Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059857576> ?p ?o ?g. }
- W2059857576 endingPage "2092" @default.
- W2059857576 startingPage "2083" @default.
- W2059857576 abstract "Death Receptor 5 (DR5) is a pro-apoptotic cell-surface receptor that is a potential therapeutic target in cancer. Despite the potency of DR5-targeting agents in preclinical models, the translation of these effects into the clinic remains disappointing. Herein, we report an alternative approach to exploiting DR5 tumor expression using antibody-targeted, chemotherapy-loaded nanoparticles. We describe the development of an optimized polymer-based nanotherapeutic incorporating both a functionalized polyethylene glycol (PEG) layer and targeting antibodies to limit premature phagocytic clearance whilst enabling targeting of DR5-expressing tumor cells. Using the HCT116 colorectal cancer model, we show that following binding to DR5, the nanoparticles activate caspase 8, enhancing the anti-tumor activity of the camptothecin payload both in vitro and in vivo. Importantly, the combination of nanoparticle-induced DR5 clustering with camptothecin delivery overcomes resistance to DR5-induced apoptosis caused by loss of BAX or overexpression of anti-apoptotic FLIP. This novel approach may improve the clinical activity of DR5-targeted therapeutics while increasing tumor-specific delivery of systemically toxic chemotherapeutics." @default.
- W2059857576 created "2016-06-24" @default.
- W2059857576 creator A5005209374 @default.
- W2059857576 creator A5017072034 @default.
- W2059857576 creator A5025156804 @default.
- W2059857576 creator A5026492423 @default.
- W2059857576 creator A5028474367 @default.
- W2059857576 creator A5044147012 @default.
- W2059857576 creator A5052131122 @default.
- W2059857576 creator A5056212256 @default.
- W2059857576 creator A5060371981 @default.
- W2059857576 creator A5063601436 @default.
- W2059857576 creator A5078841356 @default.
- W2059857576 date "2014-12-01" @default.
- W2059857576 modified "2023-10-15" @default.
- W2059857576 title "Efficient Drug Delivery and Induction of Apoptosis in Colorectal Tumors Using a Death Receptor 5-Targeted Nanomedicine" @default.
- W2059857576 cites W1527985047 @default.
- W2059857576 cites W1563016338 @default.
- W2059857576 cites W1605156779 @default.
- W2059857576 cites W1963527493 @default.
- W2059857576 cites W1965305046 @default.
- W2059857576 cites W1976792502 @default.
- W2059857576 cites W1977258127 @default.
- W2059857576 cites W1983914264 @default.
- W2059857576 cites W1990796256 @default.
- W2059857576 cites W1991388076 @default.
- W2059857576 cites W2007444742 @default.
- W2059857576 cites W2007718868 @default.
- W2059857576 cites W2013519249 @default.
- W2059857576 cites W2016516934 @default.
- W2059857576 cites W2023671240 @default.
- W2059857576 cites W2023820230 @default.
- W2059857576 cites W2028309691 @default.
- W2059857576 cites W2032654453 @default.
- W2059857576 cites W2032875036 @default.
- W2059857576 cites W2046723353 @default.
- W2059857576 cites W2047271635 @default.
- W2059857576 cites W2051223311 @default.
- W2059857576 cites W2056748936 @default.
- W2059857576 cites W2057053889 @default.
- W2059857576 cites W2059730843 @default.
- W2059857576 cites W2063251760 @default.
- W2059857576 cites W2065098249 @default.
- W2059857576 cites W2066694476 @default.
- W2059857576 cites W2070801001 @default.
- W2059857576 cites W2084607024 @default.
- W2059857576 cites W2087590198 @default.
- W2059857576 cites W2087877138 @default.
- W2059857576 cites W2088580558 @default.
- W2059857576 cites W2096443169 @default.
- W2059857576 cites W2103349496 @default.
- W2059857576 cites W2105491262 @default.
- W2059857576 cites W2116183504 @default.
- W2059857576 cites W2123123035 @default.
- W2059857576 cites W2126895514 @default.
- W2059857576 cites W2135486162 @default.
- W2059857576 cites W2146274229 @default.
- W2059857576 cites W2153232552 @default.
- W2059857576 cites W2156028272 @default.
- W2059857576 cites W2158018814 @default.
- W2059857576 cites W2319486658 @default.
- W2059857576 cites W2320870975 @default.
- W2059857576 cites W3147919323 @default.
- W2059857576 doi "https://doi.org/10.1038/mt.2014.137" @default.
- W2059857576 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4429693" @default.
- W2059857576 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25200008" @default.
- W2059857576 hasPublicationYear "2014" @default.
- W2059857576 type Work @default.
- W2059857576 sameAs 2059857576 @default.
- W2059857576 citedByCount "39" @default.
- W2059857576 countsByYear W20598575762015 @default.
- W2059857576 countsByYear W20598575762016 @default.
- W2059857576 countsByYear W20598575762017 @default.
- W2059857576 countsByYear W20598575762018 @default.
- W2059857576 countsByYear W20598575762019 @default.
- W2059857576 countsByYear W20598575762020 @default.
- W2059857576 countsByYear W20598575762021 @default.
- W2059857576 countsByYear W20598575762022 @default.
- W2059857576 countsByYear W20598575762023 @default.
- W2059857576 crossrefType "journal-article" @default.
- W2059857576 hasAuthorship W2059857576A5005209374 @default.
- W2059857576 hasAuthorship W2059857576A5017072034 @default.
- W2059857576 hasAuthorship W2059857576A5025156804 @default.
- W2059857576 hasAuthorship W2059857576A5026492423 @default.
- W2059857576 hasAuthorship W2059857576A5028474367 @default.
- W2059857576 hasAuthorship W2059857576A5044147012 @default.
- W2059857576 hasAuthorship W2059857576A5052131122 @default.
- W2059857576 hasAuthorship W2059857576A5056212256 @default.
- W2059857576 hasAuthorship W2059857576A5060371981 @default.
- W2059857576 hasAuthorship W2059857576A5063601436 @default.
- W2059857576 hasAuthorship W2059857576A5078841356 @default.
- W2059857576 hasBestOaLocation W20598575761 @default.
- W2059857576 hasConcept C121608353 @default.
- W2059857576 hasConcept C126322002 @default.
- W2059857576 hasConcept C15083742 @default.
- W2059857576 hasConcept C150903083 @default.
- W2059857576 hasConcept C155672457 @default.
- W2059857576 hasConcept C171250308 @default.