Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059798638> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2059798638 endingPage "150" @default.
- W2059798638 startingPage "150" @default.
- W2059798638 abstract "A major cause of mortality after spinal cord injury is respiratory failure. In normal rats, acute intermittent hypoxia (AIH) induces respiratory motor plasticity, expressed as diaphragm (Dia) and second external intercostal (T2 EIC) long-term facilitation (LTF). Dia (not T2 EIC) LTF is enhanced by systemic adenosine 2A (A2A) receptor inhibition in normal rats. We investigated the respective contributions of Dia and T2 EIC to daily AIH-induced functional recovery of breathing capacity with/without A2A receptor antagonist (KW6002, i.p.) following C2 hemisection (C2HS). Rats received daily AIH (dAIH: 10, 5-min episodes, 10.5% O2; 5-min normoxic intervals; 7 successive days beginning 7 days post-C2HS) or daily normoxia (dNx) with/without KW6002, followed by weekly (reminder) presentations for 8 weeks. Ventilation and EMGs from bilateral diaphragm and T2 EIC muscles were measured with room air breathing (21% O2) and maximum chemoreceptor stimulation (MCS: 7% CO2, 10.5% O2). dAIH increased tidal volume (VT) in C2HS rats breathing room air (dAIH + vehicle: 0.47 ± 0.02, dNx + vehicle: 0.40 ± 0.01 ml/100 g; p < 0.05) and MCS (dAIH + vehicle: 0.83 ± 0.01, dNx + vehicle: 0.73 ± 0.01 ml/100 g; p < 0.001); KW6002 had no significant effect. dAIH enhanced contralateral (uninjured) diaphragm EMG activity, an effect attenuated by KW6002, during room air breathing and MCS (p < 0.05). Although dAIH enhanced contralateral T2 EIC EMG activity during room air breathing, KW6002 had no effect. dAIH had no statistically significant effects on diaphragm or T2 EIC EMG activity ipsilateral to injury. Thus, two weeks post-C2HS: 1) dAIH enhances breathing capacity by effects on contralateral diaphragm and T2 EIC activity; and 2) dAIH-induced recovery is A2A dependent in diaphragm, but not T2 EIC. Daily AIH may be a useful in promoting functional recovery of breathing capacity after cervical spinal injury, but A2A receptor antagonists (e.g. caffeine) may undermine its effectiveness shortly after injury." @default.
- W2059798638 created "2016-06-24" @default.
- W2059798638 creator A5044153437 @default.
- W2059798638 creator A5082085098 @default.
- W2059798638 date "2010-07-01" @default.
- W2059798638 modified "2023-09-23" @default.
- W2059798638 title "Studying empathy as an interactional three-part sequence" @default.
- W2059798638 cites W1963641458 @default.
- W2059798638 cites W1982927468 @default.
- W2059798638 cites W1993232267 @default.
- W2059798638 cites W2001193333 @default.
- W2059798638 cites W2018561154 @default.
- W2059798638 cites W2046347080 @default.
- W2059798638 cites W2053829140 @default.
- W2059798638 cites W2101148391 @default.
- W2059798638 cites W2171879071 @default.
- W2059798638 cites W4244003512 @default.
- W2059798638 cites W4375277982 @default.
- W2059798638 doi "https://doi.org/10.1016/j.pec.2009.05.007" @default.
- W2059798638 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19553060" @default.
- W2059798638 hasPublicationYear "2010" @default.
- W2059798638 type Work @default.
- W2059798638 sameAs 2059798638 @default.
- W2059798638 citedByCount "4" @default.
- W2059798638 countsByYear W20597986382015 @default.
- W2059798638 countsByYear W20597986382016 @default.
- W2059798638 countsByYear W20597986382020 @default.
- W2059798638 countsByYear W20597986382022 @default.
- W2059798638 crossrefType "journal-article" @default.
- W2059798638 hasAuthorship W2059798638A5044153437 @default.
- W2059798638 hasAuthorship W2059798638A5082085098 @default.
- W2059798638 hasConcept C121332964 @default.
- W2059798638 hasConcept C126322002 @default.
- W2059798638 hasConcept C127413603 @default.
- W2059798638 hasConcept C1337776 @default.
- W2059798638 hasConcept C157138929 @default.
- W2059798638 hasConcept C15744967 @default.
- W2059798638 hasConcept C164292776 @default.
- W2059798638 hasConcept C164705383 @default.
- W2059798638 hasConcept C169760540 @default.
- W2059798638 hasConcept C170493617 @default.
- W2059798638 hasConcept C200457457 @default.
- W2059798638 hasConcept C24890656 @default.
- W2059798638 hasConcept C2776885963 @default.
- W2059798638 hasConcept C2777257755 @default.
- W2059798638 hasConcept C39300077 @default.
- W2059798638 hasConcept C42219234 @default.
- W2059798638 hasConcept C534529494 @default.
- W2059798638 hasConcept C71924100 @default.
- W2059798638 hasConcept C78519656 @default.
- W2059798638 hasConceptScore W2059798638C121332964 @default.
- W2059798638 hasConceptScore W2059798638C126322002 @default.
- W2059798638 hasConceptScore W2059798638C127413603 @default.
- W2059798638 hasConceptScore W2059798638C1337776 @default.
- W2059798638 hasConceptScore W2059798638C157138929 @default.
- W2059798638 hasConceptScore W2059798638C15744967 @default.
- W2059798638 hasConceptScore W2059798638C164292776 @default.
- W2059798638 hasConceptScore W2059798638C164705383 @default.
- W2059798638 hasConceptScore W2059798638C169760540 @default.
- W2059798638 hasConceptScore W2059798638C170493617 @default.
- W2059798638 hasConceptScore W2059798638C200457457 @default.
- W2059798638 hasConceptScore W2059798638C24890656 @default.
- W2059798638 hasConceptScore W2059798638C2776885963 @default.
- W2059798638 hasConceptScore W2059798638C2777257755 @default.
- W2059798638 hasConceptScore W2059798638C39300077 @default.
- W2059798638 hasConceptScore W2059798638C42219234 @default.
- W2059798638 hasConceptScore W2059798638C534529494 @default.
- W2059798638 hasConceptScore W2059798638C71924100 @default.
- W2059798638 hasConceptScore W2059798638C78519656 @default.
- W2059798638 hasIssue "1" @default.
- W2059798638 hasLocation W20597986381 @default.
- W2059798638 hasLocation W20597986382 @default.
- W2059798638 hasOpenAccess W2059798638 @default.
- W2059798638 hasPrimaryLocation W20597986381 @default.
- W2059798638 hasRelatedWork W1972994875 @default.
- W2059798638 hasRelatedWork W1986413657 @default.
- W2059798638 hasRelatedWork W2013013378 @default.
- W2059798638 hasRelatedWork W2017707480 @default.
- W2059798638 hasRelatedWork W2056587366 @default.
- W2059798638 hasRelatedWork W2134703833 @default.
- W2059798638 hasRelatedWork W2395283192 @default.
- W2059798638 hasRelatedWork W3032736716 @default.
- W2059798638 hasRelatedWork W4245934305 @default.
- W2059798638 hasRelatedWork W86189361 @default.
- W2059798638 hasVolume "80" @default.
- W2059798638 isParatext "false" @default.
- W2059798638 isRetracted "false" @default.
- W2059798638 magId "2059798638" @default.
- W2059798638 workType "article" @default.