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• W2059969330 abstract "We report a noninvasive method for the monitoring of retinal ganglion cell (RGC) survival in live mice utilizing standard fluorescence microscopy.Transgenic mice expressing cyan fluorescent protein (CFP) under the regulation of an RGC-specific promoter Thy1 were used in this study.We established that Thy1-CFP expression is a quantitative reflection of the number of surviving RGCs, the fluorescence emission is stable for at least a year and that the loss of fluorescence correlates directly to glaucomatous damage. In high pressure glaucoma model, the peripheral retina is preferentially affected.Our live-imaging technique allows for the longitudinal assessment of RGC survival from the same animal. Noninvasive monitoring of neuronal cell death and survival is a powerful technique that would allow investigators to validate new potential glaucoma therapy based on neuroprotection." @default.
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• W2059969330 date "2009-11-24" @default.
• W2059969330 modified "2023-09-26" @default.
• W2059969330 title "Rapid and Noninvasive Imaging of Retinal Ganglion Cells in Live Mouse Models of Glaucoma" @default.
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• W2059969330 doi "https://doi.org/10.1007/s11307-009-0292-2" @default.
• W2059969330 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2889038" @default.
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