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- W2059968155 abstract "Abstract Aziridinocyclophosphazenes N3P3Az6 (code name MYKO 63), N4P4Az8 (code name MYKO 83) and relatives constituted the first generation of anticancer drugs whose efficiency on several rodent neoplasms was made conspicuous in a quantitative manner from 1976 to 1978 both in our Laboratory and by EORTC Screening Pharmacology Groups1. MYKO 63 appeared at that time as a promising drug for industrial development owing to its wide spectrum of activity and its very low mutagenicity2. However, this hope failed as a consequence of a cumulative toxicity which occurs upon heavy polyinjections schedules. In other words, MYKO 63 exhibits an uncomfortable kinetics of action on the tumor - and, consequently, of excretion - presumably due (it was our assumption) to a too high chemical stability of the molecule." @default.
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- W2059968155 date "1983-12-01" @default.
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- W2059968155 title "Cyclophosphazenes and Relatives as Anticancer Drugs" @default.
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- W2059968155 doi "https://doi.org/10.1080/03086648308076033" @default.
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