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- W2059905961 abstract "Entamoeba histolytica, as its name suggests, is an enteric parasite with a remarkable ability to lyse host tissues. However, the interaction of the parasite with the host is more complex than solely destruction and invasion. It is at the host-parasite interface that cell-signaling events commit the parasite to (a) commensal, noninvasive infection, (b) developmental change from trophozoite to cyst, or (c) invasion and potential death of the human host. The molecule central to these processes is an amebic cell surface protein that recognizes the sugars galactose (Gal) and N-acetylgalactosamine (GalNAc) on the surface of host cells. Engagement of the Gal/GalNAc lectin to the host results in cytoskeletal reorganization in the parasite. The parasite cytoskeleton regulates the extracellular adhesive activity of the lectin and recruits to the host-parasite interface factors required for parasite survival within its host. If the parasite lectin attaches to the host mucin glycoproteins lining the intestine, the result is commensal infection. In contrast, attachment of the lectin to a host cell surface glycoprotein leads to lectin-induced host cell calcium transients, caspase activation, and destruction via apoptosis. Finally, trophozoite quorum sensing via the lectin initiates the developmental pathway resulting in encystment. The structure and function of the lectin that controls these divergent cell biologic processes are the subject of this review." @default.
- W2059905961 created "2016-06-24" @default.
- W2059905961 creator A5031444461 @default.
- W2059905961 creator A5050404191 @default.
- W2059905961 creator A5068198671 @default.
- W2059905961 date "2002-10-01" @default.
- W2059905961 modified "2023-10-14" @default.
- W2059905961 title "The Bittersweet Interface of Parasite and Host: Lectin-Carbohydrate Interactions During Human Invasion by the Parasite<i>Entamoeba histolytica</i>" @default.
- W2059905961 cites W1502698470 @default.
- W2059905961 cites W1504615345 @default.
- W2059905961 cites W1562624833 @default.
- W2059905961 cites W1575340050 @default.
- W2059905961 cites W1607418934 @default.
- W2059905961 cites W1732196838 @default.
- W2059905961 cites W1763341724 @default.
- W2059905961 cites W1856839824 @default.
- W2059905961 cites W1891275553 @default.
- W2059905961 cites W1895094151 @default.
- W2059905961 cites W1898723704 @default.
- W2059905961 cites W1969625067 @default.
- W2059905961 cites W1975112998 @default.
- W2059905961 cites W1975888859 @default.
- W2059905961 cites W1978574333 @default.
- W2059905961 cites W1984115223 @default.
- W2059905961 cites W1985285837 @default.
- W2059905961 cites W1985689820 @default.
- W2059905961 cites W1989434675 @default.
- W2059905961 cites W1992333002 @default.
- W2059905961 cites W1992363176 @default.
- W2059905961 cites W1994270410 @default.
- W2059905961 cites W1995980810 @default.
- W2059905961 cites W1997366474 @default.
- W2059905961 cites W1999138666 @default.
- W2059905961 cites W2004948172 @default.
- W2059905961 cites W2004953706 @default.
- W2059905961 cites W2008234595 @default.
- W2059905961 cites W2009788795 @default.
- W2059905961 cites W2013057252 @default.
- W2059905961 cites W2016035538 @default.
- W2059905961 cites W2017498252 @default.
- W2059905961 cites W2021463777 @default.
- W2059905961 cites W2038924892 @default.
- W2059905961 cites W2043827833 @default.
- W2059905961 cites W2046259774 @default.
- W2059905961 cites W2047034243 @default.
- W2059905961 cites W2050906170 @default.
- W2059905961 cites W2054895986 @default.
- W2059905961 cites W2061102152 @default.
- W2059905961 cites W2063773849 @default.
- W2059905961 cites W2067850556 @default.
- W2059905961 cites W2074196529 @default.
- W2059905961 cites W2075243485 @default.
- W2059905961 cites W2081407238 @default.
- W2059905961 cites W2081408903 @default.
- W2059905961 cites W2083471669 @default.
- W2059905961 cites W2084257585 @default.
- W2059905961 cites W2090484375 @default.
- W2059905961 cites W2102464506 @default.
- W2059905961 cites W2102504192 @default.
- W2059905961 cites W2105359514 @default.
- W2059905961 cites W2105788168 @default.
- W2059905961 cites W2106516654 @default.
- W2059905961 cites W2110671908 @default.
- W2059905961 cites W2118981560 @default.
- W2059905961 cites W2120564941 @default.
- W2059905961 cites W2124528638 @default.
- W2059905961 cites W2125213202 @default.
- W2059905961 cites W2125633042 @default.
- W2059905961 cites W2127593648 @default.
- W2059905961 cites W2133369891 @default.
- W2059905961 cites W2133709316 @default.
- W2059905961 cites W2134021782 @default.
- W2059905961 cites W2136886068 @default.
- W2059905961 cites W2140238241 @default.
- W2059905961 cites W2149586883 @default.
- W2059905961 cites W2153032002 @default.
- W2059905961 cites W2166373075 @default.
- W2059905961 cites W2170722556 @default.
- W2059905961 cites W2188443042 @default.
- W2059905961 cites W2196613517 @default.
- W2059905961 cites W2275797282 @default.
- W2059905961 cites W2405233669 @default.
- W2059905961 cites W2412812882 @default.
- W2059905961 cites W4239828048 @default.
- W2059905961 cites W4298455857 @default.
- W2059905961 cites W7887161 @default.
- W2059905961 doi "https://doi.org/10.1146/annurev.micro.56.012302.160959" @default.
- W2059905961 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12142490" @default.
- W2059905961 hasPublicationYear "2002" @default.
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