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• W2059872783 abstract "Here we elaborated an analytical approach for the simulation of dose–response curves mediated by cellular receptors coupled to PLC and Ca 2+ mobilization. Based on a mathematical model of purinergic Ca 2+ signaling in taste cells, the analysis of taste cells responsiveness to nucleotides was carried out. Consistently with the expression of P2Y 2 and P2Y 4 receptors in taste cells, saturating ATP and UTP equipotently mobilized intracellular Ca 2+ . Cellular responses versus concentration of BzATP, a P2Y 2 agonist and a P2Y 4 antagonist, implicated high and low affinity BzATP receptors. Suramin modified the BzATP dose–response curve in a manner that suggested the low affinity receptor to be weakly sensitive to this P2Y antagonist. Given that solely P2Y 2 and P2Y 11 are BzATP receptors, their high sensitivity to suramin is poorly consistent with the suramin effects on BzATP responses. We simulated a variety of dose–response curves for different P2Y receptor sets and found that the appropriate fit of the overall pharmacological data was achievable only with dimeric receptors modeled as P2Y 2 /P2Y 4 homo- and heterodimers. Our computations and analytical analysis of experimental dose–response curves raise the possibility that ATP responsiveness of mouse taste cells is mediated by P2Y 2 and P2Y 4 receptors operative mostly in the dimeric form." @default.
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• W2059872783 date "2007-07-01" @default.
• W2059872783 modified "2023-09-23" @default.
• W2059872783 title "Modeling P2Y receptor–Ca2+ response coupling in taste cells" @default.
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• W2059872783 doi "https://doi.org/10.1016/j.bbamem.2007.04.002" @default.
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