FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059833049> ?p ?o ?g. }

• W2059833049 endingPage "6723" @default.
• W2059833049 startingPage "6709" @default.
• W2059833049 abstract "Novel pro-apoptotic, homodimeric and heterodimeric Smac mimetics/IAPs inhibitors connected through head-head (8), tail-tail (9) or head-tail linkers (10), were biologically and structurally characterized. In vitro characterization (binding to BIR3 and linker-BIR2-BIR3 domains from XIAP and cIAP1, cytotoxicity assays) identified early leads from each dimer family. Computational models and structural studies (crystallography, NMR, gel filtration) partially rationalized the observed properties for each dimer class. Tail-tail dimer 9a was shown to be active in a breast and in an ovary tumor model, highlighting the potential of dimeric Smac mimetics/IAP inhibitors based on the N-AVPI-like 4-substituted 1-aza-2-oxobicyclo[5.3.0]decane scaffold as potential antineoplastic agents." @default.
• W2059833049 created "2016-06-24" @default.
• W2059833049 creator A5001051661 @default.
• W2059833049 creator A5006647206 @default.
• W2059833049 creator A5012393605 @default.
• W2059833049 creator A5015458706 @default.
• W2059833049 creator A5025995605 @default.
• W2059833049 creator A5028098035 @default.
• W2059833049 creator A5031299292 @default.
• W2059833049 creator A5033939122 @default.
• W2059833049 creator A5034854833 @default.
• W2059833049 creator A5041540668 @default.
• W2059833049 creator A5044399312 @default.
• W2059833049 creator A5045604495 @default.
• W2059833049 creator A5048820442 @default.
• W2059833049 creator A5049565862 @default.
• W2059833049 creator A5056175990 @default.
• W2059833049 creator A5066081837 @default.
• W2059833049 creator A5069152410 @default.
• W2059833049 creator A5070605941 @default.
• W2059833049 creator A5070848001 @default.
• W2059833049 creator A5075852039 @default.
• W2059833049 creator A5080190860 @default.
• W2059833049 date "2012-11-01" @default.
• W2059833049 modified "2023-10-13" @default.
• W2059833049 title "Dimeric Smac mimetics/IAP inhibitors as in vivo-active pro-apoptotic agents. Part II: Structural and biological characterization" @default.
• W2059833049 cites W1971314986 @default.
• W2059833049 cites W1972483602 @default.
• W2059833049 cites W1982126789 @default.
• W2059833049 cites W1986320887 @default.
• W2059833049 cites W1989726571 @default.
• W2059833049 cites W1996066245 @default.
• W2059833049 cites W2000436482 @default.
• W2059833049 cites W2003926188 @default.
• W2059833049 cites W2014569891 @default.
• W2059833049 cites W2035266068 @default.
• W2059833049 cites W2039597975 @default.
• W2059833049 cites W2040370168 @default.
• W2059833049 cites W2052064497 @default.
• W2059833049 cites W2061151008 @default.
• W2059833049 cites W2063685408 @default.
• W2059833049 cites W2065796973 @default.
• W2059833049 cites W2065818103 @default.
• W2059833049 cites W2067174909 @default.
• W2059833049 cites W2069766232 @default.
• W2059833049 cites W2080207536 @default.
• W2059833049 cites W2082807544 @default.
• W2059833049 cites W2095453782 @default.
• W2059833049 cites W2159307624 @default.
• W2059833049 cites W2165737898 @default.
• W2059833049 cites W2323464985 @default.
• W2059833049 doi "https://doi.org/10.1016/j.bmc.2012.09.041" @default.
• W2059833049 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23062821" @default.
• W2059833049 hasPublicationYear "2012" @default.
• W2059833049 type Work @default.
• W2059833049 sameAs 2059833049 @default.
• W2059833049 citedByCount "28" @default.
• W2059833049 countsByYear W20598330492012 @default.
• W2059833049 countsByYear W20598330492013 @default.
• W2059833049 countsByYear W20598330492014 @default.
• W2059833049 countsByYear W20598330492015 @default.
• W2059833049 countsByYear W20598330492016 @default.
• W2059833049 countsByYear W20598330492017 @default.
• W2059833049 countsByYear W20598330492018 @default.
• W2059833049 countsByYear W20598330492019 @default.
• W2059833049 countsByYear W20598330492020 @default.
• W2059833049 countsByYear W20598330492021 @default.
• W2059833049 countsByYear W20598330492023 @default.
• W2059833049 crossrefType "journal-article" @default.
• W2059833049 hasAuthorship W2059833049A5001051661 @default.
• W2059833049 hasAuthorship W2059833049A5006647206 @default.
• W2059833049 hasAuthorship W2059833049A5012393605 @default.
• W2059833049 hasAuthorship W2059833049A5015458706 @default.
• W2059833049 hasAuthorship W2059833049A5025995605 @default.
• W2059833049 hasAuthorship W2059833049A5028098035 @default.
• W2059833049 hasAuthorship W2059833049A5031299292 @default.
• W2059833049 hasAuthorship W2059833049A5033939122 @default.
• W2059833049 hasAuthorship W2059833049A5034854833 @default.
• W2059833049 hasAuthorship W2059833049A5041540668 @default.
• W2059833049 hasAuthorship W2059833049A5044399312 @default.
• W2059833049 hasAuthorship W2059833049A5045604495 @default.
• W2059833049 hasAuthorship W2059833049A5048820442 @default.
• W2059833049 hasAuthorship W2059833049A5049565862 @default.
• W2059833049 hasAuthorship W2059833049A5056175990 @default.
• W2059833049 hasAuthorship W2059833049A5066081837 @default.
• W2059833049 hasAuthorship W2059833049A5069152410 @default.
• W2059833049 hasAuthorship W2059833049A5070605941 @default.
• W2059833049 hasAuthorship W2059833049A5070848001 @default.
• W2059833049 hasAuthorship W2059833049A5075852039 @default.
• W2059833049 hasAuthorship W2059833049A5080190860 @default.
• W2059833049 hasConcept C109316439 @default.
• W2059833049 hasConcept C111919701 @default.
• W2059833049 hasConcept C12554922 @default.
• W2059833049 hasConcept C150903083 @default.
• W2059833049 hasConcept C178790620 @default.
• W2059833049 hasConcept C185592680 @default.
• W2059833049 hasConcept C190283241 @default.
• W2059833049 hasConcept C202751555 @default.

• next