FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059787887> ?p ?o ?g. }

• W2059787887 endingPage "68" @default.
• W2059787887 startingPage "60" @default.
• W2059787887 abstract "WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • There is interindividual variability in the antilymphocyte globulin (ALG) effect, but there is no pharmacokinetic–pharmacodynamic study of this subject. • In addition, a time dependence of the pharmacokinetics of some therapeutic antibodies has been described. • ALGs may partly act by antibody-dependent cellular cytotoxicity (ADCC), but their mechanism of action in humans is not known. WHAT THIS STUDY ADDS • Horse ALG pharmacokinetics can be described using a two-compartment model with time-dependent central volume of distribution. • After an initial concentration-independent lymphocyte depletion, the concentration–effect relationship can be described using a physiological indirect response model. • The genetic polymorphism of FcγRIIIa at position 158 may influence the ALG concentration–effect relationship and these polyclonal antibodies may therefore act by ADCC. AIMS Polyclonal antilymphocyte globulins (ALGs) are currently used in transplantation, but the sources of interindividual variability of their effect are poorly understood. No pharmacokinetic–pharmacodynamic (PK–PD) study of ALG is available. Moreover, the genetic polymorphism of FcγRIIIa, a receptor for the Fc portion of immunoglobulins involved in antibody-dependent cellular cytotoxicity (ADCC), may influence their concentration–effect relationship. METHODS Fourteen kidney transplant patients treated by horse ALG were included in a prospective, noncomparative study. A population two-compartment PK model including a time dependence of the central volume of distribution was developed. Total lymphocyte count was used as biomarker of effect. Concentration–effect data were described using a physiological indirect response model, combining concentration-dependent and -independent inhibitions of lymphocyte input into the circulation. In addition, six kidney transplant patients in whom ALG concentrations were not available were included retrospectively. All patients were genotyped for FCGR3A. RESULTS Both the PK and the PK–PD model described the data satisfactorily and showed high interindividual variability. Asymptotic T1/2-α and T1/2-β-values were 1.3 and 25 days, respectively. The concentration of ALG leading to a 50% inhibition of lymphocyte input (IC50) was lower in FCGR3A-V carriers than in FCGR3A-F/F patients (383 ± 199 vs. 593 ± 209 mg l−1, P = 0.008). CONCLUSIONS This is the first description of the ALG effect on lymphocyte count using PK–PD modelling. Our results show that part of the variability in their concentration–effect relationship may be explained by FcγRIIIa genetic polymorphism and therefore that horse ALG may deplete lymphocytes by ADCC." @default.
• W2059787887 created "2016-06-24" @default.
• W2059787887 creator A5008875970 @default.
• W2059787887 creator A5011831250 @default.
• W2059787887 creator A5015005652 @default.
• W2059787887 creator A5028831197 @default.
• W2059787887 creator A5029607656 @default.
• W2059787887 creator A5033266569 @default.
• W2059787887 creator A5039278929 @default.
• W2059787887 creator A5041246808 @default.
• W2059787887 creator A5060790711 @default.
• W2059787887 creator A5060995313 @default.
• W2059787887 creator A5084887934 @default.
• W2059787887 date "2008-01-01" @default.
• W2059787887 modified "2023-10-17" @default.
• W2059787887 title "Interindividual variability in the concentration-effect relationship of antilymphocyte globulins-a possible influence of FcγRIIIa genetic polymorphism" @default.
• W2059787887 cites W110134616 @default.
• W2059787887 cites W1914229355 @default.
• W2059787887 cites W1963935236 @default.
• W2059787887 cites W1965962344 @default.
• W2059787887 cites W1967221084 @default.
• W2059787887 cites W1970759336 @default.
• W2059787887 cites W1971917654 @default.
• W2059787887 cites W1976652440 @default.
• W2059787887 cites W1985701112 @default.
• W2059787887 cites W2006499806 @default.
• W2059787887 cites W2024326702 @default.
• W2059787887 cites W2032470082 @default.
• W2059787887 cites W2034384773 @default.
• W2059787887 cites W2043946207 @default.
• W2059787887 cites W2044360617 @default.
• W2059787887 cites W2048121694 @default.
• W2059787887 cites W2057836361 @default.
• W2059787887 cites W2069065837 @default.
• W2059787887 cites W2083039283 @default.
• W2059787887 cites W2095955743 @default.
• W2059787887 cites W2099704507 @default.
• W2059787887 cites W2109502548 @default.
• W2059787887 cites W2109638333 @default.
• W2059787887 cites W2111395979 @default.
• W2059787887 cites W2117815681 @default.
• W2059787887 cites W2119751753 @default.
• W2059787887 cites W2152107828 @default.
• W2059787887 cites W2262851522 @default.
• W2059787887 cites W2413050760 @default.
• W2059787887 cites W4242073515 @default.
• W2059787887 doi "https://doi.org/10.1111/j.1365-2125.2007.02967.x" @default.
• W2059787887 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2291273" @default.
• W2059787887 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17610526" @default.
• W2059787887 hasPublicationYear "2008" @default.
• W2059787887 type Work @default.
• W2059787887 sameAs 2059787887 @default.
• W2059787887 citedByCount "11" @default.
• W2059787887 countsByYear W20597878872013 @default.
• W2059787887 countsByYear W20597878872014 @default.
• W2059787887 countsByYear W20597878872016 @default.
• W2059787887 countsByYear W20597878872018 @default.
• W2059787887 countsByYear W20597878872019 @default.
• W2059787887 countsByYear W20597878872020 @default.
• W2059787887 countsByYear W20597878872021 @default.
• W2059787887 crossrefType "journal-article" @default.
• W2059787887 hasAuthorship W2059787887A5008875970 @default.
• W2059787887 hasAuthorship W2059787887A5011831250 @default.
• W2059787887 hasAuthorship W2059787887A5015005652 @default.
• W2059787887 hasAuthorship W2059787887A5028831197 @default.
• W2059787887 hasAuthorship W2059787887A5029607656 @default.
• W2059787887 hasAuthorship W2059787887A5033266569 @default.
• W2059787887 hasAuthorship W2059787887A5039278929 @default.
• W2059787887 hasAuthorship W2059787887A5041246808 @default.
• W2059787887 hasAuthorship W2059787887A5060790711 @default.
• W2059787887 hasAuthorship W2059787887A5060995313 @default.
• W2059787887 hasAuthorship W2059787887A5084887934 @default.
• W2059787887 hasBestOaLocation W20597878871 @default.
• W2059787887 hasConcept C111113717 @default.
• W2059787887 hasConcept C112705442 @default.
• W2059787887 hasConcept C126322002 @default.
• W2059787887 hasConcept C139254425 @default.
• W2059787887 hasConcept C159654299 @default.
• W2059787887 hasConcept C185592680 @default.
• W2059787887 hasConcept C203014093 @default.
• W2059787887 hasConcept C2777761686 @default.
• W2059787887 hasConcept C2908647359 @default.
• W2059787887 hasConcept C2911091166 @default.
• W2059787887 hasConcept C40677261 @default.
• W2059787887 hasConcept C542903549 @default.
• W2059787887 hasConcept C71924100 @default.
• W2059787887 hasConcept C81358767 @default.
• W2059787887 hasConcept C956191 @default.
• W2059787887 hasConcept C98274493 @default.
• W2059787887 hasConcept C99454951 @default.
• W2059787887 hasConceptScore W2059787887C111113717 @default.
• W2059787887 hasConceptScore W2059787887C112705442 @default.
• W2059787887 hasConceptScore W2059787887C126322002 @default.
• W2059787887 hasConceptScore W2059787887C139254425 @default.
• W2059787887 hasConceptScore W2059787887C159654299 @default.
• W2059787887 hasConceptScore W2059787887C185592680 @default.
• W2059787887 hasConceptScore W2059787887C203014093 @default.
• W2059787887 hasConceptScore W2059787887C2777761686 @default.

• next