FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059995495> ?p ?o ?g. }

• W2059995495 endingPage "208" @default.
• W2059995495 startingPage "203" @default.
• W2059995495 abstract "Brain-derived neurotrophic factor (BDNF), a member of the neurotrophins, has been reported to ameliorate hyperglycemia in obese diabetic animal models. To elucidate the mechanism of BDNF on glucose metabolism, we determined the glucose turnover under basal and euglycemic hyperinsulinemic (insulin infusion rate, 54 pmol. kg(-1). min(-1)) clamp conditions in obese insulin-resistant rats, male Zucker fatty rats, which had been acutely administered a subcutaneous injection of BDNF (20 mg/kg) (n = 9, BDNF) or vehicle (n = 8, vehicle). Under the basal condition, acute administration of BDNF did not affect the blood glucose level, plasma insulin level, rate of glucose disappearance (Rd), and endogenous glucose production (EGP). Under the clamp condition, the glucose infusion rate (GIR) was significantly higher in BDNF than in vehicle (mean +/- SD, 61.4 +/- 19.1 v 41.4 +/- 4.9 micromol. kg(-1). min(-1), P <.05). There was no significant difference in Rd and EGP between the 2 groups under the clamp condition, but the insulin-mediated suppression ratio of endogenous glucose production in BDNF was significantly greater than in vehicle (48.9 +/- 22.2 v 22.4% +/- 20.6%, P <.05). In BDNF, mRNA expressions of hepatic phosphoenolpyruvate carboxykinase (PEPCK) and glucose-6-phosphatase (G6Pase) were comparable to those of vehicle, while hepatic glucokinase (GK) mRNA expression was significantly higher (1.57 +/- 0.33 v 1.03 +/- 0.17, P <.05). We conclude that BDNF mainly improves hepatic insulin resistance in obese insulin-resistant rats, probably by affecting the hepatic GK flux." @default.
• W2059995495 created "2016-06-24" @default.
• W2059995495 creator A5005067593 @default.
• W2059995495 creator A5015718204 @default.
• W2059995495 creator A5022981263 @default.
• W2059995495 creator A5025316186 @default.
• W2059995495 creator A5028043877 @default.
• W2059995495 creator A5029154836 @default.
• W2059995495 creator A5036582307 @default.
• W2059995495 creator A5046968982 @default.
• W2059995495 creator A5053306211 @default.
• W2059995495 creator A5056345700 @default.
• W2059995495 creator A5064081508 @default.
• W2059995495 creator A5075733456 @default.
• W2059995495 creator A5084247658 @default.
• W2059995495 creator A5090362877 @default.
• W2059995495 date "2003-02-01" @default.
• W2059995495 modified "2023-09-30" @default.
• W2059995495 title "Brain-derived neurotrophic factor ameliorates hepatic insulin resistance in Zucker fatty rats" @default.
• W2059995495 cites W1676164379 @default.
• W2059995495 cites W1979722180 @default.
• W2059995495 cites W1986673931 @default.
• W2059995495 cites W2006227380 @default.
• W2059995495 cites W2009660050 @default.
• W2059995495 cites W2015911535 @default.
• W2059995495 cites W2016761017 @default.
• W2059995495 cites W2017924085 @default.
• W2059995495 cites W2019864299 @default.
• W2059995495 cites W2028713882 @default.
• W2059995495 cites W2029378794 @default.
• W2059995495 cites W2033125833 @default.
• W2059995495 cites W2041981567 @default.
• W2059995495 cites W2043877459 @default.
• W2059995495 cites W2062074929 @default.
• W2059995495 cites W2090785610 @default.
• W2059995495 cites W2104295145 @default.
• W2059995495 cites W2105610005 @default.
• W2059995495 cites W2128537656 @default.
• W2059995495 cites W2133151521 @default.
• W2059995495 cites W2135027079 @default.
• W2059995495 cites W2159031404 @default.
• W2059995495 cites W2160961970 @default.
• W2059995495 cites W2163978606 @default.
• W2059995495 cites W2196957880 @default.
• W2059995495 doi "https://doi.org/10.1053/meta.2003.50026" @default.
• W2059995495 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12601633" @default.
• W2059995495 hasPublicationYear "2003" @default.
• W2059995495 type Work @default.
• W2059995495 sameAs 2059995495 @default.
• W2059995495 citedByCount "34" @default.
• W2059995495 countsByYear W20599954952012 @default.
• W2059995495 countsByYear W20599954952014 @default.
• W2059995495 countsByYear W20599954952015 @default.
• W2059995495 countsByYear W20599954952016 @default.
• W2059995495 countsByYear W20599954952017 @default.
• W2059995495 countsByYear W20599954952018 @default.
• W2059995495 countsByYear W20599954952020 @default.
• W2059995495 countsByYear W20599954952021 @default.
• W2059995495 countsByYear W20599954952022 @default.
• W2059995495 countsByYear W20599954952023 @default.
• W2059995495 crossrefType "journal-article" @default.
• W2059995495 hasAuthorship W2059995495A5005067593 @default.
• W2059995495 hasAuthorship W2059995495A5015718204 @default.
• W2059995495 hasAuthorship W2059995495A5022981263 @default.
• W2059995495 hasAuthorship W2059995495A5025316186 @default.
• W2059995495 hasAuthorship W2059995495A5028043877 @default.
• W2059995495 hasAuthorship W2059995495A5029154836 @default.
• W2059995495 hasAuthorship W2059995495A5036582307 @default.
• W2059995495 hasAuthorship W2059995495A5046968982 @default.
• W2059995495 hasAuthorship W2059995495A5053306211 @default.
• W2059995495 hasAuthorship W2059995495A5056345700 @default.
• W2059995495 hasAuthorship W2059995495A5064081508 @default.
• W2059995495 hasAuthorship W2059995495A5075733456 @default.
• W2059995495 hasAuthorship W2059995495A5084247658 @default.
• W2059995495 hasAuthorship W2059995495A5090362877 @default.
• W2059995495 hasConcept C126322002 @default.
• W2059995495 hasConcept C134018914 @default.
• W2059995495 hasConcept C160539049 @default.
• W2059995495 hasConcept C170493617 @default.
• W2059995495 hasConcept C17093226 @default.
• W2059995495 hasConcept C185592680 @default.
• W2059995495 hasConcept C2777391703 @default.
• W2059995495 hasConcept C2778024521 @default.
• W2059995495 hasConcept C2778790584 @default.
• W2059995495 hasConcept C2779306644 @default.
• W2059995495 hasConcept C71924100 @default.
• W2059995495 hasConcept C98335778 @default.
• W2059995495 hasConceptScore W2059995495C126322002 @default.
• W2059995495 hasConceptScore W2059995495C134018914 @default.
• W2059995495 hasConceptScore W2059995495C160539049 @default.
• W2059995495 hasConceptScore W2059995495C170493617 @default.
• W2059995495 hasConceptScore W2059995495C17093226 @default.
• W2059995495 hasConceptScore W2059995495C185592680 @default.
• W2059995495 hasConceptScore W2059995495C2777391703 @default.
• W2059995495 hasConceptScore W2059995495C2778024521 @default.
• W2059995495 hasConceptScore W2059995495C2778790584 @default.
• W2059995495 hasConceptScore W2059995495C2779306644 @default.
• W2059995495 hasConceptScore W2059995495C71924100 @default.

• next