Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059946724> ?p ?o ?g. }
- W2059946724 endingPage "189" @default.
- W2059946724 startingPage "183" @default.
- W2059946724 abstract "ABSTRACT: Oxidative stress has been implicated in the pathogenesis of male infertility. Paraoxonase‐1 (PON‐1) is a high‐density lipoprotein—associated antioxidant enzyme that prevents oxidative modification of low‐density lipoprotein. Our aims in the study were to investigate 1) seminal PON‐1 activity in subfertile men and 2) whether seminal PON‐1 activity had any relationship to semen parameters. The study included 28 men with idiopathic subfertility, 32 subfertile men with abnormal semen parameters, and 30 fertile male volunteers. Seminal PON‐1 activity was measured spectrophotometrically. Seminal total antioxidant status (TAS) and total oxidant status (TOS) were determined by using colorimetric methods. Oxidative stress index (OSI) was calculated as ([TOS/TAS] × 100). TOS and OSI were significantly higher and PON‐1 activity and TAS were significantly lower in subfertile men with abnormal semen parameters than in men with idiopathic subfertility and fertile donors. PON‐1 activity was also strongly correlated with sperm concentration ( r = .68, P < .0001), motility ( r = .58, P < .0001), and morphology ( r = .62, P < .0001) in the overall group. The receiver operating characteristic curve analysis revealed a high diagnostic value for PON‐1 activity with respect to male‐factor subfertility, with an area under curve of .95 (95% confidence interval = 0.89–1.01), sensitivity = 97%, and specificity = 88%. Men with abnormal semen parameters have decreased levels of PON‐1 activity in their seminal plasma. This may play an important role in the pathogenesis of male‐factor subfertility." @default.
- W2059946724 created "2016-06-24" @default.
- W2059946724 creator A5022414467 @default.
- W2059946724 creator A5031622100 @default.
- W2059946724 creator A5034832251 @default.
- W2059946724 creator A5046609479 @default.
- W2059946724 creator A5090539676 @default.
- W2059946724 date "2009-03-04" @default.
- W2059946724 modified "2023-10-15" @default.
- W2059946724 title "Paraoxonase-1 Activity in Subfertile Men and Relationship to Sperm Parameters" @default.
- W2059946724 cites W1522744416 @default.
- W2059946724 cites W163461100 @default.
- W2059946724 cites W1964439944 @default.
- W2059946724 cites W1966657398 @default.
- W2059946724 cites W1976464405 @default.
- W2059946724 cites W1977544074 @default.
- W2059946724 cites W1989070741 @default.
- W2059946724 cites W1996944297 @default.
- W2059946724 cites W1997816306 @default.
- W2059946724 cites W1998927777 @default.
- W2059946724 cites W2001507834 @default.
- W2059946724 cites W2004274286 @default.
- W2059946724 cites W2007400083 @default.
- W2059946724 cites W2012834318 @default.
- W2059946724 cites W2025679035 @default.
- W2059946724 cites W2029148679 @default.
- W2059946724 cites W2035341151 @default.
- W2059946724 cites W2042203706 @default.
- W2059946724 cites W2045954291 @default.
- W2059946724 cites W2048607595 @default.
- W2059946724 cites W2053192002 @default.
- W2059946724 cites W2067193448 @default.
- W2059946724 cites W2084075677 @default.
- W2059946724 cites W2087736738 @default.
- W2059946724 cites W2092206306 @default.
- W2059946724 cites W2093022509 @default.
- W2059946724 cites W2095238796 @default.
- W2059946724 cites W2096206245 @default.
- W2059946724 cites W2108883609 @default.
- W2059946724 cites W2130091538 @default.
- W2059946724 cites W2130558040 @default.
- W2059946724 cites W2130820799 @default.
- W2059946724 cites W2132323127 @default.
- W2059946724 cites W2141850835 @default.
- W2059946724 cites W2147769323 @default.
- W2059946724 cites W2148883753 @default.
- W2059946724 cites W2164252826 @default.
- W2059946724 cites W2168115093 @default.
- W2059946724 cites W2168610597 @default.
- W2059946724 cites W2169474580 @default.
- W2059946724 cites W2169498039 @default.
- W2059946724 cites W2170794875 @default.
- W2059946724 cites W2241490343 @default.
- W2059946724 cites W4238251256 @default.
- W2059946724 cites W4297086712 @default.
- W2059946724 cites W64501005 @default.
- W2059946724 doi "https://doi.org/10.2164/jandrol.108.004929" @default.
- W2059946724 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18930907" @default.
- W2059946724 hasPublicationYear "2009" @default.
- W2059946724 type Work @default.
- W2059946724 sameAs 2059946724 @default.
- W2059946724 citedByCount "37" @default.
- W2059946724 countsByYear W20599467242012 @default.
- W2059946724 countsByYear W20599467242013 @default.
- W2059946724 countsByYear W20599467242014 @default.
- W2059946724 countsByYear W20599467242015 @default.
- W2059946724 countsByYear W20599467242016 @default.
- W2059946724 countsByYear W20599467242017 @default.
- W2059946724 countsByYear W20599467242018 @default.
- W2059946724 countsByYear W20599467242019 @default.
- W2059946724 countsByYear W20599467242021 @default.
- W2059946724 countsByYear W20599467242022 @default.
- W2059946724 crossrefType "journal-article" @default.
- W2059946724 hasAuthorship W2059946724A5022414467 @default.
- W2059946724 hasAuthorship W2059946724A5031622100 @default.
- W2059946724 hasAuthorship W2059946724A5034832251 @default.
- W2059946724 hasAuthorship W2059946724A5046609479 @default.
- W2059946724 hasAuthorship W2059946724A5090539676 @default.
- W2059946724 hasBestOaLocation W20599467241 @default.
- W2059946724 hasConcept C126322002 @default.
- W2059946724 hasConcept C134018914 @default.
- W2059946724 hasConcept C16685009 @default.
- W2059946724 hasConcept C2776151105 @default.
- W2059946724 hasConcept C2776509667 @default.
- W2059946724 hasConcept C2777338322 @default.
- W2059946724 hasConcept C2777589648 @default.
- W2059946724 hasConcept C2777632594 @default.
- W2059946724 hasConcept C2777688143 @default.
- W2059946724 hasConcept C2778054964 @default.
- W2059946724 hasConcept C2778093475 @default.
- W2059946724 hasConcept C2779234561 @default.
- W2059946724 hasConcept C2780942790 @default.
- W2059946724 hasConcept C2781087480 @default.
- W2059946724 hasConcept C54355233 @default.
- W2059946724 hasConcept C71924100 @default.
- W2059946724 hasConcept C86803240 @default.
- W2059946724 hasConceptScore W2059946724C126322002 @default.
- W2059946724 hasConceptScore W2059946724C134018914 @default.