Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059940903> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2059940903 endingPage "358" @default.
- W2059940903 startingPage "351" @default.
- W2059940903 abstract "The effects of nifedipine (40-100 mumol/kg), nitrendipine (40 and 80 mumol/kg), hydralazine (381 and 763 mumol/kg), felodipine (12 mumol/kg), and the pharmacologically inactive first-step metabolite of felodipine, H152/37 (80 mumol/kg) were studied in rabbits (New Zeeland White) after oral administration on day 16 of gestation. The vasodilating drugs--nifedipine, nitrendipine, felodipine, and hydralazine--all induced digital defects in the fetuses. The defects consisted of a reduction, absence, or abnormal structure of the distal phalanx of especially the fourth digit on the hind paw(s). Histologically, a disturbed differentiation of the cartilage, and secondarily also of the ossification centre and joint structure of the distal phalanx, was observed. In contrast, no digital abnormalities were observed after administration of vehicle or H152/37. The findings that vasodilators with different structures, like dihydropyridines and hydralazine, induced the same type of digital defects strongly suggest that the observed phalangeal defects are secondary to pharmacological action, and not related to chemical structure. A decrease in uteroplacental blood flow, caused by excessive hypotension, is discussed as the most probable mechanism underlying the observed defects." @default.
- W2059940903 created "2016-06-24" @default.
- W2059940903 creator A5029616681 @default.
- W2059940903 creator A5067738915 @default.
- W2059940903 creator A5075223480 @default.
- W2059940903 creator A5081928550 @default.
- W2059940903 date "1989-10-01" @default.
- W2059940903 modified "2023-10-03" @default.
- W2059940903 title "Digital defects induced by vasodilating agents: Relationship to reduction in uteroplacental blood flow" @default.
- W2059940903 cites W1548208927 @default.
- W2059940903 cites W1965016127 @default.
- W2059940903 cites W1986039138 @default.
- W2059940903 cites W1986475553 @default.
- W2059940903 cites W1996558914 @default.
- W2059940903 cites W1999583795 @default.
- W2059940903 cites W2005204837 @default.
- W2059940903 cites W2006078398 @default.
- W2059940903 cites W2024162868 @default.
- W2059940903 cites W2025421356 @default.
- W2059940903 cites W2042496531 @default.
- W2059940903 cites W2061540614 @default.
- W2059940903 cites W2098095640 @default.
- W2059940903 cites W2141468969 @default.
- W2059940903 cites W2197227471 @default.
- W2059940903 doi "https://doi.org/10.1002/tera.1420400407" @default.
- W2059940903 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2814896" @default.
- W2059940903 hasPublicationYear "1989" @default.
- W2059940903 type Work @default.
- W2059940903 sameAs 2059940903 @default.
- W2059940903 citedByCount "59" @default.
- W2059940903 countsByYear W20599409032012 @default.
- W2059940903 countsByYear W20599409032015 @default.
- W2059940903 countsByYear W20599409032016 @default.
- W2059940903 countsByYear W20599409032018 @default.
- W2059940903 countsByYear W20599409032019 @default.
- W2059940903 countsByYear W20599409032021 @default.
- W2059940903 crossrefType "journal-article" @default.
- W2059940903 hasAuthorship W2059940903A5029616681 @default.
- W2059940903 hasAuthorship W2059940903A5067738915 @default.
- W2059940903 hasAuthorship W2059940903A5075223480 @default.
- W2059940903 hasAuthorship W2059940903A5081928550 @default.
- W2059940903 hasConcept C105702510 @default.
- W2059940903 hasConcept C120770815 @default.
- W2059940903 hasConcept C126322002 @default.
- W2059940903 hasConcept C134018914 @default.
- W2059940903 hasConcept C185592680 @default.
- W2059940903 hasConcept C2777022698 @default.
- W2059940903 hasConcept C2777477808 @default.
- W2059940903 hasConcept C2779066535 @default.
- W2059940903 hasConcept C2780521442 @default.
- W2059940903 hasConcept C2780548744 @default.
- W2059940903 hasConcept C2780648877 @default.
- W2059940903 hasConcept C519063684 @default.
- W2059940903 hasConcept C71924100 @default.
- W2059940903 hasConcept C84393581 @default.
- W2059940903 hasConcept C98274493 @default.
- W2059940903 hasConceptScore W2059940903C105702510 @default.
- W2059940903 hasConceptScore W2059940903C120770815 @default.
- W2059940903 hasConceptScore W2059940903C126322002 @default.
- W2059940903 hasConceptScore W2059940903C134018914 @default.
- W2059940903 hasConceptScore W2059940903C185592680 @default.
- W2059940903 hasConceptScore W2059940903C2777022698 @default.
- W2059940903 hasConceptScore W2059940903C2777477808 @default.
- W2059940903 hasConceptScore W2059940903C2779066535 @default.
- W2059940903 hasConceptScore W2059940903C2780521442 @default.
- W2059940903 hasConceptScore W2059940903C2780548744 @default.
- W2059940903 hasConceptScore W2059940903C2780648877 @default.
- W2059940903 hasConceptScore W2059940903C519063684 @default.
- W2059940903 hasConceptScore W2059940903C71924100 @default.
- W2059940903 hasConceptScore W2059940903C84393581 @default.
- W2059940903 hasConceptScore W2059940903C98274493 @default.
- W2059940903 hasIssue "4" @default.
- W2059940903 hasLocation W20599409031 @default.
- W2059940903 hasLocation W20599409032 @default.
- W2059940903 hasOpenAccess W2059940903 @default.
- W2059940903 hasPrimaryLocation W20599409031 @default.
- W2059940903 hasRelatedWork W1963772301 @default.
- W2059940903 hasRelatedWork W2020214582 @default.
- W2059940903 hasRelatedWork W2032672894 @default.
- W2059940903 hasRelatedWork W2033902643 @default.
- W2059940903 hasRelatedWork W2067142549 @default.
- W2059940903 hasRelatedWork W2120603485 @default.
- W2059940903 hasRelatedWork W2267993927 @default.
- W2059940903 hasRelatedWork W317121104 @default.
- W2059940903 hasRelatedWork W4237466943 @default.
- W2059940903 hasRelatedWork W4911587 @default.
- W2059940903 hasVolume "40" @default.
- W2059940903 isParatext "false" @default.
- W2059940903 isRetracted "false" @default.
- W2059940903 magId "2059940903" @default.
- W2059940903 workType "article" @default.