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- W2060018808 abstract "Amino acid sequences of peptides are often inferred from their amino acid compositions by comparison with homologous peptides of known sequence. The probabilities are considered that by such an approach errors are made due to the occurrence of balanced double changes, i.e. reciprocal substitutions, between two homologous peptides of identical compositions. Formulae are derived for the calculation of these probabilities, depending on peptide length and evolutionary distance. However, such calculations requiring too much computer time, the probabilities for reciprocal substitutions are estimated by simulation of evolutionary changes in peptides. It can be concluded from the resulting data that for many purposes the possible errors in amino acid sequences partially inferred from amino acid compositions are acceptably small." @default.
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- W2060018808 date "1978-08-01" @default.
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- W2060018808 title "Reciprocal amino acid substitutions in the evolution of homologous peptides" @default.
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- W2060018808 doi "https://doi.org/10.1016/0022-5193(78)90158-3" @default.
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