FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059969505> ?p ?o ?g. }

• W2059969505 endingPage "613" @default.
• W2059969505 startingPage "604" @default.
• W2059969505 abstract "In a number of pulmonary diseases, patients may develop abnormally viscous mucus reducing drug efficacy. To increase budesonide diffusion within lung fluid, we developed nanoporous microparticles (NPMPs) composed of budesonide and a mucokinetic, ambroxol hydrochloride, to be inhaled as a dry powder. Budesonide/ambroxol-HCl particles were formulated by spray drying and characterised by various physicochemicals methods. Aerodynamic properties were evaluated using a cascade impactor. Drugs apparent permeability coefficients were calculated across mucus producing Calu-3 cell monolayers cultivated at an air-liquid interface. Microparticles made only from budesonide and ambroxol-HCl had smooth surfaces. In the presence of ammonium carbonate ((NH4)2CO3), NPMPs were formulated, with significantly (P<0.05) superior aerodynamic properties (MMAD=1.87±0.22 μm and FPF=84.0±2.6%). The formation of nanopores and the increase in the specific surface area in the presence of (NH4)2CO3 were mainly attributed to the neutralisation of ambroxol-HCl to form ambroxol base. Thus, ambroxol base could behave in the same manner as budesonide and prompt nanoprecipitation when spray dried from an ethanol/water mix occurs. All formulations were amorphous, which should enhance dissolution rate and diffusion through lung fluid. These NPMPs were able to improve budesonide permeability across mucus producing Calu-3 cell monolayers (P<0.05) suggesting that they should be able to enhance budesonide diffusion in the lungs through viscous mucus." @default.
• W2059969505 created "2016-06-24" @default.
• W2059969505 creator A5001092385 @default.
• W2059969505 creator A5009691839 @default.
• W2059969505 creator A5042367583 @default.
• W2059969505 creator A5046196564 @default.
• W2059969505 creator A5046416793 @default.
• W2059969505 creator A5051080492 @default.
• W2059969505 creator A5073383878 @default.
• W2059969505 date "2013-11-01" @default.
• W2059969505 modified "2023-09-26" @default.
• W2059969505 title "Steroid/mucokinetic hybrid nanoporous microparticles for pulmonary drug delivery" @default.
• W2059969505 cites W1970240572 @default.
• W2059969505 cites W1972232063 @default.
• W2059969505 cites W1973482252 @default.
• W2059969505 cites W1975132504 @default.
• W2059969505 cites W1975872618 @default.
• W2059969505 cites W1978701589 @default.
• W2059969505 cites W1980803266 @default.
• W2059969505 cites W1987727624 @default.
• W2059969505 cites W1989877439 @default.
• W2059969505 cites W1991119065 @default.
• W2059969505 cites W2006371364 @default.
• W2059969505 cites W2011024089 @default.
• W2059969505 cites W2016475538 @default.
• W2059969505 cites W2016565975 @default.
• W2059969505 cites W2021439923 @default.
• W2059969505 cites W2024865483 @default.
• W2059969505 cites W2027114189 @default.
• W2059969505 cites W2032730185 @default.
• W2059969505 cites W2036399578 @default.
• W2059969505 cites W2044847259 @default.
• W2059969505 cites W2052198418 @default.
• W2059969505 cites W2054413050 @default.
• W2059969505 cites W2055117023 @default.
• W2059969505 cites W2071004669 @default.
• W2059969505 cites W2073119829 @default.
• W2059969505 cites W2077917016 @default.
• W2059969505 cites W2079551453 @default.
• W2059969505 cites W2080575627 @default.
• W2059969505 cites W2086713849 @default.
• W2059969505 cites W2101883647 @default.
• W2059969505 cites W2103497517 @default.
• W2059969505 cites W2105083509 @default.
• W2059969505 cites W2109066752 @default.
• W2059969505 cites W2109694473 @default.
• W2059969505 cites W2116478659 @default.
• W2059969505 cites W2123964352 @default.
• W2059969505 cites W2135314445 @default.
• W2059969505 cites W2136291881 @default.
• W2059969505 cites W2157692941 @default.
• W2059969505 cites W2169862673 @default.
• W2059969505 cites W2171955365 @default.
• W2059969505 cites W2329886131 @default.
• W2059969505 cites W2330380440 @default.
• W2059969505 doi "https://doi.org/10.1016/j.ejpb.2013.03.020" @default.
• W2059969505 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23563102" @default.
• W2059969505 hasPublicationYear "2013" @default.
• W2059969505 type Work @default.
• W2059969505 sameAs 2059969505 @default.
• W2059969505 citedByCount "27" @default.
• W2059969505 countsByYear W20599695052013 @default.
• W2059969505 countsByYear W20599695052014 @default.
• W2059969505 countsByYear W20599695052015 @default.
• W2059969505 countsByYear W20599695052016 @default.
• W2059969505 countsByYear W20599695052017 @default.
• W2059969505 countsByYear W20599695052018 @default.
• W2059969505 countsByYear W20599695052019 @default.
• W2059969505 countsByYear W20599695052020 @default.
• W2059969505 countsByYear W20599695052021 @default.
• W2059969505 countsByYear W20599695052022 @default.
• W2059969505 countsByYear W20599695052023 @default.
• W2059969505 crossrefType "journal-article" @default.
• W2059969505 hasAuthorship W2059969505A5001092385 @default.
• W2059969505 hasAuthorship W2059969505A5009691839 @default.
• W2059969505 hasAuthorship W2059969505A5042367583 @default.
• W2059969505 hasAuthorship W2059969505A5046196564 @default.
• W2059969505 hasAuthorship W2059969505A5046416793 @default.
• W2059969505 hasAuthorship W2059969505A5051080492 @default.
• W2059969505 hasAuthorship W2059969505A5073383878 @default.
• W2059969505 hasBestOaLocation W20599695052 @default.
• W2059969505 hasConcept C126322002 @default.
• W2059969505 hasConcept C185592680 @default.
• W2059969505 hasConcept C18903297 @default.
• W2059969505 hasConcept C2776136866 @default.
• W2059969505 hasConcept C2776330663 @default.
• W2059969505 hasConcept C2776804153 @default.
• W2059969505 hasConcept C2777312293 @default.
• W2059969505 hasConcept C42219234 @default.
• W2059969505 hasConcept C43617362 @default.
• W2059969505 hasConcept C55493867 @default.
• W2059969505 hasConcept C58226133 @default.
• W2059969505 hasConcept C71924100 @default.
• W2059969505 hasConcept C86803240 @default.
• W2059969505 hasConcept C98274493 @default.
• W2059969505 hasConceptScore W2059969505C126322002 @default.
• W2059969505 hasConceptScore W2059969505C185592680 @default.
• W2059969505 hasConceptScore W2059969505C18903297 @default.

• next