FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059842365> ?p ?o ?g. }

• W2059842365 endingPage "327" @default.
• W2059842365 startingPage "319" @default.
• W2059842365 abstract "The biochemical and molecular events correlated with neuronal injury and survival are not well understood. Previous studies have reported that following axotomy, neurons in the substantia nigra pars compacta (SNc) and the locus ceruleus (LC) exhibit a significant increase in tyrosine hydroxylase (TH) enzyme activity within 24-72 h (Brain Res., 144 (1978) 325-342; Brain Res., 92 (1975) 57-72). To investigate the potential contribution of TH gene induction to this increase a semi-quantitative immunocytochemical and in situ hybridization time course analysis was undertaken. Following axotomy, TH immunoreactivity increased in neurons of both the SNc and LC. In contrast, an increase in TH mRNA was only evident in neurons of the LC. As a possible mechanism for the observed alterations in TH gene expression, the levels of an immediate early gene, c-fos, were examined. C-fos mRNA and Fos protein were not expressed in either normal or axotomized neurons of the SNc. However, the constitutive expression in control LC neurons increased significantly following axotomy. These data demonstrate the differential response of two central catecholaminergic populations to axotomy and suggests a potential role for the immediate early gene, c-fos, in the post-injury reaction." @default.
• W2059842365 created "2016-06-24" @default.
• W2059842365 creator A5046381867 @default.
• W2059842365 creator A5047294941 @default.
• W2059842365 creator A5053410578 @default.
• W2059842365 creator A5068433317 @default.
• W2059842365 date "1993-03-01" @default.
• W2059842365 modified "2023-09-26" @default.
• W2059842365 title "Axotomy-induced differential gene induction in neurons of the locus ceruleus and substantia nigra" @default.
• W2059842365 cites W1965948714 @default.
• W2059842365 cites W1967457568 @default.
• W2059842365 cites W1967590869 @default.
• W2059842365 cites W1969949240 @default.
• W2059842365 cites W1971244903 @default.
• W2059842365 cites W1980524613 @default.
• W2059842365 cites W1993855542 @default.
• W2059842365 cites W1995062082 @default.
• W2059842365 cites W2001026574 @default.
• W2059842365 cites W2002287054 @default.
• W2059842365 cites W2003119451 @default.
• W2059842365 cites W2009874687 @default.
• W2059842365 cites W2027069212 @default.
• W2059842365 cites W2028318252 @default.
• W2059842365 cites W2034253186 @default.
• W2059842365 cites W2042458199 @default.
• W2059842365 cites W2042569804 @default.
• W2059842365 cites W2062024731 @default.
• W2059842365 cites W2069737416 @default.
• W2059842365 cites W2076117351 @default.
• W2059842365 cites W2078078440 @default.
• W2059842365 cites W2080125844 @default.
• W2059842365 cites W2085415388 @default.
• W2059842365 cites W2086483799 @default.
• W2059842365 cites W2091764874 @default.
• W2059842365 cites W2094930550 @default.
• W2059842365 cites W2094973947 @default.
• W2059842365 cites W2097555545 @default.
• W2059842365 cites W2115736681 @default.
• W2059842365 cites W2329876235 @default.
• W2059842365 doi "https://doi.org/10.1016/0169-328x(93)90017-j" @default.
• W2059842365 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8099702" @default.
• W2059842365 hasPublicationYear "1993" @default.
• W2059842365 type Work @default.
• W2059842365 sameAs 2059842365 @default.
• W2059842365 citedByCount "35" @default.
• W2059842365 countsByYear W20598423652013 @default.
• W2059842365 crossrefType "journal-article" @default.
• W2059842365 hasAuthorship W2059842365A5046381867 @default.
• W2059842365 hasAuthorship W2059842365A5047294941 @default.
• W2059842365 hasAuthorship W2059842365A5053410578 @default.
• W2059842365 hasAuthorship W2059842365A5068433317 @default.
• W2059842365 hasConcept C104317684 @default.
• W2059842365 hasConcept C126322002 @default.
• W2059842365 hasConcept C134018914 @default.
• W2059842365 hasConcept C137183658 @default.
• W2059842365 hasConcept C150194340 @default.
• W2059842365 hasConcept C159167319 @default.
• W2059842365 hasConcept C169760540 @default.
• W2059842365 hasConcept C2775894120 @default.
• W2059842365 hasConcept C2776773494 @default.
• W2059842365 hasConcept C2776824294 @default.
• W2059842365 hasConcept C2777186548 @default.
• W2059842365 hasConcept C2778468602 @default.
• W2059842365 hasConcept C2779555244 @default.
• W2059842365 hasConcept C2779683492 @default.
• W2059842365 hasConcept C2780938664 @default.
• W2059842365 hasConcept C2909480419 @default.
• W2059842365 hasConcept C513476851 @default.
• W2059842365 hasConcept C529278444 @default.
• W2059842365 hasConcept C54355233 @default.
• W2059842365 hasConcept C71924100 @default.
• W2059842365 hasConcept C81439078 @default.
• W2059842365 hasConcept C86803240 @default.
• W2059842365 hasConceptScore W2059842365C104317684 @default.
• W2059842365 hasConceptScore W2059842365C126322002 @default.
• W2059842365 hasConceptScore W2059842365C134018914 @default.
• W2059842365 hasConceptScore W2059842365C137183658 @default.
• W2059842365 hasConceptScore W2059842365C150194340 @default.
• W2059842365 hasConceptScore W2059842365C159167319 @default.
• W2059842365 hasConceptScore W2059842365C169760540 @default.
• W2059842365 hasConceptScore W2059842365C2775894120 @default.
• W2059842365 hasConceptScore W2059842365C2776773494 @default.
• W2059842365 hasConceptScore W2059842365C2776824294 @default.
• W2059842365 hasConceptScore W2059842365C2777186548 @default.
• W2059842365 hasConceptScore W2059842365C2778468602 @default.
• W2059842365 hasConceptScore W2059842365C2779555244 @default.
• W2059842365 hasConceptScore W2059842365C2779683492 @default.
• W2059842365 hasConceptScore W2059842365C2780938664 @default.
• W2059842365 hasConceptScore W2059842365C2909480419 @default.
• W2059842365 hasConceptScore W2059842365C513476851 @default.
• W2059842365 hasConceptScore W2059842365C529278444 @default.
• W2059842365 hasConceptScore W2059842365C54355233 @default.
• W2059842365 hasConceptScore W2059842365C71924100 @default.
• W2059842365 hasConceptScore W2059842365C81439078 @default.
• W2059842365 hasConceptScore W2059842365C86803240 @default.
• W2059842365 hasIssue "3-4" @default.
• W2059842365 hasLocation W20598423651 @default.
• W2059842365 hasLocation W20598423652 @default.

• next