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- W2059893412 abstract "Acidic fibroblast growth factor (aFGF) induced a large increase in the type II 5′-deiodinase (5'D) activity in astroglial cells. This required a time lag of about 4 h. Half-maximal stimulation was obtained with about 7 ng/ml aFGF. This factor at 20 ng/ml induced several times more 5'D activity than did 20 ng/ml basic fibroblast growth factor (bFGF) after 8 h incubation. aFGF (20 ng/ml) produced a 10–50-fold increase in 5'D activity after 24 h, whereas the effect of 20 ng/ml bFGF had disappeared after 24 h. Heparin (17 μ/ml) potentiated the 5'D response to natural and recombinant aFGF. Glucocorticoids amplified the aFGF-induction of 5'D activity. This is the first demonstration in astroglial cells that a growth factor can regulate the 5'D activity." @default.
- W2059893412 created "2016-06-24" @default.
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- W2059893412 date "1990-05-01" @default.
- W2059893412 modified "2023-09-25" @default.
- W2059893412 title "Induction of 5′-deiodinase activity in rat astroglial cells by acidic fibroblast growth factor" @default.
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- W2059893412 doi "https://doi.org/10.1016/0165-3806(90)90012-n" @default.
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