Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059790885> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2059790885 endingPage "155" @default.
- W2059790885 startingPage "150" @default.
- W2059790885 abstract "Human alcohol dehydrogenases (ADHs) play important roles in metabolizing alcohol, and several lines of evidence suggest that variations in ADH genes affect the risk for alcoholism. Differences in regulatory sequences could affect the expression of ADH genes and thereby modify the risk for alcoholism. To explore this idea, we sequenced regulatory regions upstream of ADH1C and identified 13 polymorphisms, including one 66-base pair (bp) insertion/deletion (in/del), one 5-bp variation, and 11 single nucleotide polymorphisms (SNPs), eight of which were newly identified. We examined the effects of naturally occurring haplotypes on gene expression. The 66-bp in/del alone did not change promoter activity, but when it was combined with three other SNP alleles, a twofold difference in transcription activity was observed in transient transfection assays in H4IIE-C3 cells. These data imply that there are interactions among polymorphisms in the cis-acting elements, and highlight the importance of studying regulatory polymorphisms within the context of their naturally occurring haplotypes. We also demonstrated tissue specificity in cis-acting elements by comparing gene expression in H4IIE-C3 and HeLa cells." @default.
- W2059790885 created "2016-06-24" @default.
- W2059790885 creator A5050103348 @default.
- W2059790885 creator A5050209813 @default.
- W2059790885 creator A5054101735 @default.
- W2059790885 date "2005-01-10" @default.
- W2059790885 modified "2023-09-25" @default.
- W2059790885 title "Natural haplotypes in the regulatory sequences affect human alcohol dehydrogenase 1C ( <i>ADH1C</i> ) gene expression" @default.
- W2059790885 cites W1548395897 @default.
- W2059790885 cites W1972894823 @default.
- W2059790885 cites W1988118050 @default.
- W2059790885 cites W1989930057 @default.
- W2059790885 cites W2000125570 @default.
- W2059790885 cites W2000753436 @default.
- W2059790885 cites W2059723753 @default.
- W2059790885 cites W2068370446 @default.
- W2059790885 cites W2072321912 @default.
- W2059790885 cites W2082595364 @default.
- W2059790885 cites W2122821473 @default.
- W2059790885 cites W2148911584 @default.
- W2059790885 cites W2153127576 @default.
- W2059790885 cites W2156059881 @default.
- W2059790885 cites W2175278878 @default.
- W2059790885 cites W4236181026 @default.
- W2059790885 cites W4242643049 @default.
- W2059790885 cites W4375934515 @default.
- W2059790885 doi "https://doi.org/10.1002/humu.20127" @default.
- W2059790885 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15643610" @default.
- W2059790885 hasPublicationYear "2005" @default.
- W2059790885 type Work @default.
- W2059790885 sameAs 2059790885 @default.
- W2059790885 citedByCount "20" @default.
- W2059790885 countsByYear W20597908852012 @default.
- W2059790885 countsByYear W20597908852013 @default.
- W2059790885 countsByYear W20597908852017 @default.
- W2059790885 countsByYear W20597908852018 @default.
- W2059790885 countsByYear W20597908852019 @default.
- W2059790885 countsByYear W20597908852023 @default.
- W2059790885 crossrefType "journal-article" @default.
- W2059790885 hasAuthorship W2059790885A5050103348 @default.
- W2059790885 hasAuthorship W2059790885A5050209813 @default.
- W2059790885 hasAuthorship W2059790885A5054101735 @default.
- W2059790885 hasBestOaLocation W20597908851 @default.
- W2059790885 hasConcept C101762097 @default.
- W2059790885 hasConcept C104317684 @default.
- W2059790885 hasConcept C135763542 @default.
- W2059790885 hasConcept C139275648 @default.
- W2059790885 hasConcept C150194340 @default.
- W2059790885 hasConcept C153209595 @default.
- W2059790885 hasConcept C165864922 @default.
- W2059790885 hasConcept C180754005 @default.
- W2059790885 hasConcept C197754878 @default.
- W2059790885 hasConcept C21592294 @default.
- W2059790885 hasConcept C2777344606 @default.
- W2059790885 hasConcept C2781066024 @default.
- W2059790885 hasConcept C54355233 @default.
- W2059790885 hasConcept C55493867 @default.
- W2059790885 hasConcept C86339819 @default.
- W2059790885 hasConcept C86803240 @default.
- W2059790885 hasConceptScore W2059790885C101762097 @default.
- W2059790885 hasConceptScore W2059790885C104317684 @default.
- W2059790885 hasConceptScore W2059790885C135763542 @default.
- W2059790885 hasConceptScore W2059790885C139275648 @default.
- W2059790885 hasConceptScore W2059790885C150194340 @default.
- W2059790885 hasConceptScore W2059790885C153209595 @default.
- W2059790885 hasConceptScore W2059790885C165864922 @default.
- W2059790885 hasConceptScore W2059790885C180754005 @default.
- W2059790885 hasConceptScore W2059790885C197754878 @default.
- W2059790885 hasConceptScore W2059790885C21592294 @default.
- W2059790885 hasConceptScore W2059790885C2777344606 @default.
- W2059790885 hasConceptScore W2059790885C2781066024 @default.
- W2059790885 hasConceptScore W2059790885C54355233 @default.
- W2059790885 hasConceptScore W2059790885C55493867 @default.
- W2059790885 hasConceptScore W2059790885C86339819 @default.
- W2059790885 hasConceptScore W2059790885C86803240 @default.
- W2059790885 hasFunder F4320337330 @default.
- W2059790885 hasIssue "2" @default.
- W2059790885 hasLocation W20597908851 @default.
- W2059790885 hasLocation W20597908852 @default.
- W2059790885 hasOpenAccess W2059790885 @default.
- W2059790885 hasPrimaryLocation W20597908851 @default.
- W2059790885 hasRelatedWork W1541417441 @default.
- W2059790885 hasRelatedWork W1901150897 @default.
- W2059790885 hasRelatedWork W1966708416 @default.
- W2059790885 hasRelatedWork W1989311797 @default.
- W2059790885 hasRelatedWork W2021538970 @default.
- W2059790885 hasRelatedWork W2071146638 @default.
- W2059790885 hasRelatedWork W2072704524 @default.
- W2059790885 hasRelatedWork W2327017833 @default.
- W2059790885 hasRelatedWork W2360977025 @default.
- W2059790885 hasRelatedWork W860817473 @default.
- W2059790885 hasVolume "25" @default.
- W2059790885 isParatext "false" @default.
- W2059790885 isRetracted "false" @default.
- W2059790885 magId "2059790885" @default.
- W2059790885 workType "article" @default.