FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059897240> ?p ?o ?g. }

• W2059897240 endingPage "e90339" @default.
• W2059897240 startingPage "e90339" @default.
• W2059897240 abstract "Impaired L-carnitine uptake correlates with higher blood pressure in adult men, and L-carnitine restores endothelial function in aortic rings from spontaneously hypertensive rat (SHR). Thus, endothelial dysfunction in hypertension could result from lower L-carnitine transport in this cell type. L-Carnitine transport is mainly mediated by novel organic cation transporters 1 (Octn1, Na(+)-independent) and 2 (Octn2, Na(+)-dependent); however, their kinetic properties and potential consequences in hypertension are unknown. We hypothesize that L-carnitine transport kinetic properties will be altered in aortic endothelium from spontaneously hypertensive rats (SHR). L-Carnitine transport was measured at different extracellular pH (pHo 5.5-8.5) in the absence or presence of sodium in rat aortic endothelial cells (RAECs) from non-hypertensive Wistar-Kyoto (WKY) rats and SHR. Octn1 and Octn2 mRNA relative expression was also determined. Dilation of endothelium-intact or denuded aortic rings in response to calcitonine gene related peptide (CGRP, 0.1-100 nmol/L) was measured (myography) in the absence or presence of L-carnitine. Total L-carnitine transport was lower in cells from SHR compared with WKY rats, an effect due to reduced Na(+)-dependent (Na(+) dep ) compared with Na(+)-independent (Na(+) indep ) transport components. Saturable L-carnitine transport kinetics show maximal velocity (V max), without changes in apparent K m for Na(+) indep transport in SHR compared with WKY rats. Total and Na(+) dep component of transport were increased, but Na(+) indep transport was reduced by extracellular alkalization in WKY rats. However, alkalization reduced total and Na(+) indep transport in cells from SHR. Octn2 mRNA was higher than Octn-1 mRNA expression in cells from both conditions. Dilation of artery rings in response to CGRP was reduced in vessels from SHR compared with WKY rats. CGRP effect was endothelium-dependent and restored by L-carnitine. All together these results suggest that reduced L-carnitine transport (likely via Na(+)-dependent Octn2) could limit this compound's potential beneficial effects in RAECs from SHR." @default.
• W2059897240 created "2016-06-24" @default.
• W2059897240 creator A5002035651 @default.
• W2059897240 creator A5022992144 @default.
• W2059897240 creator A5025057535 @default.
• W2059897240 creator A5027285492 @default.
• W2059897240 creator A5033804338 @default.
• W2059897240 creator A5048145260 @default.
• W2059897240 creator A5069080804 @default.
• W2059897240 creator A5071760018 @default.
• W2059897240 creator A5081007456 @default.
• W2059897240 creator A5082446349 @default.
• W2059897240 creator A5085117203 @default.
• W2059897240 creator A5087509422 @default.
• W2059897240 date "2014-02-28" @default.
• W2059897240 modified "2023-10-18" @default.
• W2059897240 title "Reduced L-Carnitine Transport in Aortic Endothelial Cells from Spontaneously Hypertensive Rats" @default.
• W2059897240 cites W1844834026 @default.
• W2059897240 cites W1927805387 @default.
• W2059897240 cites W1977244805 @default.
• W2059897240 cites W1978897080 @default.
• W2059897240 cites W1993933306 @default.
• W2059897240 cites W1998119299 @default.
• W2059897240 cites W2005683036 @default.
• W2059897240 cites W2007178177 @default.
• W2059897240 cites W2016457100 @default.
• W2059897240 cites W2023579083 @default.
• W2059897240 cites W2024892628 @default.
• W2059897240 cites W2025894603 @default.
• W2059897240 cites W2031153367 @default.
• W2059897240 cites W2033674260 @default.
• W2059897240 cites W2040167808 @default.
• W2059897240 cites W2043490416 @default.
• W2059897240 cites W2052681977 @default.
• W2059897240 cites W2053410451 @default.
• W2059897240 cites W2072938074 @default.
• W2059897240 cites W2073528685 @default.
• W2059897240 cites W2084295343 @default.
• W2059897240 cites W2087900886 @default.
• W2059897240 cites W2088256508 @default.
• W2059897240 cites W2092990515 @default.
• W2059897240 cites W2094318130 @default.
• W2059897240 cites W2098568040 @default.
• W2059897240 cites W2107277218 @default.
• W2059897240 cites W2120044173 @default.
• W2059897240 cites W2125339330 @default.
• W2059897240 cites W2127817159 @default.
• W2059897240 cites W2134032476 @default.
• W2059897240 cites W2136976156 @default.
• W2059897240 cites W2147635708 @default.
• W2059897240 cites W2159400209 @default.
• W2059897240 cites W2161007481 @default.
• W2059897240 cites W2161310946 @default.
• W2059897240 doi "https://doi.org/10.1371/journal.pone.0090339" @default.
• W2059897240 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3938671" @default.
• W2059897240 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24587332" @default.
• W2059897240 hasPublicationYear "2014" @default.
• W2059897240 type Work @default.
• W2059897240 sameAs 2059897240 @default.
• W2059897240 citedByCount "7" @default.
• W2059897240 countsByYear W20598972402015 @default.
• W2059897240 countsByYear W20598972402016 @default.
• W2059897240 countsByYear W20598972402021 @default.
• W2059897240 countsByYear W20598972402023 @default.
• W2059897240 crossrefType "journal-article" @default.
• W2059897240 hasAuthorship W2059897240A5002035651 @default.
• W2059897240 hasAuthorship W2059897240A5022992144 @default.
• W2059897240 hasAuthorship W2059897240A5025057535 @default.
• W2059897240 hasAuthorship W2059897240A5027285492 @default.
• W2059897240 hasAuthorship W2059897240A5033804338 @default.
• W2059897240 hasAuthorship W2059897240A5048145260 @default.
• W2059897240 hasAuthorship W2059897240A5069080804 @default.
• W2059897240 hasAuthorship W2059897240A5071760018 @default.
• W2059897240 hasAuthorship W2059897240A5081007456 @default.
• W2059897240 hasAuthorship W2059897240A5082446349 @default.
• W2059897240 hasAuthorship W2059897240A5085117203 @default.
• W2059897240 hasAuthorship W2059897240A5087509422 @default.
• W2059897240 hasBestOaLocation W20598972401 @default.
• W2059897240 hasConcept C120770815 @default.
• W2059897240 hasConcept C123012128 @default.
• W2059897240 hasConcept C126322002 @default.
• W2059897240 hasConcept C134018914 @default.
• W2059897240 hasConcept C178790620 @default.
• W2059897240 hasConcept C185592680 @default.
• W2059897240 hasConcept C202751555 @default.
• W2059897240 hasConcept C2776992346 @default.
• W2059897240 hasConcept C2778086073 @default.
• W2059897240 hasConcept C2778435403 @default.
• W2059897240 hasConcept C28406088 @default.
• W2059897240 hasConcept C537181965 @default.
• W2059897240 hasConcept C55493867 @default.
• W2059897240 hasConcept C71924100 @default.
• W2059897240 hasConcept C84393581 @default.
• W2059897240 hasConceptScore W2059897240C120770815 @default.
• W2059897240 hasConceptScore W2059897240C123012128 @default.
• W2059897240 hasConceptScore W2059897240C126322002 @default.
• W2059897240 hasConceptScore W2059897240C134018914 @default.
• W2059897240 hasConceptScore W2059897240C178790620 @default.

• next