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- W2059890719 abstract "Sera from 30 of 31 pediatric patients with Mycoplasma pneumoniae infections reacted with fine cytoplasmic fibrils in monolayers of rat or human fibroblasts and with peri- or juxtanuclear filament coils in fibroblasts pretreated with vinblastine. These staining patterns were identical with those obtained with sera with established anti-intermediate filament specificity but distinct from those obtained with anti-actin autoantibody. Twenty-four of the thirty positive sera also reacted with smooth muscle in frozen tissue sections. All the autoantibodies were of IgM class and most had a titer of 1:64. Sequential serum samples from 20 patients showed a fourfold or greater change in antibody titer. Eight of thrity-four hospital control sera showed similar staining patterns but IgM antibody titers were lower. These studies show that IgM autoantibodies to intermediate filaments occur frequently in sera from patients with M. pneumoniae infections." @default.
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- W2059890719 date "1981-03-01" @default.
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- W2059890719 title "IgM autoantibody to intermediate filaments in Mycoplasma pneumoniae infections" @default.
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- W2059890719 doi "https://doi.org/10.1016/0090-1229(81)90135-5" @default.
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