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- W2059802227 abstract "W it hout any significant adverse effects o n both mother and ch ild , hi gh-d ose IgG infusion effectivel y increased pla te le t count in a pregn a nt woman with idiopa t h ic throm bocytopenic purpura , wh o had fail e d to respo nd to the standard dose of p rednisolone. T he mechanisms by which IgG works st ill remain uncla rified. H owever , th is thera p y is superior to pla telet transfu sio n in several respects , suc h as (I) it is long ac ting, (2) there is no production of antip latelet antibody, (3) the re is no r isk of viral he pa tit is , and (4) it is easi ly avai lable . Since S-sulfonized IgG has an intact Fc uni t, it may be likel y that IgG given to the mother reaches the fe ta l circula tio n by ac tive tr ans port and blocks p latelet destruction in the fetu s as well. Indeed , the pl a tele t co u n t o f the neonate in t his cas e did no t show a progressive decrease a fter birt h . H o we ver, of inte rest, the Ig G concentration in the cord blood wa s only a third as much as tha t of the mother, and th e possibilit y that IgG given to the mother exerts its act ivity in the feta l circula tio n wa s not co n firmed in thi s report." @default.
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- W2059802227 date "1984-01-01" @default.
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- W2059802227 title "An unusual case of fetal distress" @default.
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- W2059802227 doi "https://doi.org/10.1016/s0002-9378(84)80180-5" @default.
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