FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059977896> ?p ?o ?g. }

• W2059977896 endingPage "658" @default.
• W2059977896 startingPage "643" @default.
• W2059977896 abstract "1. We studied the effect of platelet activating factor (PAF) on leakage of albumin, and secretion of fucose (a marker for mucus glycoprotein) and protein into the tracheal lumen of the guinea-pig isolated in situ, and on bioelectric properties and fluxes of mannitol in vitro. We also studied the effect of PAF on mucus secretion in human bronchi in vitro. 2. In guinea-pig, intravenous PAF markedly increased the luminal concentration of protein but did not significantly increase fucose concentrations. Increased albumin leakage (274% above controls at a dose of 50 ng/kg PAF) was associated with the increased luminal content of protein (248% above controls at the same dose of PAF). 3. Leakage of albumin was maximal 10 min after PAF, was significantly reduced by 20 min and had returned to baseline by 30 min. This pattern of leakage could be repeated with successive administrations of PAF. 4. PAF induced small but significant biphasic changes in bioelectric properties in vitro. The initial response was rapid in onset and characterized by maximal increases in short-circuit current (Isc) of 6.5% above controls at 7.5 min and in conductance (G) of 7% at 20 min. Both responses were blocked by the PAF receptor antagonist WEB 2086. Amiloride blocked the increase in Isc. Permeability of the tissue to mannitol (Pmann) was unaltered. The delayed response was characterized by maximal increases in Isc and G of 10% above controls at 60-90 min which were not significantly affected by WEB 2086 or amiloride. Pmann was increased by 38% at 90 min. 5. PAF increased fucose secretion in human bronchi in vitro. 6. Lyso-PAF in vitro caused changes similar to those induced by PAF on bioelectric properties and mucus secretion, but had no significant effects in vivo. 7. Light microscopy showed no evidence of epithelial disruption in animals given intravenous PAF at a dose causing significant albumin transudation. 8. We conclude that PAF increases the protein content of guinea-pig tracheal fluid principally by inducing plasma leakage rather than mucus secretion and that the small changes in ion transport and epithelial conductance may reduce the tendency to epithelial disruption during plasma leakage." @default.
• W2059977896 created "2016-06-24" @default.
• W2059977896 creator A5005714301 @default.
• W2059977896 creator A5030258071 @default.
• W2059977896 creator A5032519084 @default.
• W2059977896 creator A5042411586 @default.
• W2059977896 creator A5062776492 @default.
• W2059977896 creator A5084029368 @default.
• W2059977896 date "1990-12-01" @default.
• W2059977896 modified "2023-09-27" @default.
• W2059977896 title "Effect of platelet activating factor on formation and composition of airway fluid in the guinea-pig trachea." @default.
• W2059977896 cites W1682738682 @default.
• W2059977896 cites W1775749144 @default.
• W2059977896 cites W1869326453 @default.
• W2059977896 cites W1926802803 @default.
• W2059977896 cites W1967408591 @default.
• W2059977896 cites W1984664788 @default.
• W2059977896 cites W1999341159 @default.
• W2059977896 cites W2011378798 @default.
• W2059977896 cites W2025801887 @default.
• W2059977896 cites W2039348243 @default.
• W2059977896 cites W2043333805 @default.
• W2059977896 cites W205437916 @default.
• W2059977896 cites W2056630497 @default.
• W2059977896 cites W2071936009 @default.
• W2059977896 cites W2095122286 @default.
• W2059977896 cites W2096866316 @default.
• W2059977896 cites W2107119536 @default.
• W2059977896 cites W2141710896 @default.
• W2059977896 cites W2255413633 @default.
• W2059977896 cites W2344841257 @default.
• W2059977896 cites W2344868937 @default.
• W2059977896 cites W2395243521 @default.
• W2059977896 cites W2402426079 @default.
• W2059977896 cites W240943799 @default.
• W2059977896 cites W2409673282 @default.
• W2059977896 cites W2410222271 @default.
• W2059977896 cites W2442526331 @default.
• W2059977896 cites W4299127648 @default.
• W2059977896 doi "https://doi.org/10.1113/jphysiol.1990.sp018352" @default.
• W2059977896 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1181796" @default.
• W2059977896 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1712848" @default.
• W2059977896 hasPublicationYear "1990" @default.
• W2059977896 type Work @default.
• W2059977896 sameAs 2059977896 @default.
• W2059977896 citedByCount "24" @default.
• W2059977896 countsByYear W20599778962019 @default.
• W2059977896 countsByYear W20599778962020 @default.
• W2059977896 countsByYear W20599778962021 @default.
• W2059977896 countsByYear W20599778962022 @default.
• W2059977896 crossrefType "journal-article" @default.
• W2059977896 hasAuthorship W2059977896A5005714301 @default.
• W2059977896 hasAuthorship W2059977896A5030258071 @default.
• W2059977896 hasAuthorship W2059977896A5032519084 @default.
• W2059977896 hasAuthorship W2059977896A5042411586 @default.
• W2059977896 hasAuthorship W2059977896A5062776492 @default.
• W2059977896 hasAuthorship W2059977896A5084029368 @default.
• W2059977896 hasBestOaLocation W20599778962 @default.
• W2059977896 hasConcept C126322002 @default.
• W2059977896 hasConcept C134018914 @default.
• W2059977896 hasConcept C178790620 @default.
• W2059977896 hasConcept C185592680 @default.
• W2059977896 hasConcept C202751555 @default.
• W2059977896 hasConcept C2776125364 @default.
• W2059977896 hasConcept C2778445172 @default.
• W2059977896 hasConcept C2778815084 @default.
• W2059977896 hasConcept C2779020240 @default.
• W2059977896 hasConcept C2779608910 @default.
• W2059977896 hasConcept C537181965 @default.
• W2059977896 hasConcept C55493867 @default.
• W2059977896 hasConcept C71924100 @default.
• W2059977896 hasConcept C86803240 @default.
• W2059977896 hasConcept C86807702 @default.
• W2059977896 hasConceptScore W2059977896C126322002 @default.
• W2059977896 hasConceptScore W2059977896C134018914 @default.
• W2059977896 hasConceptScore W2059977896C178790620 @default.
• W2059977896 hasConceptScore W2059977896C185592680 @default.
• W2059977896 hasConceptScore W2059977896C202751555 @default.
• W2059977896 hasConceptScore W2059977896C2776125364 @default.
• W2059977896 hasConceptScore W2059977896C2778445172 @default.
• W2059977896 hasConceptScore W2059977896C2778815084 @default.
• W2059977896 hasConceptScore W2059977896C2779020240 @default.
• W2059977896 hasConceptScore W2059977896C2779608910 @default.
• W2059977896 hasConceptScore W2059977896C537181965 @default.
• W2059977896 hasConceptScore W2059977896C55493867 @default.
• W2059977896 hasConceptScore W2059977896C71924100 @default.
• W2059977896 hasConceptScore W2059977896C86803240 @default.
• W2059977896 hasConceptScore W2059977896C86807702 @default.
• W2059977896 hasIssue "1" @default.
• W2059977896 hasLocation W20599778961 @default.
• W2059977896 hasLocation W20599778962 @default.
• W2059977896 hasLocation W20599778963 @default.
• W2059977896 hasOpenAccess W2059977896 @default.
• W2059977896 hasPrimaryLocation W20599778961 @default.
• W2059977896 hasRelatedWork W1486873552 @default.
• W2059977896 hasRelatedWork W1966504330 @default.
• W2059977896 hasRelatedWork W1979139803 @default.
• W2059977896 hasRelatedWork W1998188673 @default.

• next