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- W2059896836 abstract "A platform was developed to analyze MS/MS spectra from large peptides with low part-per-million mass accuracy, including a commercial-grade software suite. Termed Middle Down Proteomics, this platform identified 7454 peptides from 2−20 kDa (1472 unique) from 555 proteins after 23 LC-MS/MS injections of Lys-C digests of HeLa-S3 nuclear proteins. Along with greatly increased confidence for both peptide identification (expectation values from 10−89 to 10−4) and characterization (up to 18% of peptides were modified in some LC-MS/MS runs), fragmentation data with <2 ppm accuracy enabled error tolerant and routine multiplexed database searching–all clearly demonstrated in this study." @default.
- W2059896836 created "2016-06-24" @default.
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- W2059896836 date "2008-11-20" @default.
- W2059896836 modified "2023-10-15" @default.
- W2059896836 title "Tandem Mass Spectrometry with Ultrahigh Mass Accuracy Clarifies Peptide Identification by Database Retrieval" @default.
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- W2059896836 doi "https://doi.org/10.1021/pr800635m" @default.
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