Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059898400> ?p ?o ?g. }
- W2059898400 endingPage "821" @default.
- W2059898400 startingPage "817" @default.
- W2059898400 abstract "Using siRNA-mediated gene silencing in cultured adipocytes, we have dissected the insulin-signalling pathway leading to translocation of GLUT4 glucose transporters to the plasma membrane. RNAi (RNA interference)-based depletion of components in the putative TC10 pathway (CAP, CrkII and c-Cbl plus Cbl-b) or the phospholipase Cγ pathway failed to diminish insulin signalling to GLUT4. Within the phosphoinositide 3-kinase pathway, loss of the 5′-phosphatidylinositol 3,4,5-trisphosphate phosphatase SHIP2 was also without effect, whereas depletion of the 3′-phosphatase PTEN significantly enhanced insulin action. Downstream of phosphatidylinositol 3,4,5-trisphosphate and PDK1, silencing the genes encoding the protein kinases Akt1/PKBα, or CISK(SGK3) or protein kinases Cλ/ζ had little or no effect, but loss of Akt2/PKBβ significantly attenuated GLUT4 regulation by insulin. These results show that Akt2/PKBβ is the key downstream intermediate within the phosphoinositide 3-kinase pathway linked to insulin action on GLUT4 in cultured adipocytes, whereas PTEN is a potent negative regulator of this pathway." @default.
- W2059898400 created "2016-06-24" @default.
- W2059898400 creator A5001800121 @default.
- W2059898400 creator A5015721009 @default.
- W2059898400 creator A5019443505 @default.
- W2059898400 creator A5024157816 @default.
- W2059898400 creator A5031610305 @default.
- W2059898400 creator A5050666239 @default.
- W2059898400 creator A5060346815 @default.
- W2059898400 creator A5061430640 @default.
- W2059898400 creator A5066429160 @default.
- W2059898400 creator A5082021567 @default.
- W2059898400 creator A5085687728 @default.
- W2059898400 date "2004-10-26" @default.
- W2059898400 modified "2023-09-30" @default.
- W2059898400 title "Analysis of insulin signalling by RNAi-based gene silencing" @default.
- W2059898400 cites W1576809876 @default.
- W2059898400 cites W1583005540 @default.
- W2059898400 cites W1613943426 @default.
- W2059898400 cites W1674259800 @default.
- W2059898400 cites W1979801144 @default.
- W2059898400 cites W1981043027 @default.
- W2059898400 cites W1989294105 @default.
- W2059898400 cites W1994376108 @default.
- W2059898400 cites W2004102471 @default.
- W2059898400 cites W2004767178 @default.
- W2059898400 cites W2009181620 @default.
- W2059898400 cites W2012079492 @default.
- W2059898400 cites W2013044317 @default.
- W2059898400 cites W2013829707 @default.
- W2059898400 cites W2032868089 @default.
- W2059898400 cites W2040143421 @default.
- W2059898400 cites W2053073281 @default.
- W2059898400 cites W2062244719 @default.
- W2059898400 cites W2070726224 @default.
- W2059898400 cites W2073635502 @default.
- W2059898400 cites W2084484618 @default.
- W2059898400 cites W2086752996 @default.
- W2059898400 cites W2087236819 @default.
- W2059898400 cites W2101400542 @default.
- W2059898400 cites W2118376852 @default.
- W2059898400 cites W2128710251 @default.
- W2059898400 cites W2128842224 @default.
- W2059898400 cites W2133790985 @default.
- W2059898400 cites W2138391708 @default.
- W2059898400 cites W2143947670 @default.
- W2059898400 cites W2147207624 @default.
- W2059898400 cites W2159990074 @default.
- W2059898400 cites W2160361307 @default.
- W2059898400 cites W2171814772 @default.
- W2059898400 cites W4381322599 @default.
- W2059898400 doi "https://doi.org/10.1042/bst0320817" @default.
- W2059898400 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15494023" @default.
- W2059898400 hasPublicationYear "2004" @default.
- W2059898400 type Work @default.
- W2059898400 sameAs 2059898400 @default.
- W2059898400 citedByCount "86" @default.
- W2059898400 countsByYear W20598984002012 @default.
- W2059898400 countsByYear W20598984002013 @default.
- W2059898400 countsByYear W20598984002014 @default.
- W2059898400 countsByYear W20598984002015 @default.
- W2059898400 countsByYear W20598984002016 @default.
- W2059898400 countsByYear W20598984002017 @default.
- W2059898400 countsByYear W20598984002018 @default.
- W2059898400 countsByYear W20598984002019 @default.
- W2059898400 countsByYear W20598984002020 @default.
- W2059898400 countsByYear W20598984002021 @default.
- W2059898400 countsByYear W20598984002023 @default.
- W2059898400 crossrefType "journal-article" @default.
- W2059898400 hasAuthorship W2059898400A5001800121 @default.
- W2059898400 hasAuthorship W2059898400A5015721009 @default.
- W2059898400 hasAuthorship W2059898400A5019443505 @default.
- W2059898400 hasAuthorship W2059898400A5024157816 @default.
- W2059898400 hasAuthorship W2059898400A5031610305 @default.
- W2059898400 hasAuthorship W2059898400A5050666239 @default.
- W2059898400 hasAuthorship W2059898400A5060346815 @default.
- W2059898400 hasAuthorship W2059898400A5061430640 @default.
- W2059898400 hasAuthorship W2059898400A5066429160 @default.
- W2059898400 hasAuthorship W2059898400A5082021567 @default.
- W2059898400 hasAuthorship W2059898400A5085687728 @default.
- W2059898400 hasConcept C104317684 @default.
- W2059898400 hasConcept C112446052 @default.
- W2059898400 hasConcept C119056186 @default.
- W2059898400 hasConcept C11960822 @default.
- W2059898400 hasConcept C134018914 @default.
- W2059898400 hasConcept C154137905 @default.
- W2059898400 hasConcept C161573976 @default.
- W2059898400 hasConcept C166703698 @default.
- W2059898400 hasConcept C178666793 @default.
- W2059898400 hasConcept C184235292 @default.
- W2059898400 hasConcept C185592680 @default.
- W2059898400 hasConcept C2776188179 @default.
- W2059898400 hasConcept C2777391703 @default.
- W2059898400 hasConcept C2777609662 @default.
- W2059898400 hasConcept C2779306644 @default.
- W2059898400 hasConcept C2780610907 @default.
- W2059898400 hasConcept C55493867 @default.
- W2059898400 hasConcept C62478195 @default.