FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059790042> ?p ?o ?g. }

• W2059790042 endingPage "1632" @default.
• W2059790042 startingPage "1628" @default.
• W2059790042 abstract "Precise patterning of cell types along the dorsal-ventral axis of the spinal cord is essential to establish functional neural circuits [1Jessell T.M. Neuronal specification in the spinal cord inductive signals and transcriptional codes.Nat. Rev. Genet. 2000; 1: 20-29Crossref PubMed Scopus (1552) Google Scholar]. In order to prove the feasibility of studying a single biological process through random mutagenesis in the mouse, we have identified recessive ENU-induced mutations in six genes that prevent normal specification of ventral cell types in the spinal cord. We positionally cloned the genes responsible for two of the mutant phenotypes, smoothened and dispatched, which are homologs of Drosophila Hh pathway components. The Dispatched homolog1 (Disp1) mutation causes lethality at midgestation and prevents specification of ventral cell types in the neural tube, a phenotype identical to the Smoothened (Smo) null phenotype. As in Drosophila, mouse Disp1 is required to move Shh away from the site of synthesis. Despite the existence of a second mouse disp homolog, Disp1 is essential for long-range signaling by both Shh and Ihh ligands. Our data indicate that Shh signaling is required within the notochord to maintain Shh expression and to prevent notochord degeneration. Disp1, unlike Smo, is not required for this juxtacrine signaling by Shh." @default.
• W2059790042 created "2016-06-24" @default.
• W2059790042 creator A5013638496 @default.
• W2059790042 creator A5017645722 @default.
• W2059790042 creator A5025136463 @default.
• W2059790042 creator A5033047559 @default.
• W2059790042 creator A5046188913 @default.
• W2059790042 creator A5050330921 @default.
• W2059790042 creator A5075064478 @default.
• W2059790042 creator A5077165179 @default.
• W2059790042 date "2002-09-01" @default.
• W2059790042 modified "2023-10-17" @default.
• W2059790042 title "Mouse Dispatched homolog1 Is Required for Long-Range, but Not Juxtacrine, Hh Signaling" @default.
• W2059790042 cites W1900580575 @default.
• W2059790042 cites W1930652382 @default.
• W2059790042 cites W1968717680 @default.
• W2059790042 cites W1976551834 @default.
• W2059790042 cites W1982824007 @default.
• W2059790042 cites W1983341583 @default.
• W2059790042 cites W1988958937 @default.
• W2059790042 cites W1997862931 @default.
• W2059790042 cites W2010863761 @default.
• W2059790042 cites W2026550373 @default.
• W2059790042 cites W2028497134 @default.
• W2059790042 cites W2032855297 @default.
• W2059790042 cites W2054428566 @default.
• W2059790042 cites W2059614045 @default.
• W2059790042 cites W2081235375 @default.
• W2059790042 cites W2087022717 @default.
• W2059790042 cites W2102345821 @default.
• W2059790042 cites W2107194582 @default.
• W2059790042 cites W2115840790 @default.
• W2059790042 cites W2120684043 @default.
• W2059790042 cites W2136641275 @default.
• W2059790042 cites W2160889747 @default.
• W2059790042 cites W2164310262 @default.
• W2059790042 doi "https://doi.org/10.1016/s0960-9822(02)01147-8" @default.
• W2059790042 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12372258" @default.
• W2059790042 hasPublicationYear "2002" @default.
• W2059790042 type Work @default.
• W2059790042 sameAs 2059790042 @default.
• W2059790042 citedByCount "173" @default.
• W2059790042 countsByYear W20597900422012 @default.
• W2059790042 countsByYear W20597900422013 @default.
• W2059790042 countsByYear W20597900422014 @default.
• W2059790042 countsByYear W20597900422015 @default.
• W2059790042 countsByYear W20597900422016 @default.
• W2059790042 countsByYear W20597900422017 @default.
• W2059790042 countsByYear W20597900422018 @default.
• W2059790042 countsByYear W20597900422019 @default.
• W2059790042 countsByYear W20597900422020 @default.
• W2059790042 countsByYear W20597900422021 @default.
• W2059790042 countsByYear W20597900422022 @default.
• W2059790042 countsByYear W20597900422023 @default.
• W2059790042 crossrefType "journal-article" @default.
• W2059790042 hasAuthorship W2059790042A5013638496 @default.
• W2059790042 hasAuthorship W2059790042A5017645722 @default.
• W2059790042 hasAuthorship W2059790042A5025136463 @default.
• W2059790042 hasAuthorship W2059790042A5033047559 @default.
• W2059790042 hasAuthorship W2059790042A5046188913 @default.
• W2059790042 hasAuthorship W2059790042A5050330921 @default.
• W2059790042 hasAuthorship W2059790042A5075064478 @default.
• W2059790042 hasAuthorship W2059790042A5077165179 @default.
• W2059790042 hasBestOaLocation W20597900421 @default.
• W2059790042 hasConcept C104317684 @default.
• W2059790042 hasConcept C127716648 @default.
• W2059790042 hasConcept C128240485 @default.
• W2059790042 hasConcept C145103041 @default.
• W2059790042 hasConcept C145837895 @default.
• W2059790042 hasConcept C170493617 @default.
• W2059790042 hasConcept C2775958995 @default.
• W2059790042 hasConcept C2776133846 @default.
• W2059790042 hasConcept C2776637008 @default.
• W2059790042 hasConcept C2776878037 @default.
• W2059790042 hasConcept C2777994357 @default.
• W2059790042 hasConcept C2779018604 @default.
• W2059790042 hasConcept C54355233 @default.
• W2059790042 hasConcept C62478195 @default.
• W2059790042 hasConcept C64863464 @default.
• W2059790042 hasConcept C86803240 @default.
• W2059790042 hasConcept C87073359 @default.
• W2059790042 hasConcept C88498014 @default.
• W2059790042 hasConcept C95444343 @default.
• W2059790042 hasConceptScore W2059790042C104317684 @default.
• W2059790042 hasConceptScore W2059790042C127716648 @default.
• W2059790042 hasConceptScore W2059790042C128240485 @default.
• W2059790042 hasConceptScore W2059790042C145103041 @default.
• W2059790042 hasConceptScore W2059790042C145837895 @default.
• W2059790042 hasConceptScore W2059790042C170493617 @default.
• W2059790042 hasConceptScore W2059790042C2775958995 @default.
• W2059790042 hasConceptScore W2059790042C2776133846 @default.
• W2059790042 hasConceptScore W2059790042C2776637008 @default.
• W2059790042 hasConceptScore W2059790042C2776878037 @default.
• W2059790042 hasConceptScore W2059790042C2777994357 @default.
• W2059790042 hasConceptScore W2059790042C2779018604 @default.
• W2059790042 hasConceptScore W2059790042C54355233 @default.
• W2059790042 hasConceptScore W2059790042C62478195 @default.
• W2059790042 hasConceptScore W2059790042C64863464 @default.

• next