FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059780090> ?p ?o ?g. }

• W2059780090 endingPage "720" @default.
• W2059780090 startingPage "716" @default.
• W2059780090 abstract "Gain-of-function mutations of the c-kit gene and the expression of phosphorylated KIT are found in most gastrointestinal stromal tumors and mastocytosis. Further, almost all gonadal seminomas/dysgerminomas exhibit KIT membranous staining, and several reports have clarified that some (10-25%) have a c-kit gene mutation. But, whether intracranial germinomas also have a c-kit gene mutation remains unsolved. To elucidate the presence, frequency, and location of c-kit gene mutations in intracranial germinomas, we analyzed five mutational hot spots (exons 9, 10, 11, 13, and 17) in the c-kit genomic DNA of 16 germinomas using polymerase chain reaction and direct sequencing. We found c-kit gene mutations at exon 11 (W557C) or 17 (D816V, D820V, and N822Y) in four germinomas (25.0%), although no statistically significant difference in any clinicopathological factor was found between patients with or without mutations. These results are similar to those seen in gonadal seminoma/dysgerminoma patients, and confirm that intracranial germinomas are exact counterparts of gonadal seminomas/dysgerminomas, as would be expected on histological and immunohistochemical grounds. Moreover, molecular targeting drugs such as imatinib mesylate (STI571), which is a selective inhibitor of KIT, might be promising agents for the treatment of intracranial germinomas with c-kit gene mutations." @default.
• W2059780090 created "2016-06-24" @default.
• W2059780090 creator A5018139084 @default.
• W2059780090 creator A5029513678 @default.
• W2059780090 creator A5063352822 @default.
• W2059780090 creator A5067592383 @default.
• W2059780090 creator A5076142771 @default.
• W2059780090 creator A5083526964 @default.
• W2059780090 date "2004-09-01" @default.
• W2059780090 modified "2023-10-16" @default.
• W2059780090 title "c-kit gene mutations in intracranial germinomas" @default.
• W2059780090 cites W1972284797 @default.
• W2059780090 cites W1983879963 @default.
• W2059780090 cites W1985872661 @default.
• W2059780090 cites W2000998080 @default.
• W2059780090 cites W2003282189 @default.
• W2059780090 cites W2011144636 @default.
• W2059780090 cites W2015015957 @default.
• W2059780090 cites W2016899343 @default.
• W2059780090 cites W2021997509 @default.
• W2059780090 cites W2028367089 @default.
• W2059780090 cites W2037957809 @default.
• W2059780090 cites W2038961612 @default.
• W2059780090 cites W2039037540 @default.
• W2059780090 cites W2046528722 @default.
• W2059780090 cites W2073325887 @default.
• W2059780090 cites W2077976050 @default.
• W2059780090 cites W2081007495 @default.
• W2059780090 cites W2085001173 @default.
• W2059780090 cites W2094577660 @default.
• W2059780090 cites W2095226581 @default.
• W2059780090 cites W2105396280 @default.
• W2059780090 cites W2106037057 @default.
• W2059780090 cites W2119455657 @default.
• W2059780090 cites W2127405017 @default.
• W2059780090 cites W2130755604 @default.
• W2059780090 cites W2139524845 @default.
• W2059780090 cites W2150501295 @default.
• W2059780090 cites W2153554853 @default.
• W2059780090 cites W2156160133 @default.
• W2059780090 cites W2165720262 @default.
• W2059780090 cites W2171620774 @default.
• W2059780090 doi "https://doi.org/10.1111/j.1349-7006.2004.tb03251.x" @default.
• W2059780090 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15471556" @default.
• W2059780090 hasPublicationYear "2004" @default.
• W2059780090 type Work @default.
• W2059780090 sameAs 2059780090 @default.
• W2059780090 citedByCount "67" @default.
• W2059780090 countsByYear W20597800902012 @default.
• W2059780090 countsByYear W20597800902013 @default.
• W2059780090 countsByYear W20597800902014 @default.
• W2059780090 countsByYear W20597800902015 @default.
• W2059780090 countsByYear W20597800902016 @default.
• W2059780090 countsByYear W20597800902017 @default.
• W2059780090 countsByYear W20597800902018 @default.
• W2059780090 countsByYear W20597800902020 @default.
• W2059780090 countsByYear W20597800902021 @default.
• W2059780090 countsByYear W20597800902023 @default.
• W2059780090 crossrefType "journal-article" @default.
• W2059780090 hasAuthorship W2059780090A5018139084 @default.
• W2059780090 hasAuthorship W2059780090A5029513678 @default.
• W2059780090 hasAuthorship W2059780090A5063352822 @default.
• W2059780090 hasAuthorship W2059780090A5067592383 @default.
• W2059780090 hasAuthorship W2059780090A5076142771 @default.
• W2059780090 hasAuthorship W2059780090A5083526964 @default.
• W2059780090 hasBestOaLocation W20597800901 @default.
• W2059780090 hasConcept C104317684 @default.
• W2059780090 hasConcept C142724271 @default.
• W2059780090 hasConcept C153911025 @default.
• W2059780090 hasConcept C2776252090 @default.
• W2059780090 hasConcept C2777583451 @default.
• W2059780090 hasConcept C2778324911 @default.
• W2059780090 hasConcept C2778729363 @default.
• W2059780090 hasConcept C2994225774 @default.
• W2059780090 hasConcept C3019892230 @default.
• W2059780090 hasConcept C36823959 @default.
• W2059780090 hasConcept C501734568 @default.
• W2059780090 hasConcept C502942594 @default.
• W2059780090 hasConcept C54355233 @default.
• W2059780090 hasConcept C71924100 @default.
• W2059780090 hasConcept C86803240 @default.
• W2059780090 hasConceptScore W2059780090C104317684 @default.
• W2059780090 hasConceptScore W2059780090C142724271 @default.
• W2059780090 hasConceptScore W2059780090C153911025 @default.
• W2059780090 hasConceptScore W2059780090C2776252090 @default.
• W2059780090 hasConceptScore W2059780090C2777583451 @default.
• W2059780090 hasConceptScore W2059780090C2778324911 @default.
• W2059780090 hasConceptScore W2059780090C2778729363 @default.
• W2059780090 hasConceptScore W2059780090C2994225774 @default.
• W2059780090 hasConceptScore W2059780090C3019892230 @default.
• W2059780090 hasConceptScore W2059780090C36823959 @default.
• W2059780090 hasConceptScore W2059780090C501734568 @default.
• W2059780090 hasConceptScore W2059780090C502942594 @default.
• W2059780090 hasConceptScore W2059780090C54355233 @default.
• W2059780090 hasConceptScore W2059780090C71924100 @default.
• W2059780090 hasConceptScore W2059780090C86803240 @default.
• W2059780090 hasIssue "9" @default.
• W2059780090 hasLocation W20597800901 @default.

• next