicationYear "2014" @default.
• W2059777325 type Work @default.
• W2059777325 sameAs 2059777325 @default.
• W2059777325 citedByCount "13" @default.
• W2059777325 countsByYear W20597773252014 @default.
• W2059777325 countsByYear W20597773252015 @default.
• W2059777325 countsByYear W20597773252016 @default.
• W2059777325 countsByYear W20597773252017 @default.
• W2059777325 countsByYear W20597773252019 @default.
• W2059777325 countsByYear W20597773252020 @default.
• W2059777325 countsByYear W20597773252021 @default.
• W2059777325 countsByYear W20597773252022 @default.
• W2059777325 crossrefType "journal-article" @default.
• W2059777325 hasAuthorship W2059777325A5021549809 @default.
• W2059777325 hasAuthorship W2059777325A5029127693 @default.
• W2059777325 hasAuthorship W2059777325A5040840218 @default.
• W2059777325 hasAuthorship W2059777325A5042437367 @default.
• W2059777325 hasAuthorship W2059777325A5057944711 @default.
• W2059777325 hasAuthorship W2059777325A5066028215 @default.
• W2059777325 hasAuthorship W2059777325A5070439007 @default.
• W2059777325 hasBestOaLocation W20597773251 @default.
• W2059777325 hasConcept C104317684 @default.
• W2059777325 hasConcept C119056186 @default.
• W2059777325 hasConcept C121608353 @default.
• W2059777325 hasConcept C127561419 @default.
• W2059777325 hasConcept C1491633281 @default.
• W2059777325 hasConcept C153911025 @default.
• W2059777325 hasConcept C185592680 @default.
• W2059777325 hasConcept C199835354 @default.
• W2059777325 hasConcept C22615655 @default.
• W2059777325 hasConcept C2781018059 @default.
• W2059777325 hasConcept C29537977 @default.
• W2059777325 hasConcept C502942594 @default.
• W2059777325 hasConcept C54009773 @default.
• W2059777325 hasConcept C54355233 @default.
• W2059777325 hasConcept C55493867 @default.
• W2059777325 hasConcept C62112901 @default.
• W2059777325 hasConcept C81885089 @default.
• W2059777325 hasConcept C86803240 @default.
• W2059777325 hasConcept C96232424 @default.
• W2059777325 hasConceptScore W2059777325C104317684 @default.
• W2059777325 hasConceptScore W2059777325C119056186 @default.
• W2059777325 hasConceptScore W2059777325C121608353 @default.
• W2059777325 hasConceptScore W2059777325C127561419 @default.
• W2059777325 hasConceptScore W2059777325C1491633281 @default.
• W2059777325 hasConceptScore W2059777325C153911025 @default.
• W2059777325 hasConceptScore W2059777325C185592680 @default.
• W2059777325 hasConceptScore W2059777325C199835354 @default.
• W2059777325 hasConceptScore W2059777325C22615655 @default.
• W2059777325 hasConceptScore W2059777325C2781018059 @default.
• W2059777325 hasConceptScore W2059777325C29537977 @default.
• W2059777325 hasConceptScore W2059777325C502942594 @default.
• W2059777325 hasConceptScore W2059777325C54009773 @default.
• W2059777325 hasConceptScore W2059777325C54355233 @default.
• W2059777325 hasConceptScore W2059777325C55493867 @default.
• W2059777325 hasConceptScore W2059777325C62112901 @default.
• W2059777325 hasConceptScore W2059777325C81885089 @default.

• next