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- W2059868673 abstract "Ocimum selloi is an herbal species popularly used in Brazil as antispasmodic. Herein, we report the antispasmodic effect of O. selloi essential oil (OS) in segments of guinea-pig ileum. OS did not reduce the tonus of the ileum. In contrast, OS reduced the contraction induced by carbachol (100 μM), BaCl2 (0.03 M) and low- and high-K+ concentrations (25 and 60 mM, respectively). OS shifted the concentration–response curve for calcium to the right in a parallel manner. GC/MS analysis showed that OS consists mostly of methyl chavicol (97.57%). These results suggest that OS antispasmodic effect is mediated through calcium channel blockade. In addition, OS effect and mode of action could be accounted for methyl chavicol." @default.
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- W2059868673 date "2015-01-06" @default.
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- W2059868673 title "Antispasmodic effect of<i>Ocimum selloi</i>essential oil on the guinea-pig ileum" @default.
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- W2059868673 doi "https://doi.org/10.1080/14786419.2014.989392" @default.
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