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- W205979460 startingPage "263" @default.
- W205979460 abstract "In recent years a great number of studies have been carried out that apply antisense oligonucleotide technology to investigate neurobiological systems (for recent reviews, see Weiss et al. 1996, 1997a,b; Zon 1995). The antisense approach has been particularly useful in characterizing the pharmacological properties and biological functions of receptors for neurotransmitters. This is due to the rapid discovery of the molecular structure of new subtypes of neurotransmitter receptors, the pharmacological and biological properties of which remain largely unknown. Antisense compounds, by hybridizing specifically to the nucleic acids encoding the different receptor subtypes, have provided a highly selective means to reduce the expression, and thereby the levels, of individual receptors, an effect that is not attainable with traditional pharmacological antagonists. In addition to providing a highly selective means to study various neurobiological events, antisense compounds have the potential to be used as therapeutic agents in the management of neuropsychiatric and neurodegenerative disorders. An antisense strategy to reduce the function of neuroreceptors might have a further distinct advantage over traditional pharmacological antagonists in that antisense agents, unlike the conventional pharmacological antagonists, might not induce the upregulation of the very receptors they are intended to inhibit (Burt et al. 1977; Hyttel 1986; Rogue et al. 1991)." @default.
- W205979460 created "2016-06-24" @default.
- W205979460 creator A5009479458 @default.
- W205979460 creator A5018377073 @default.
- W205979460 date "1998-01-01" @default.
- W205979460 modified "2023-09-27" @default.
- W205979460 title "Pharmacological Inhibition of Dopaminergic and Other Neurotransmitter Receptors Using Antisense Oligodeoxynucleotides" @default.
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