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- W2059934525 abstract "Article1 May 1964Observations on Patients with Laennec's Cirrhosis Receiving Alcohol While on Controlled DietsESAT ERENOGLU, M.D., JUAN G. EDREIRA, M.D., ARTHUR J. PATEK JR., M.D.ESAT ERENOGLU, M.D.Search for more papers by this author, JUAN G. EDREIRA, M.D.Search for more papers by this author, ARTHUR J. PATEK JR., M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-60-5-814 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe close relationship between chronic alcoholism and Laennec's cirrhosis has been known for many years, but the manner in which alcoholism predisposes to cirrhosis of the liver is not understood. On the basis of clinical observations (1-3) it has been suggested that malnutrition may play an important etiological role in alcoholic cirrhosis, since the patients generally are malnourished, and since hepatic functions improve when patients are fed a nutritious diet and are deprived of alcohol. There is evidence that the ingestion of alcohol increases nutritional imbalance by providing calories without essential nutrients. Such a mechanism has been postulated as the...References1. PATEK AJ: Treatment of alcoholic cirrhosis of the liver with high vitamin therapy. Proc. Soc. Exp. Biol. Med. 37: 329, 1937. CrossrefGoogle Scholar2. PATEKPOST AJJ: Treatment of cirrhosis of the liver by a nutritious diet and supplements rich in vitamin B complex. J. Clin. Invest. 20: 481, 1941. CrossrefMedlineGoogle Scholar3. PATEKPOSTRATNOFFMANKINHILLMAN AJJODHRW: Dietary treatment of cirrhosis of the liver. Results in 124 patients observed during a 10 year period. JAMA 138: 543, 1948. CrossrefMedlineGoogle Scholar4. SPIESDEWOLF TDHF: Observations on the etiological relationship of severe alcoholism in pellagra. Amer. J. Med. Sci. 186: 521, 1933. CrossrefGoogle Scholar5. STRAUSS MB: Etiology of alcoholic polyneuritis. Amer. J. Med. Sci. 189: 378, 1935. CrossrefGoogle Scholar6. BLUMBERGMCCOLLUM HEV: Prevention by choline of liver cirrhosis in rats on high fat, low protein diets. Science 93: 598, 1941. CrossrefMedlineGoogle Scholar7. DAFTSEBRELLLILLIE FSWHRD: Production and apparent prevention of a dietary liver cirrhosis in rats. Proc. Soc. Exp. Biol. Med. 48: 228, 1941. CrossrefGoogle Scholar8. WEBSTER GT: Cirrhosis of the liver among rats receiving diets poor in protein and rich in fat. J. Clin. Invest. 21: 385, 1942. CrossrefMedlineGoogle Scholar9. GYÖRGYGOLDBLATT PH: Observations on conditions of dietary hepatic injury (necrosis, cirrhosis) in rats. J. Exp. Med. 75: 355, 1942. CrossrefMedlineGoogle Scholar10. WILGRAM GF: Experimental Laennec type of cirrhosis in monkeys. Ann. Intern. Med. 51: 1134, 1959. LinkGoogle Scholar11. MOON VH: Experimental cirrhosis in relation to human cirrhosis. Arch. Path. (Chicago) 18: 381, 1934. Google Scholar12. LOWRYASHBURNDAFTSEBRELL JVLLFSWH: Effect of alcohol in experimental liver cirrhosis. Quart. J. Stud. Alcohol 3: 168, 1942. CrossrefGoogle Scholar13. BESTHARTROFTLUCASRIDOUT CHWSCCJH: Liver damage produced by feeding alcohol or sugar, and its prevention by choline. Brit. Med. J. 2: 1001, 1949. CrossrefGoogle Scholar14. KLATSKINKREHLCONN GWAHO: Effect of alcohol on choline requirement: changes in rat's liver following prolonged ingestion of alcohol. J. Exp. Med. 100: 605, 1954. CrossrefMedlineGoogle Scholar15. WESTERFIELD WW: The intermediary metabolism of alcohol. Amer. J. Clin. Nutr. 9: 426, 1961. CrossrefMedlineGoogle Scholar16. LIEBERDAVIDSON CSCS: Some metabolic effects of ethyl alcohol. Amer. J. Med. 33: 319, 1962. CrossrefMedlineGoogle Scholar17. LIEBERJONESMENDELSONDECARLIDAVIDSON CSDBJLMCS: Fatty liver, hyperlipemia and hyperuricemia produced by prolonged alcohol consumption, despite adequate dietary intake. Trans. Ass. Amer. Physicians 76: 289, 1963. Google Scholar18. ZIEVEHILL LE: Influence of alcohol consumption on hepatic function in healthy gainfully employed men. J. Lab. Clin. Med. 42: 705, 1953. MedlineGoogle Scholar19. VOLWILERJONESMALLORY WCMTB: Criteria for the measurement of results of treatment in fatty cirrhosis. Gastroenterology 11: 164, 1948. MedlineGoogle Scholar20. SUMMERSKILLWOLFEDAVIDSON WHSJCS: Response to alcohol in chronic alcoholics with liver disease: clinical, pathological, and metabolic changes. Lancet 1: 335, 1957. CrossrefGoogle Scholar21. PHILLIPSDAVIDSON GBCS: Acute hepatic insufficiency of the chronic alcoholic: clinical and pathological study. Arch. Intern. Med. (Chicago) 94: 585, 1954. CrossrefGoogle Scholar22. POPPERSZANTO HPB: Fatty liver with hepatic failure in alcoholics. J. Mount Sinai Hosp. NY 24: 1121, 1957. MedlineGoogle Scholar23. BECKETTLIVINGSTONEHILL AGAVKR: Acute alcoholic hepatitis. Brit. Med. J. 2: 1113, 1961. CrossrefMedlineGoogle Scholar24. GREENMISTILISSCHIFF JSL: Acute alcoholic hepatitis: a clinical study of fifty cases. Arch. Intern. Med. (Chicago) 112: 113, 1963. CrossrefGoogle Scholar25. PHILLIPSGABUZDADAVISON GBGJC: Comparative effects of a purified and an adequate diet on the course of fatty cirrhosis in the alcoholic. J. Clin. Invest. 31: 351, 1952. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, New YorkFrom the Columbia University Research Service, Goldwater Memorial Hospital, and the Department of Medicine, Columbia University, College of Physicians and Surgeons, New York, New York.This investigation was supported by grant A-2178 from the Institute of Arthritis and Metabolic Disorders, the Bourne Fund for the Study of Hepatic Disease, and the Health Research Council of the City of New York under contract U-1017.Requests for reprints should be addressed to Arthur J. Patek, Jr., M.D., Columbia University Research Service, Goldwater Memorial Hospital, Welfare Island, New York, New York. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAlcoholic liver damage-toxicity, autoimmunity and allergyReview articles : Alcohol and palliative careAlcoholic Liver DiseaseEffect of parenteral amino acid supplementation in alcoholic hepatitisClinical and Therapeutic Aspects of Alcoholic Liver DiseaseAcute hepatic insufficiency of the chronic alcoholic—RevisitedClinical Utilization of Alkaline Phosphatase MeasurementsEffects of Ethanol on Nutritional Status10 Alcohol and the alimentary systemLiver Disease in AlcoholismTherapeutic Considerations in Selected Forms of Acute and Chronic Liver DiseaseAlcohol and the liver.Factors Influencing the Prognosis of the Alcoholic Patient with CirrhosisAlcohol and liver diseaseCirrhosis in AlcoholicsMalnutrition and liver disease—An overemphasized relationshipDuration of survival in patients with Laennec's cirrhosisEthanol and the LiverHepatic and Metabolic Effects of AlcoholAlcohol and the Liver 1 May 1964Volume 60, Issue 5Page: 814-823KeywordsAlcoholismAlcoholsCirrhosisDietHospital medicineIngestionLiverMetabolic disordersProteinsSurgeons ePublished: 1 December 2008 Issue Published: 1 May 1964 PDF downloadLoading ..." @default.
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