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- W2059943310 abstract "The p53 tumor suppressor protein induces cell cycle arrest or apoptosis in response to cellular stresses. We have identified PRG3 (53-esponsive ene 3), which is induced specifically under p53-dependent apoptotic conditions in human colon cancer cells, and encodes a novel polypeptide of 373 amino acids with a predicted molecular mass of 40.5 kDa. PRG3 has significant homology to bacterial oxidoreductases and the apoptosis-inducing factor, AIF, and the gene was assigned to chromosome 10q21.3–q22.1. Expression of PRG3 was induced by the activation of endogenous p53 and it contains a p53-responsive element. Unlike AIF, PRG3 localizes in the cytoplasm and its ectopic expression induces apoptosis. An amino-terminal deletion mutant of PRG3 that lacks a putative oxidoreductase activity retains its apoptotic activity, suggesting that the oxidoreductase activity is dispensable for the apoptotic function of PRG3. The PRG3 gene is thus a novel p53 target gene in a p53-dependent apoptosis pathway." @default.
- W2059943310 created "2016-06-24" @default.
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- W2059943310 date "2002-07-12" @default.
- W2059943310 modified "2023-10-14" @default.
- W2059943310 title "A novel p53-inducible apoptogenic gene, PRG3, encodes a homologue of the apoptosis-inducing factor (AIF)" @default.
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- W2059943310 doi "https://doi.org/10.1016/s0014-5793(02)03049-1" @default.
- W2059943310 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12135761" @default.
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