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• W2059831345 abstract "Annals of the New York Academy of SciencesVolume 226, Issue 1 p. 333-340 INTERACTION OF DRUGS WITH THYROID HORMONE BINDING SITES* Jack H. Oppenheimer, Jack H. Oppenheimer Division of Endocrinology, Department of Medicine Montefiore Hospital and Medical Center and the Albert Einstein College of Medicine Bronx, New York 10467Search for more papers by this author Jack H. Oppenheimer, Jack H. Oppenheimer Division of Endocrinology, Department of Medicine Montefiore Hospital and Medical Center and the Albert Einstein College of Medicine Bronx, New York 10467Search for more papers by this author First published: November 1973 https://doi.org/10.1111/j.1749-6632.1973.tb20494.xCitations: 4 * Supported by National Institutes of Health Grant AM 15421-13. AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL References 1 Surks, M. I., A. R. Schadlow, J. M. Stock & J. H. Oppenheimer 1973. Determination of iodothyronine absorption and conversion of l-thyroxine (T4) to l-triiodothyronine (T3) using turnover rate techniques. J. Clin. Invest. 52: 805– 811. 2 Bowers, C. Y., A. V. Schally, F. Enzmann, J. Boler & K. Fulkers 1970. Porcine thyrotropin releasing hormone is (pyro) Glu-His-Pro (NH2). Endocrinology 86: 1143– 1153. 3 Guillemin, R. 1964. Hypothalamic factors releasing pituitary hormones. Recent Progr. Hormone Res. 20: 89– 121. 4 Braverman, L. E., S. H. Ingbar & K. Sterling 1970. Conversion of thyroxine (T4) to triiodothyronine (T3) in athyreotic human subjects. J. Clin. Invest. 49: 855– 864. 5 Oppenheimer, J. H., D. Koerner, H. L. Schwartz & M. I. Surks 1972. Specific nuclear triiodothyronine binding sites in rat liver and kidney. J. Clin. Endocrinol. Metab. 35: 330– 333. 6 Oppenheimer, J. H. 1968. Role of plasma proteins in the binding, distribution and metabolism of the thyroid hormones. N. Engl. J. Med. 278: 1153– 1162. 7 Robbins, J. & J. E. Rall 1960. Proteins associated with thyroid hormones. Physiol. Rev. 40: 415– 489. 8 Giorgio, N. A. & M. Tabachnick 1968. Thyroxine-protein interactions. V. Isolation and characterization of a thyroxine-binding globulin from human plasma. J. Biol. Chem. 243: 2247– 2259. 9 Marshall, J. S. & J. Pensky 1969. Studies on thyroxine-binding globulin (TBG). I. Purification of TBG and immunologic studies on the relationship between TBG from normal persons and those with TBG “deficiency.” J. Clin. Invest. 48: 508– 515. 10 Sterling, K., S. Hamada, Y. Takenura, M. A. Brenner, E. S. Newman & M. Imada 1970. Preparation and properties of thyroxine-binding alpha globulin. J. Clin. Invest. 50: 1758– 1771. 11 Oppenheimer, J. H., M. I. Surks & R. Squef 1965. Isolation and characterization of human thyroxine-binding globulin. J. Biol. Chem. 240: 173– 180. 12 Raz, A. & D. S. Goodman 1969. The interaction of thyroxine with human plasma prealbumin and with the prealbumin-retinol-binding protein complex. J. Biol. Chem. 244: 3230– 3237. 13 Green, A. M., I. S. Marshall, I. Pensky & J. B. Stanburg 1972. Thyroxine-binding globulin: characterization of the binding site with a fluorescent dye as a probe. Science 175: 1378– 1380. 14 Woeber, K. A. 1971. Tests of hormonal transport. In The Thyroid. S. C. Weiner & S. H. Ingbar, Eds. 3rd edit. Chap. 19: 256– 266. Harper & Row. New York , N.Y . 15 Lrsen, P. R. 1972. Salicylate-induced increases in free triiodothyronine in human serum. Evidence of inhibition of triiodothyronine binding to thyroxine-binding globulin and thyroxine-binding albumin. J. Clin. Invest. 51: 1125– 1134. 16 Schatz, D. L., R. H. Sheppard, G. Steiner, C. S. Chondarlapaty & G. A. De Veber 1969. Influence of heparin on serum free thyroxine. J. Clin. Endocrinol. Metab. 29: 1015– 1022. 17 Schwartz, H. L., A. R. Schadlow, D. Faierman, M. I. Surks & J. H. Oppenheimer 1973. Heparin administration appears to decrease cellular binding of thyroxine. J. Clin. Endocrinol. Metab. 36: 598– 600. 18 Oppenheimer, J. H., M. I. Surks & H. L. Schwartz 1969. The metabolic significance of exchangeable cellular thyroxine. Recent Progr. Hormone Res. 25: 381– 422. 19 Mendoza, D. M., E. V. Flock, C. A. Owen, Jr. & J. Paris 1966. Effect of diphenylhydantoin on metabolism of l-thyroxine-131I in rat. Endocrinology 79: 106– 118. 20 Larsen, P. R., A. J. Atkinson, H. N. Willman & R. E. Goldsmith 1970. The effect of diphenylhydantoin on thyroxine metabolism in man. J. Clin. Invest. 49: 1266– 1279. 21 Van Arsdel, P. P. Jr. & R. H. Williams 1956. Effect of propylthiouracil on degradation of I131-labeled thyroxine and triiodothyronine. Amer. J. Physiol. 186: 440– 444. 22 Jones, S. L. & L. Van Middlesworth 1960. Normal I131-l-thyroxine metabolism in the presence of potassium perchlorate and interrupted by propylthiouracil. Endocrinology 67: 855– 861. 23 Oppenheimer, J. H., H. C. Shapiro, H. L. Schwartz & M. I. Surks 1971. Dissociation between thyroxine metabolism and hormonal action in phenobarbital-treated rats. Endocrinology 88: 115– 119. 24 Cavalieri, R. P. & C. E. Becker 1971. Effects of phenobarbital on thyroid hormone kinetics in Graves' Disease. Program of the American Thyroid Association. 47th Annual Meeting, Birmingham , Alabama. : 15. 25 Oppenheimer, J. H., H. L. Schwartz & M. I. Surks 1972. Propylthiouracil inhibits the conversion of l-thyroxine to l-triiodothyronine: an explanation of the antithyroxine effects of propylthiouracil and evidence supporting the concept that triiodothyronine is the active thyroid hormone. J. Clin. Invest. 51: 2493– 2497. 26 Tata, J. R. & C. C. Widnell 1966. Ribonucleic acid synthesis during the early action of thyroid hormones, Biochem. J. 98: 604– 620. Citing Literature Volume226, Issue1Drug‐Protein BindingNovember 1973Pages 333-340 ReferencesRelatedInformation" @default.
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