FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059989672> ?p ?o ?g. }

• W2059989672 endingPage "6343" @default.
• W2059989672 startingPage "6334" @default.
• W2059989672 abstract "Parallel visual pathways are initiated at the first retinal synapse by signaling between the rod and cone photoreceptors and two general classes of bipolar cells. For normal function, ON or depolarizing bipolar cells (DBCs) require the G-protein-coupled receptor, mGluR6, an intact G-protein-coupled cascade and the transient receptor potential melastatin 1 (TRPM1) cation channel. In addition, another seven transmembrane protein, GPR179, is required for DBC function and recruits the regulators of G-protein signaling (RGS) proteins, RGS7 and RGS11, to the dendritic tips of the DBCs. Here we use the Gpr179 nob5 mouse, which lacks GPR179 and has a no b-wave electroretinogram (ERG) phenotype, to demonstrate that despite the absence of both GPR179 and RGS7/RGS11, a small dark-adapted ERG b-wave remains and can be enhanced with long duration flashes. Consistent with the ERG, the mGluR6-mediated gating of TRPM1 can be evoked pharmacologically in Gpr179 nob5 and RGS7 −/− / RGS11 −/− rod BCs if strong stimulation conditions are used. In contrast, direct gating of TRPM1 by capsaicin in RGS7 −/− / RGS11 −/− and WT rod BCs is similar, but severely compromised in Gpr179 nob5 rod BCs. Noise and standing current analyses indicate that the remaining channels in Gpr179 nob5 and RGS7 −/− / RGS11 −/− rod BCs have a very low open probability. We propose that GPR179 along with RGS7 and RGS11 controls the ability of the mGluR6 cascade to gate TRPM1. In addition to its role in localizing RGS7 and RGS11 to the dendritic tips, GPR179 via a direct interaction with the TRPM1 channel alters its ability to be gated directly by capsaicin." @default.
• W2059989672 created "2016-06-24" @default.
• W2059989672 creator A5012897767 @default.
• W2059989672 creator A5021495934 @default.
• W2059989672 creator A5024900490 @default.
• W2059989672 creator A5033322796 @default.
• W2059989672 creator A5035702853 @default.
• W2059989672 creator A5047985485 @default.
• W2059989672 creator A5061375714 @default.
• W2059989672 creator A5080693295 @default.
• W2059989672 creator A5084345116 @default.
• W2059989672 date "2014-04-30" @default.
• W2059989672 modified "2023-10-16" @default.
• W2059989672 title "GPR179 Is Required for High Sensitivity of the mGluR6 Signaling Cascade in Depolarizing Bipolar Cells" @default.
• W2059989672 cites W1538222550 @default.
• W2059989672 cites W1591131155 @default.
• W2059989672 cites W1995457345 @default.
• W2059989672 cites W1997374942 @default.
• W2059989672 cites W2008774823 @default.
• W2059989672 cites W2013037594 @default.
• W2059989672 cites W2013636393 @default.
• W2059989672 cites W2021296813 @default.
• W2059989672 cites W2026018650 @default.
• W2059989672 cites W2028876091 @default.
• W2059989672 cites W2029564703 @default.
• W2059989672 cites W2030209163 @default.
• W2059989672 cites W2034262791 @default.
• W2059989672 cites W2036801340 @default.
• W2059989672 cites W2040778024 @default.
• W2059989672 cites W2040960622 @default.
• W2059989672 cites W2045779425 @default.
• W2059989672 cites W2048997930 @default.
• W2059989672 cites W2056038780 @default.
• W2059989672 cites W2057243830 @default.
• W2059989672 cites W2057270842 @default.
• W2059989672 cites W2059033870 @default.
• W2059989672 cites W2061629295 @default.
• W2059989672 cites W2074414519 @default.
• W2059989672 cites W2074419912 @default.
• W2059989672 cites W2076706751 @default.
• W2059989672 cites W2081614214 @default.
• W2059989672 cites W2094910328 @default.
• W2059989672 cites W2111669702 @default.
• W2059989672 cites W2116783999 @default.
• W2059989672 cites W2125536218 @default.
• W2059989672 cites W2134500883 @default.
• W2059989672 cites W2138865114 @default.
• W2059989672 cites W2139672209 @default.
• W2059989672 cites W2157469754 @default.
• W2059989672 cites W2161274454 @default.
• W2059989672 cites W2162642543 @default.
• W2059989672 cites W2416924514 @default.
• W2059989672 doi "https://doi.org/10.1523/jneurosci.4044-13.2014" @default.
• W2059989672 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4004817" @default.
• W2059989672 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24790204" @default.
• W2059989672 hasPublicationYear "2014" @default.
• W2059989672 type Work @default.
• W2059989672 sameAs 2059989672 @default.
• W2059989672 citedByCount "55" @default.
• W2059989672 countsByYear W20599896722014 @default.
• W2059989672 countsByYear W20599896722015 @default.
• W2059989672 countsByYear W20599896722016 @default.
• W2059989672 countsByYear W20599896722017 @default.
• W2059989672 countsByYear W20599896722018 @default.
• W2059989672 countsByYear W20599896722019 @default.
• W2059989672 countsByYear W20599896722020 @default.
• W2059989672 countsByYear W20599896722021 @default.
• W2059989672 countsByYear W20599896722022 @default.
• W2059989672 countsByYear W20599896722023 @default.
• W2059989672 crossrefType "journal-article" @default.
• W2059989672 hasAuthorship W2059989672A5012897767 @default.
• W2059989672 hasAuthorship W2059989672A5021495934 @default.
• W2059989672 hasAuthorship W2059989672A5024900490 @default.
• W2059989672 hasAuthorship W2059989672A5033322796 @default.
• W2059989672 hasAuthorship W2059989672A5035702853 @default.
• W2059989672 hasAuthorship W2059989672A5047985485 @default.
• W2059989672 hasAuthorship W2059989672A5061375714 @default.
• W2059989672 hasAuthorship W2059989672A5080693295 @default.
• W2059989672 hasAuthorship W2059989672A5084345116 @default.
• W2059989672 hasBestOaLocation W20599896721 @default.
• W2059989672 hasConcept C169760540 @default.
• W2059989672 hasConcept C170493617 @default.
• W2059989672 hasConcept C185592680 @default.
• W2059989672 hasConcept C194544171 @default.
• W2059989672 hasConcept C26702167 @default.
• W2059989672 hasConcept C55493867 @default.
• W2059989672 hasConcept C56940625 @default.
• W2059989672 hasConcept C61174792 @default.
• W2059989672 hasConcept C86803240 @default.
• W2059989672 hasConcept C95444343 @default.
• W2059989672 hasConceptScore W2059989672C169760540 @default.
• W2059989672 hasConceptScore W2059989672C170493617 @default.
• W2059989672 hasConceptScore W2059989672C185592680 @default.
• W2059989672 hasConceptScore W2059989672C194544171 @default.
• W2059989672 hasConceptScore W2059989672C26702167 @default.
• W2059989672 hasConceptScore W2059989672C55493867 @default.
• W2059989672 hasConceptScore W2059989672C56940625 @default.
• W2059989672 hasConceptScore W2059989672C61174792 @default.

• next