FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059836653> ?p ?o ?g. }

• W2059836653 endingPage "163" @default.
• W2059836653 startingPage "156" @default.
• W2059836653 abstract "Glycine-proline-glutamate (GPE) is the N-terminal tripeptide of insulin-like growth factor-1 and has been shown to be neuroprotective following ischemia-induced brain injury. The pharmacokinetics of GPE were studied in adult rats since GPE is a candidate for use in neuroprotection therapies. To measure plasma concentrations of GPE a novel radioimmunoassay was developed whereby GPE was initially derivatized with Bolton and Hunter reagent before use in a standard homologous assay against the Bolton and Hunter iodinated form. The derivatized GPE radioimmunoassay showed a 83% recovery of unlabeled GPE and complete parallel displacement with rat plasma. The simplicity and speed of the assay described here indicate an exciting new use for a previously described technology. The pharmacokinetic studies were conducted in adult rats using a single bolus intravenous injection of GPE at 30 or 100 mg/kg and showed that GPE was rapidly cleared from the circulation. In addition, evidence of the route of the metabolic degradation of GPE is presented. The findings presented here are the first description of the pharmacokinetics of GPE and suggest that, because of its very short half-life in plasma, continuous intravenous infusion of GPE may be the preferred route of administration for use in future neuroprotection therapies." @default.
• W2059836653 created "2016-06-24" @default.
• W2059836653 creator A5007924062 @default.
• W2059836653 creator A5008183197 @default.
• W2059836653 creator A5010659130 @default.
• W2059836653 creator A5015985724 @default.
• W2059836653 creator A5039318524 @default.
• W2059836653 creator A5058979039 @default.
• W2059836653 creator A5062546503 @default.
• W2059836653 creator A5080312121 @default.
• W2059836653 date "2003-12-01" @default.
• W2059836653 modified "2023-10-12" @default.
• W2059836653 title "Pharmacokinetics of glycine–proline–glutamate, the N-terminal tripeptide of insulin-like growth factor-1, in rats" @default.
• W2059836653 cites W1515542254 @default.
• W2059836653 cites W1893651774 @default.
• W2059836653 cites W1976904171 @default.
• W2059836653 cites W1981819503 @default.
• W2059836653 cites W1984620374 @default.
• W2059836653 cites W1984891009 @default.
• W2059836653 cites W2006734329 @default.
• W2059836653 cites W2011830245 @default.
• W2059836653 cites W2019061543 @default.
• W2059836653 cites W2030495753 @default.
• W2059836653 cites W2032223545 @default.
• W2059836653 cites W2033785962 @default.
• W2059836653 cites W2050250315 @default.
• W2059836653 cites W2056439258 @default.
• W2059836653 cites W2058949189 @default.
• W2059836653 cites W2063901263 @default.
• W2059836653 cites W2063981108 @default.
• W2059836653 cites W2065054155 @default.
• W2059836653 cites W2066609648 @default.
• W2059836653 cites W2069335115 @default.
• W2059836653 cites W2071934406 @default.
• W2059836653 cites W2074170897 @default.
• W2059836653 cites W2082303357 @default.
• W2059836653 cites W2095211398 @default.
• W2059836653 cites W2171492397 @default.
• W2059836653 cites W2461910271 @default.
• W2059836653 cites W258376682 @default.
• W2059836653 cites W2912584308 @default.
• W2059836653 doi "https://doi.org/10.1016/j.ab.2003.08.032" @default.
• W2059836653 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14656520" @default.
• W2059836653 hasPublicationYear "2003" @default.
• W2059836653 type Work @default.
• W2059836653 sameAs 2059836653 @default.
• W2059836653 citedByCount "33" @default.
• W2059836653 countsByYear W20598366532012 @default.
• W2059836653 countsByYear W20598366532015 @default.
• W2059836653 countsByYear W20598366532016 @default.
• W2059836653 countsByYear W20598366532017 @default.
• W2059836653 countsByYear W20598366532018 @default.
• W2059836653 countsByYear W20598366532020 @default.
• W2059836653 countsByYear W20598366532021 @default.
• W2059836653 countsByYear W20598366532022 @default.
• W2059836653 countsByYear W20598366532023 @default.
• W2059836653 crossrefType "journal-article" @default.
• W2059836653 hasAuthorship W2059836653A5007924062 @default.
• W2059836653 hasAuthorship W2059836653A5008183197 @default.
• W2059836653 hasAuthorship W2059836653A5010659130 @default.
• W2059836653 hasAuthorship W2059836653A5015985724 @default.
• W2059836653 hasAuthorship W2059836653A5039318524 @default.
• W2059836653 hasAuthorship W2059836653A5058979039 @default.
• W2059836653 hasAuthorship W2059836653A5062546503 @default.
• W2059836653 hasAuthorship W2059836653A5080312121 @default.
• W2059836653 hasConcept C108215921 @default.
• W2059836653 hasConcept C112705442 @default.
• W2059836653 hasConcept C134018914 @default.
• W2059836653 hasConcept C167392928 @default.
• W2059836653 hasConcept C170493617 @default.
• W2059836653 hasConcept C176685330 @default.
• W2059836653 hasConcept C185592680 @default.
• W2059836653 hasConcept C25498285 @default.
• W2059836653 hasConcept C2777756961 @default.
• W2059836653 hasConcept C2779306644 @default.
• W2059836653 hasConcept C515207424 @default.
• W2059836653 hasConcept C55493867 @default.
• W2059836653 hasConcept C61174792 @default.
• W2059836653 hasConcept C71924100 @default.
• W2059836653 hasConcept C98274493 @default.
• W2059836653 hasConceptScore W2059836653C108215921 @default.
• W2059836653 hasConceptScore W2059836653C112705442 @default.
• W2059836653 hasConceptScore W2059836653C134018914 @default.
• W2059836653 hasConceptScore W2059836653C167392928 @default.
• W2059836653 hasConceptScore W2059836653C170493617 @default.
• W2059836653 hasConceptScore W2059836653C176685330 @default.
• W2059836653 hasConceptScore W2059836653C185592680 @default.
• W2059836653 hasConceptScore W2059836653C25498285 @default.
• W2059836653 hasConceptScore W2059836653C2777756961 @default.
• W2059836653 hasConceptScore W2059836653C2779306644 @default.
• W2059836653 hasConceptScore W2059836653C515207424 @default.
• W2059836653 hasConceptScore W2059836653C55493867 @default.
• W2059836653 hasConceptScore W2059836653C61174792 @default.
• W2059836653 hasConceptScore W2059836653C71924100 @default.
• W2059836653 hasConceptScore W2059836653C98274493 @default.
• W2059836653 hasIssue "2" @default.
• W2059836653 hasLocation W20598366531 @default.
• W2059836653 hasLocation W20598366532 @default.

• next