Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059784857> ?p ?o ?g. }
- W2059784857 endingPage "4611" @default.
- W2059784857 startingPage "4603" @default.
- W2059784857 abstract "Vascular endothelial growth factor (VEGF) exerts its biological effects by binding to the tyrosine kinase receptors VEGF receptor type 1 (VEGFR1/Flt-1) and VEGFR2 (Flk-1/KDR). Kinase insert domain receptor (KDR) is the critical receptor controlling proliferation and migration of endothelial cells and has been shown to be expressed in some nonendothelial cells. We recently reported that the proangiogenic pituitary tumor transforming gene (PTTG) stimulates VEGF and up-regulates inhibitor of DNA binding-3 (ID3), an important gene in VEGF-dependent angiogenesis.Our objective was to test whether VEGF, ID3, and KDR confer a PTTG-mediated effect on thyroid cell growth.Gene expression, MAPK stimulation, and cell proliferation were assessed in follicular thyroid cancer FTC133 cells. Gene expression and clinical associations were determined in 21 normal and 38 tumorous thyroid specimens (nine follicular and 29 papillary).ID3 correlated with VEGF mRNA expression in our series of thyroid cancers, which also showed up-regulated KDR mRNA. Stimulation of FTC133 cells with exogenous VEGF enhanced ID3 expression, which could be abrogated by the KDR-specific inhibitor ZM323881, suggesting that VEGF regulation of ID3 is KDR dependent. PTTG significantly correlated with KDR mRNA expression in our thyroid cancer cohort and up-regulated KDR and VEGF expression in FTC133 cells. Finally, cells transfected with PTTG demonstrated increased cell proliferation and phosphorylation of MAPK, which was abrogated by ZM323881.We report the presence of a VEGF/KDR/ID3-dependent autocrine pathway in FTC133 thyroid cells. By up-regulating both VEGF and KDR expression, we propose a novel PTTG-mediated proliferative pathway that may be critical to thyroid cancer growth and progression." @default.
- W2059784857 created "2016-06-24" @default.
- W2059784857 creator A5009389483 @default.
- W2059784857 creator A5015317444 @default.
- W2059784857 creator A5023701755 @default.
- W2059784857 creator A5043445659 @default.
- W2059784857 creator A5057139017 @default.
- W2059784857 creator A5090508179 @default.
- W2059784857 date "2006-11-01" @default.
- W2059784857 modified "2023-10-14" @default.
- W2059784857 title "Pituitary Tumor Transforming Gene (PTTG) Stimulates Thyroid Cell Proliferation via a Vascular Endothelial Growth Factor/Kinase Insert Domain Receptor/Inhibitor of DNA Binding-3 Autocrine Pathway" @default.
- W2059784857 cites W1679229092 @default.
- W2059784857 cites W1868947797 @default.
- W2059784857 cites W1975957264 @default.
- W2059784857 cites W1978404812 @default.
- W2059784857 cites W1982060502 @default.
- W2059784857 cites W1985325453 @default.
- W2059784857 cites W1985712533 @default.
- W2059784857 cites W1991321447 @default.
- W2059784857 cites W2011293778 @default.
- W2059784857 cites W2017520393 @default.
- W2059784857 cites W2032269759 @default.
- W2059784857 cites W2035127867 @default.
- W2059784857 cites W2037761545 @default.
- W2059784857 cites W2038197766 @default.
- W2059784857 cites W2048878899 @default.
- W2059784857 cites W2049427614 @default.
- W2059784857 cites W2049792558 @default.
- W2059784857 cites W2068857334 @default.
- W2059784857 cites W2076058111 @default.
- W2059784857 cites W2078083828 @default.
- W2059784857 cites W2080149096 @default.
- W2059784857 cites W2083005649 @default.
- W2059784857 cites W2084844081 @default.
- W2059784857 cites W2087523741 @default.
- W2059784857 cites W2093774214 @default.
- W2059784857 cites W2097585410 @default.
- W2059784857 cites W2107380496 @default.
- W2059784857 cites W2114185454 @default.
- W2059784857 cites W2121247112 @default.
- W2059784857 cites W2123678305 @default.
- W2059784857 cites W2124068536 @default.
- W2059784857 cites W2127339144 @default.
- W2059784857 cites W2138020607 @default.
- W2059784857 cites W2142752142 @default.
- W2059784857 cites W2146513771 @default.
- W2059784857 cites W2154082643 @default.
- W2059784857 cites W2158743409 @default.
- W2059784857 cites W2159403437 @default.
- W2059784857 cites W2165158801 @default.
- W2059784857 cites W2169792450 @default.
- W2059784857 cites W2171351760 @default.
- W2059784857 doi "https://doi.org/10.1210/jc.2006-1291" @default.
- W2059784857 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16926250" @default.
- W2059784857 hasPublicationYear "2006" @default.
- W2059784857 type Work @default.
- W2059784857 sameAs 2059784857 @default.
- W2059784857 citedByCount "31" @default.
- W2059784857 countsByYear W20597848572012 @default.
- W2059784857 countsByYear W20597848572013 @default.
- W2059784857 countsByYear W20597848572014 @default.
- W2059784857 countsByYear W20597848572015 @default.
- W2059784857 countsByYear W20597848572016 @default.
- W2059784857 countsByYear W20597848572018 @default.
- W2059784857 countsByYear W20597848572019 @default.
- W2059784857 countsByYear W20597848572020 @default.
- W2059784857 crossrefType "journal-article" @default.
- W2059784857 hasAuthorship W2059784857A5009389483 @default.
- W2059784857 hasAuthorship W2059784857A5015317444 @default.
- W2059784857 hasAuthorship W2059784857A5023701755 @default.
- W2059784857 hasAuthorship W2059784857A5043445659 @default.
- W2059784857 hasAuthorship W2059784857A5057139017 @default.
- W2059784857 hasAuthorship W2059784857A5090508179 @default.
- W2059784857 hasBestOaLocation W20597848571 @default.
- W2059784857 hasConcept C126322002 @default.
- W2059784857 hasConcept C128240485 @default.
- W2059784857 hasConcept C134018914 @default.
- W2059784857 hasConcept C146285616 @default.
- W2059784857 hasConcept C14858245 @default.
- W2059784857 hasConcept C167734588 @default.
- W2059784857 hasConcept C170493617 @default.
- W2059784857 hasConcept C2777025900 @default.
- W2059784857 hasConcept C2779341817 @default.
- W2059784857 hasConcept C2779761222 @default.
- W2059784857 hasConcept C2780394083 @default.
- W2059784857 hasConcept C2781461381 @default.
- W2059784857 hasConcept C502942594 @default.
- W2059784857 hasConcept C526584372 @default.
- W2059784857 hasConcept C71924100 @default.
- W2059784857 hasConcept C86803240 @default.
- W2059784857 hasConceptScore W2059784857C126322002 @default.
- W2059784857 hasConceptScore W2059784857C128240485 @default.
- W2059784857 hasConceptScore W2059784857C134018914 @default.
- W2059784857 hasConceptScore W2059784857C146285616 @default.
- W2059784857 hasConceptScore W2059784857C14858245 @default.
- W2059784857 hasConceptScore W2059784857C167734588 @default.
- W2059784857 hasConceptScore W2059784857C170493617 @default.
- W2059784857 hasConceptScore W2059784857C2777025900 @default.