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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059897759> ?p ?o ?g. }

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• W2059897759 abstract "When fluoroquinolones bind to gyrase or topoisomerase IV in the presence of DNA, they alter protein conformation. DNA cleavage results with diminished religation, so the enzymes are trapped in ternary complexes with drug and cleaved DNA. Preferential localization of gyrase ahead of replication forks and topoisomerase IV behind them causes fluoroquinolone-mediated complexes with the two enzymes to have different physiological consequences." @default.
• W2059897759 created "2016-06-24" @default.
• W2059897759 creator A5066266492 @default.
• W2059897759 date "1999-10-01" @default.
• W2059897759 modified "2023-10-03" @default.
• W2059897759 title "Mechanism of fluoroquinolone action" @default.
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• W2059897759 doi "https://doi.org/10.1016/s1369-5274(99)00008-9" @default.
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