Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059969553> ?p ?o ?g. }
- W2059969553 endingPage "390" @default.
- W2059969553 startingPage "390" @default.
- W2059969553 abstract "Liver synthesizes thrombopoietin, which is a major cytokine involved in the production of hematopoietic cells. The purpose of this study was to examine the effects of preferential liver irradiation on expression of thrombopoietin and production of hematopoietic cells. About 70% of the liver of C57BL6/J mice was irradiated with 20 Gy of gamma rays. Exposure to ionizing radiation enhanced hematopoietic progenitors and megakaryocyte frequency in bone marrow and induced a transient increase in platelet and neutrophil counts that peaked 14 days after irradiation. The concentration of thrombopoietin was increased in serum as early as 5 h after liver irradiation and was still elevated at day 14. By using Northern blot analysis and an RNase protection assay, we showed that thrombopoietin mRNA was increased in the irradiated liver. To determine whether thrombopoietin was involved in the stimulation of hematopoiesis, we irradiated mice in which thrombopoietin deficiency had been induced by homologous recombination. Platelet levels were increased in both heterozygous and homozygous thrombopoietin-deficient mice with a magnitude similar to that obtained in normal mice. In summary, our data demonstrate that local irradiation of the abdomen encompassing the liver leads to stimulation of hematopoiesis through a thrombopoietin-independent mechanism." @default.
- W2059969553 created "2016-06-24" @default.
- W2059969553 creator A5012616713 @default.
- W2059969553 creator A5016239385 @default.
- W2059969553 creator A5021283021 @default.
- W2059969553 creator A5031095099 @default.
- W2059969553 creator A5031789027 @default.
- W2059969553 date "1999-10-01" @default.
- W2059969553 modified "2023-10-02" @default.
- W2059969553 title "Preferential Liver Irradiation Enhances Hematopoiesis through a Thrombopoietin-Independent Mechanism" @default.
- W2059969553 cites W1488152543 @default.
- W2059969553 cites W1591067068 @default.
- W2059969553 cites W1693659057 @default.
- W2059969553 cites W173282636 @default.
- W2059969553 cites W1863874903 @default.
- W2059969553 cites W1890881866 @default.
- W2059969553 cites W190052799 @default.
- W2059969553 cites W1940414069 @default.
- W2059969553 cites W1966928413 @default.
- W2059969553 cites W1975341205 @default.
- W2059969553 cites W1983612778 @default.
- W2059969553 cites W198401084 @default.
- W2059969553 cites W1991439587 @default.
- W2059969553 cites W1991537949 @default.
- W2059969553 cites W1998004541 @default.
- W2059969553 cites W2018678473 @default.
- W2059969553 cites W2033154561 @default.
- W2059969553 cites W2037899459 @default.
- W2059969553 cites W2038818733 @default.
- W2059969553 cites W2051098801 @default.
- W2059969553 cites W2065577646 @default.
- W2059969553 cites W2068395389 @default.
- W2059969553 cites W2089468267 @default.
- W2059969553 cites W2093409235 @default.
- W2059969553 cites W2093758335 @default.
- W2059969553 cites W2094618962 @default.
- W2059969553 cites W2125665207 @default.
- W2059969553 cites W2131595503 @default.
- W2059969553 cites W2134812217 @default.
- W2059969553 cites W2145139769 @default.
- W2059969553 cites W2202298688 @default.
- W2059969553 cites W2207343046 @default.
- W2059969553 cites W2260183312 @default.
- W2059969553 cites W2262312629 @default.
- W2059969553 cites W2287680939 @default.
- W2059969553 cites W2316318798 @default.
- W2059969553 cites W2403174101 @default.
- W2059969553 cites W2405225359 @default.
- W2059969553 cites W2409448564 @default.
- W2059969553 cites W2413771008 @default.
- W2059969553 cites W2414471267 @default.
- W2059969553 cites W2417688184 @default.
- W2059969553 cites W303701243 @default.
- W2059969553 doi "https://doi.org/10.2307/3580223" @default.
- W2059969553 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10477915" @default.
- W2059969553 hasPublicationYear "1999" @default.
- W2059969553 type Work @default.
- W2059969553 sameAs 2059969553 @default.
- W2059969553 citedByCount "7" @default.
- W2059969553 countsByYear W20599695532014 @default.
- W2059969553 countsByYear W20599695532015 @default.
- W2059969553 countsByYear W20599695532016 @default.
- W2059969553 countsByYear W20599695532022 @default.
- W2059969553 crossrefType "journal-article" @default.
- W2059969553 hasAuthorship W2059969553A5012616713 @default.
- W2059969553 hasAuthorship W2059969553A5016239385 @default.
- W2059969553 hasAuthorship W2059969553A5021283021 @default.
- W2059969553 hasAuthorship W2059969553A5031095099 @default.
- W2059969553 hasAuthorship W2059969553A5031789027 @default.
- W2059969553 hasConcept C109159458 @default.
- W2059969553 hasConcept C126322002 @default.
- W2059969553 hasConcept C134018914 @default.
- W2059969553 hasConcept C203014093 @default.
- W2059969553 hasConcept C2776958478 @default.
- W2059969553 hasConcept C2777863708 @default.
- W2059969553 hasConcept C2778690821 @default.
- W2059969553 hasConcept C2779705218 @default.
- W2059969553 hasConcept C2780007613 @default.
- W2059969553 hasConcept C28328180 @default.
- W2059969553 hasConcept C71924100 @default.
- W2059969553 hasConcept C86803240 @default.
- W2059969553 hasConcept C95444343 @default.
- W2059969553 hasConceptScore W2059969553C109159458 @default.
- W2059969553 hasConceptScore W2059969553C126322002 @default.
- W2059969553 hasConceptScore W2059969553C134018914 @default.
- W2059969553 hasConceptScore W2059969553C203014093 @default.
- W2059969553 hasConceptScore W2059969553C2776958478 @default.
- W2059969553 hasConceptScore W2059969553C2777863708 @default.
- W2059969553 hasConceptScore W2059969553C2778690821 @default.
- W2059969553 hasConceptScore W2059969553C2779705218 @default.
- W2059969553 hasConceptScore W2059969553C2780007613 @default.
- W2059969553 hasConceptScore W2059969553C28328180 @default.
- W2059969553 hasConceptScore W2059969553C71924100 @default.
- W2059969553 hasConceptScore W2059969553C86803240 @default.
- W2059969553 hasConceptScore W2059969553C95444343 @default.
- W2059969553 hasIssue "4" @default.
- W2059969553 hasLocation W20599695531 @default.
- W2059969553 hasLocation W20599695532 @default.