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- W2059790600 abstract "In the present study, genetic changes in the polymerase gene were analyzed in seven patients after 4 weeks of short-term lamivudine therapy, and those in the entire HBV genome were also investigated in one incomplete responder during 24 weeks of long-term therapy. During short-term therapy, serum HBV-DNA levels decreased rapidly in all seven patients, but were still detectable in four patients at the end of the therapy. In three of these four patients, one to five amino acid substitutions were observed in the polymerase gene other than YMDD. In contrast, no genetic changes were found in three patients who became negative for HBV-DNA by the end of therapy. In one incomplete responder to long-term therapy, eight amino acid substitutions were detected during lamivudine therapy throughout the entire HBV genome including the X, surface and core genes as well as the polymerase gene but not YMDD. In conclusion, HBV mutations other than YMDD motif or even outside the reverse transcriptase gene were found after lamivudine therapy, suggesting their contribution to reduced sensitivity to lamivudine. YMDD mutations seem to be rare during short-term therapy in immunocompetent chronic hepatitis B patients." @default.
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- W2059790600 date "1999-07-01" @default.
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- W2059790600 title "Hepatitis B virus mutations associated with lamivudine therapy in patients with chronic hepatitis B" @default.
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