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- W2059897265 abstract "<h3>Background/aims:</h3> To evaluate microbial contamination of multiply used preservative-free artificial tears packed in reclosable containers after daily use. <h3>Methods:</h3> Subjects were provided with preservative-free artificial tears (Groups 1 and 2) and artificial tears containing a preservative (Group 3). After administration three times or more per 10 h, bottles were collected, and any remaining fluid in the bottles was cultured. A risk factor analysis for microbial contamination was performed by the use of univariate and multivariate analysis. <h3>Results:</h3> A total of 242 eye-drop bottles were evaluated. Five (2.0%) of the 242 bottles had bacterial contamination. In group 1, four (3.9%) of 102 bottles were contaminated, and identified bacteria were all coagulase-negative <i>Staphylococcus</i>. In group 2, one (1.0%) of 105 bottles was contaminated, and it was a Gram-negative <i>Acinetobacter</i> species. No bottles from group 3 showed any contamination. Based on multivariate analysis, advanced age and fingertip touch were statistically significant risk factors for microbial contamination (p<0.05). <h3>Conclusion:</h3> Preservative-free artificial tears in reclosable containers are at risk of contamination in a daily and multiple use setting, especially in patients with a poor administering technique, which is associated with fingertip touch and advanced age." @default.
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- W2059897265 date "2008-09-09" @default.
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- W2059897265 title "Microbial contamination of multiply used preservative-free artificial tears packed in reclosable containers" @default.
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- W2059897265 doi "https://doi.org/10.1136/bjo.2008.144469" @default.
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