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- W2059846596 abstract "A 25-year-old man was referred because of epigastric distress. Upper-GI barium contrast radiography demonstrated enlargement of the area gastrica (A). At gastroscopy, the mucosa in the antrum was edematous, and there were irregular-shaped erosions (B). These had sharp borders (C), as demonstrated by chromoscopy with indigo carmine dye. Culture for Helicobacter pylori infection was positive. Gastric biopsy specimens revealed viral inclusions characterized by a large nuclear inclusion and multiple punctate cytoplasmic inclusions, findings diagnostic of cytomegalovirus (CMV) infection (D; H&E, orig. mag. ×400). Biochemical tests of liver function were transiently elevated. A complete blood count was normal except that the differential white blood cell count included atypical lymphocytes (9%). The anti-Epstein-Barr virus antibody titer was within the normal range, but the serum IgM titer of anti-CMV antibody was 3.22 (normal: <0.8). An indirect immunofluorescence study of gastric biopsy specimens by using anti-CMV antibodies (Clones CCH2 + DDG9; DAKO, Ltd., Glostrup, Denmark) was a positive reaction in a scattered pattern, confirming the diagnosis of CMV-associated erosive gastritis. The patient was not treated with acid suppression agents or medication to eradicate the H pylori infection. At EGD, 3 months later, the erosions were healed, and the enlarged area gastrica had reverted to a normal appearance. The serum IgM anti-CMV titer had decreased to 0.93, while the IgG titer had increased from 18.5 to 30.2. The epigastric distress resolved. The pathogenesis of the CMV infection remains unknown. View Large Image Figure Viewer View Large Image Figure Viewer View Large Image Figure Viewer" @default.
- W2059846596 created "2016-06-24" @default.
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- W2059846596 date "2004-05-01" @default.
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- W2059846596 title "Cytomegalovirus-associated gastritis" @default.
- W2059846596 doi "https://doi.org/10.1016/s0016-5107(04)00163-4" @default.
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