FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059959216> ?p ?o ?g. }

• W2059959216 abstract "Tributyltin (TBT) is known to cause developmental defects as endocrine disruptive chemicals (EDCs). At nanomoler concentrations, TBT actions were mediated by genomic pathways via PPAR/RXR. However, non-genomic target of TBT has not been elucidated. To investigate non-genomic TBT targets, we performed comprehensive metabolomic analyses using human embryonic carcinoma NT2/D1 cells. We found that 100 nM TBT reduced the amounts of α-ketoglutarate, succinate and malate. We further found that TBT decreased the activity of NAD-dependent isocitrate dehydrogenase (NAD-IDH), which catalyzes the conversion of isocitrate to α-ketoglutarate in the TCA cycle. In addition, TBT inhibited cell growth and enhanced neuronal differentiation through NAD-IDH inhibition. Furthermore, studies using bacterially expressed human NAD-IDH and in silico simulations suggest that TBT inhibits NAD-IDH due to a possible interaction. These results suggest that NAD-IDH is a novel non-genomic target of TBT at nanomolar levels. Thus, a metabolomic approach may provide new insights into the mechanism of EDC action." @default.
• W2059959216 created "2016-06-24" @default.
• W2059959216 creator A5019548450 @default.
• W2059959216 creator A5020653533 @default.
• W2059959216 creator A5026604772 @default.
• W2059959216 creator A5028592309 @default.
• W2059959216 creator A5081312271 @default.
• W2059959216 creator A5081462823 @default.
• W2059959216 date "2014-08-05" @default.
• W2059959216 modified "2023-09-30" @default.
• W2059959216 title "NAD-dependent isocitrate dehydrogenase as a novel target of tributyltin in human embryonic carcinoma cells" @default.
• W2059959216 cites W1597987623 @default.
• W2059959216 cites W1823994968 @default.
• W2059959216 cites W1965653791 @default.
• W2059959216 cites W1971420905 @default.
• W2059959216 cites W1972976212 @default.
• W2059959216 cites W1991185023 @default.
• W2059959216 cites W1996736495 @default.
• W2059959216 cites W1999156812 @default.
• W2059959216 cites W2001588476 @default.
• W2059959216 cites W2007793425 @default.
• W2059959216 cites W2010905056 @default.
• W2059959216 cites W2011120360 @default.
• W2059959216 cites W2017966908 @default.
• W2059959216 cites W2031890603 @default.
• W2059959216 cites W2042695020 @default.
• W2059959216 cites W2045426316 @default.
• W2059959216 cites W2051349454 @default.
• W2059959216 cites W2070667272 @default.
• W2059959216 cites W2071579644 @default.
• W2059959216 cites W2072278909 @default.
• W2059959216 cites W2078728909 @default.
• W2059959216 cites W2080335572 @default.
• W2059959216 cites W2081087228 @default.
• W2059959216 cites W2083437014 @default.
• W2059959216 cites W2084898686 @default.
• W2059959216 cites W2091897891 @default.
• W2059959216 cites W2101123856 @default.
• W2059959216 cites W2117611226 @default.
• W2059959216 cites W2123226237 @default.
• W2059959216 cites W2139883678 @default.
• W2059959216 cites W2149343603 @default.
• W2059959216 cites W2150008635 @default.
• W2059959216 cites W2151574084 @default.
• W2059959216 cites W2151723746 @default.
• W2059959216 cites W2157456005 @default.
• W2059959216 cites W2159071874 @default.
• W2059959216 doi "https://doi.org/10.1038/srep05952" @default.
• W2059959216 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4121607" @default.
• W2059959216 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25092173" @default.
• W2059959216 hasPublicationYear "2014" @default.
• W2059959216 type Work @default.
• W2059959216 sameAs 2059959216 @default.
• W2059959216 citedByCount "27" @default.
• W2059959216 countsByYear W20599592162015 @default.
• W2059959216 countsByYear W20599592162016 @default.
• W2059959216 countsByYear W20599592162017 @default.
• W2059959216 countsByYear W20599592162018 @default.
• W2059959216 countsByYear W20599592162019 @default.
• W2059959216 countsByYear W20599592162020 @default.
• W2059959216 countsByYear W20599592162021 @default.
• W2059959216 countsByYear W20599592162022 @default.
• W2059959216 countsByYear W20599592162023 @default.
• W2059959216 crossrefType "journal-article" @default.
• W2059959216 hasAuthorship W2059959216A5019548450 @default.
• W2059959216 hasAuthorship W2059959216A5020653533 @default.
• W2059959216 hasAuthorship W2059959216A5026604772 @default.
• W2059959216 hasAuthorship W2059959216A5028592309 @default.
• W2059959216 hasAuthorship W2059959216A5081312271 @default.
• W2059959216 hasAuthorship W2059959216A5081462823 @default.
• W2059959216 hasBestOaLocation W20599592161 @default.
• W2059959216 hasConcept C104317684 @default.
• W2059959216 hasConcept C127848430 @default.
• W2059959216 hasConcept C143065580 @default.
• W2059959216 hasConcept C145103041 @default.
• W2059959216 hasConcept C181199279 @default.
• W2059959216 hasConcept C185592680 @default.
• W2059959216 hasConcept C18903297 @default.
• W2059959216 hasConcept C21565614 @default.
• W2059959216 hasConcept C2776059313 @default.
• W2059959216 hasConcept C2777150147 @default.
• W2059959216 hasConcept C2779078112 @default.
• W2059959216 hasConcept C55493867 @default.
• W2059959216 hasConcept C60644358 @default.
• W2059959216 hasConcept C75520062 @default.
• W2059959216 hasConcept C86803240 @default.
• W2059959216 hasConcept C95444343 @default.
• W2059959216 hasConceptScore W2059959216C104317684 @default.
• W2059959216 hasConceptScore W2059959216C127848430 @default.
• W2059959216 hasConceptScore W2059959216C143065580 @default.
• W2059959216 hasConceptScore W2059959216C145103041 @default.
• W2059959216 hasConceptScore W2059959216C181199279 @default.
• W2059959216 hasConceptScore W2059959216C185592680 @default.
• W2059959216 hasConceptScore W2059959216C18903297 @default.
• W2059959216 hasConceptScore W2059959216C21565614 @default.
• W2059959216 hasConceptScore W2059959216C2776059313 @default.
• W2059959216 hasConceptScore W2059959216C2777150147 @default.
• W2059959216 hasConceptScore W2059959216C2779078112 @default.
• W2059959216 hasConceptScore W2059959216C55493867 @default.
• W2059959216 hasConceptScore W2059959216C60644358 @default.

• next